Person
Langenau, David
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Biography and Research Interest
Our laboratory uses transgenic zebrafish models of rabdomyosarcoma to uncover the mechanisms by which a subset of malignant cells, the cancer stem cell, can remake tumor.
Using fluorescent transgenic zebrafish and cutting-edge live cell imaging, we are now visualizing ERMS development in real-time. Moreover, our fluorescent transgenic approaches allow for the identification of malignant cell sub-types and should afford unprecedented opportunities to visualize self-renewal within a tumor directly. Using conditional transgenic approaches and chemical genetics, we are currently interrogating which pathways modulate self-renewal, cancer stem cell number, and tumor growth in ERMS. Uncovering downstream molecular pathways that regulate self-renewal will be integral to identifying novel drugs for the treatment of this disease.
Using fluorescent transgenic zebrafish and cutting-edge live cell imaging, we are now visualizing ERMS development in real-time. Moreover, our fluorescent transgenic approaches allow for the identification of malignant cell sub-types and should afford unprecedented opportunities to visualize self-renewal within a tumor directly. Using conditional transgenic approaches and chemical genetics, we are currently interrogating which pathways modulate self-renewal, cancer stem cell number, and tumor growth in ERMS. Uncovering downstream molecular pathways that regulate self-renewal will be integral to identifying novel drugs for the treatment of this disease.
Non-Zebrafish Publications