PUBLICATION
Zebrafish Dpr2 inhibits mesoderm induction by promoting degradation of nodal receptors
- Authors
- Zhang, L., Zhou, H., Su, Y., Sun, Z., Zhang, H., Zhang, L., Zhang, Y., Ning, Y., Chen, Y.G., and Meng, A.
- ID
- ZDB-PUB-041006-8
- Date
- 2004
- Source
- Science (New York, N.Y.) 306(5693): 114-117 (Journal)
- Registered Authors
- Meng, Anming, Sun, Zhihui, Su, Ying, Zhang, Haiwen, Zhang, Lixia
- Keywords
- none
- MeSH Terms
-
- Lysosomes/metabolism
- Protein Serine-Threonine Kinases
- Endosomes/metabolism
- Zebrafish/embryology*
- Zebrafish/genetics
- Zebrafish/metabolism
- Animals
- Signal Transduction
- Activin Receptors, Type I/metabolism*
- Fluorescent Antibody Technique
- Mesoderm/physiology*
- Amino Acid Sequence
- Embryo, Nonmammalian/embryology
- Embryo, Nonmammalian/metabolism*
- Oligonucleotides, Antisense
- Humans
- Gene Expression Profiling
- Proteins/metabolism
- Zebrafish Proteins/chemistry
- Zebrafish Proteins/genetics
- Zebrafish Proteins/metabolism*
- Transforming Growth Factor beta/genetics
- Transforming Growth Factor beta/metabolism
- Gene Expression Regulation, Developmental
- Molecular Sequence Data
- Mutation
- Embryonic Induction*
- Nodal Signaling Ligands
- In Situ Hybridization
- Intracellular Signaling Peptides and Proteins
- Cell Line
- Receptors, Transforming Growth Factor beta/metabolism*
- PubMed
- 15459392 Full text @ Science
Citation
Zhang, L., Zhou, H., Su, Y., Sun, Z., Zhang, H., Zhang, L., Zhang, Y., Ning, Y., Chen, Y.G., and Meng, A. (2004) Zebrafish Dpr2 inhibits mesoderm induction by promoting degradation of nodal receptors. Science (New York, N.Y.). 306(5693):114-117.
Abstract
Nodal proteins, members of the transforming growth factor-beta (TGFbeta) superfamily, have been identified as key endogenous mesoderm inducers in vertebrates. Precise control of Nodal signaling is essential for normal development of embryos. Here, we report that zebrafish dapper2 (dpr2) is expressed in mesoderm precursors during early embryogenesis and is positively regulated by Nodal signals. In vivo functional studies in zebrafish suggest that Dpr2 suppresses mesoderm induction activities of Nodal signaling. Dpr2 is localized in late endosomes, binds to the TGFbeta receptors ALK5 and ALK4, and accelerates lysosomal degradation of these receptors.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping