PUBLICATION
Novel steroidogenic factor-1 homolog (ff1d) is coexpressed with anti-Mullerian hormone (AMH) in zebrafish
- Authors
- von Hofsten, J., Larsson, A., and Olsson, P.E.
- ID
- ZDB-PUB-050318-15
- Date
- 2005
- Source
- Developmental Dynamics : an official publication of the American Association of Anatomists 233(2): 595-604 (Journal)
- Registered Authors
- Larsson, Tomas A., von Hofsten, Jonas
- Keywords
- ff1d, NR5A, FTZ-F1, AMH, MIS, sex determination
- MeSH Terms
-
- Amino Acid Sequence
- Animals
- Anti-Mullerian Hormone
- DNA-Binding Proteins/chemistry
- DNA-Binding Proteins/genetics
- DNA-Binding Proteins/metabolism*
- Embryo, Nonmammalian/embryology
- Embryo, Nonmammalian/metabolism
- Female
- Gene Expression Regulation, Developmental*
- Glycoproteins/genetics
- Glycoproteins/metabolism*
- Homeodomain Proteins
- Humans
- Male
- Molecular Sequence Data
- Ovary/metabolism
- Phylogeny
- Receptors, Cytoplasmic and Nuclear
- Sequence Alignment
- Steroidogenic Factor 1
- Testicular Hormones/genetics
- Testicular Hormones/metabolism*
- Testis/metabolism
- Transcription Factors/chemistry
- Transcription Factors/genetics
- Transcription Factors/metabolism*
- Zebrafish/embryology*
- Zebrafish/genetics
- Zebrafish/growth & development
- Zebrafish/metabolism*
- Zebrafish Proteins/chemistry
- Zebrafish Proteins/genetics
- Zebrafish Proteins/metabolism*
- PubMed
- 15768398 Full text @ Dev. Dyn.
Citation
von Hofsten, J., Larsson, A., and Olsson, P.E. (2005) Novel steroidogenic factor-1 homolog (ff1d) is coexpressed with anti-Mullerian hormone (AMH) in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 233(2):595-604.
Abstract
ff1d is a novel zebrafish FTZ-F1 gene with sequence characteristics indicating similar basic regulatory mechanisms as the previously characterized ff1 based on the presence of an FTZ-F1 box in the DNA binding domain and an interactive domain (I-Box) and an AF-2 in the ligand binding domain. The highest sequence similarity was found between ff1d and ff1b (NR5A4), a gene previously shown to be a functional homolog to the steroidogenic factor 1 (SF-1). The expression pattern of ff1d was comparable to ff1b both in brain and gonads in adults and in the pituitary and interrenal cells in embryos. SF-1 is crucial in mammalian steroidogenesis and in sex determination by regulating the anti-Mullerian hormone (AMH). In fish, AMH has not been described previously. In this study, we cloned a partial zebrafish AMH. AMH was detected in growing oocytes, the ovarian follicular layer and testicular Sertoli cells, similar to the mammalian pattern, suggesting a conserved role between zebrafish and mammalian AMH. Teleosts lack a gene homolog to SRY, which constitute the universal testis-determining factor in mammalian sex determination. Comparison of sequences and expression patterns indicate that ff1d is a new candidate for sex determination and differentiation in a way similar to SF-1, possibly involving AMH. Developmental Dynamics, 2005. (c) 2005 Wiley-Liss, Inc.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping