ZFIN Person: Meng, Anming

ZFIN ID: ZDB-PERS-000331-1

ZFIN ID: ZDB-PERS-000331-1

Meng, Anming

Email:	mengam@mail.tsinghua.edu.cn
URL:
Affiliation:	Meng Lab
Address:	Laboratory of Devlopmental Biology School of Life Sciences Tsinghua University Qinghuayuan, Haidian District Beijing , 100084 China
Country:	China
Phone:	86-10-62782256 (O), 86-10-62782257 (L)
Fax:	86-10-62794401
ORCID ID:

BIOGRAPHY AND RESEARCH INTERESTS

My lab is particularly interested in the roles of Nodal, FGF and Wnt signaling pathways in mesoderm induction and dorsovental patterning of the zebrafish embryo. We are also identifying maternal factors and aim to understand their functions in early embryonic development.

PUBLICATIONS

Shen, W., Gong, B., Xing, C., Zhang, L., Sun, J., Chen, Y., Yang, C., Yan, L., Chen, L., Yao, L., Li, G., Deng, H., Wu, X., Meng, A. (2022) Comprehensive maturity of nuclear pore complexes regulates zygotic genome activation. Cell. 185(26):4954-4970.e20

Xing, C., Shen, W., Gong, B., Li, Y., Yan, L., Meng, A. (2022) Maternal Factors and Nodal Autoregulation Orchestrate Nodal Gene Expression for Embryonic Mesendoderm Induction in the Zebrafish. Frontiers in cell and developmental biology. 10:887987

Wu, X., Zhang, H., Zhang, B., Zhang, Y., Wang, Q., Shen, W., Wu, X., Li, L., Xia, W., Nakamura, R., Liu, B., Liu, F., Takeda, H., Meng, A., Xie, W. (2021) Methylome inheritance and enhancer dememorization reset an epigenetic gate safeguarding embryonic programs. Science advances. 7:eabl3858

Chen, L., Xu, W., Liu, K., Jiang, Z., Han, Y., Jin, H., Zhang, L., Shen, W., Jia, S., Sun, Q., Meng, A. (2021) 5' Half of specific tRNAs feeds back to promote corresponding tRNA gene transcription in vertebrate embryos. Science advances. 7:eabh0494

Gong, B., Guo, Y., Ding, S., Liu, X., Meng, A., Li, D., Jia, S. (2021) A Golgi-derived vesicle potentiates PtdIns4P to PtdIns3P conversion for endosome fission. Nature cell biology. 23:782-795

Zhang, L., Chen, L., Chen, J., Shen, W., Meng, A. (2020) Mini-III RNase-based dual-color system for in vivo mRNA tracking. Development (Cambridge, England). 147(22):

He, X., Chen, W., Liu, Z., Yu, G., Chen, Y., Cai, Y.J., Sun, L., Xu, W., Zhong, L., Gao, C., Chen, J., Zhang, M., Yang, S., Yao, Y., Zhang, Z., Ma, F., Zhang, C.C., Lu, H.P., Yu, B., Cheng, T.L., Qiu, J., Sheng, Q., Zhou, H.M., Lv, Z.R., Yan, J., Zhou, Y., Qiu, Z., Cui, Z., Zhang, X., Meng, A., Sun, Q., Yang, Y. (2020) Efficient and risk-reduced genome editing using double nicks enhanced by bacterial recombination factors in multiple species. Nucleic acids research. 48(10):e57

Jiang, D., Jiang, Z., Lu, D., Wang, X., Liang, H., Zhang, J., Meng, Y., Li, Y., Wu, D., Huang, Y., Chen, Y., Deng, H., Wu, Q., Xiong, J., Meng, A., Yu, L. (2019) Migrasomes provide regional cues for organ morphogenesis during zebrafish gastrulation. Nature cell biology. 21:966-977

Yang, Y., Wang, L., Han, X., Yang, W.L., Zhang, M., Ma, H.L., Sun, B.F., Li, A., Xia, J., Chen, J., Heng, J., Wu, B., Chen, Y.S., Xu, J.W., Yang, X., Yao, H., Sun, J., Lyu, C., Wang, H.L., Huang, Y., Sun, Y.P., Zhao, Y.L., Meng, A., Ma, J., Liu, F., Yang, Y.G. (2019) RNA 5-Methylcytosine Facilitates the Maternal-to-Zygotic Transition by Preventing Maternal mRNA Decay. Molecular Cell. 75(6):1188-1202.e11

Gong, B., Li, Z., Xiao, W., Li, G., Ding, S., Meng, A., Jia, S. (2019) Sec14l3 potentiates VEGFR2 signaling to regulate zebrafish vasculogenesis. Nature communications. 10:1606

Yan, L., Chen, J., Zhu, X., Sun, J., Wu, X., Shen, W., Zhang, W., Tao, Q., Meng, A. (2018) Maternal Huluwa dictates the embryonic body axis through β-catenin in vertebrates. Science (New York, N.Y.). 362(6417)

Zhang, B., Wu, X., Zhang, W., Shen, W., Sun, Q., Liu, K., Zhang, Y., Wang, Q., Li, Y., Meng, A., Xie, W. (2018) Widespread Enhancer Dememorization and Promoter Priming during Parental-to-Zygotic Transition. Molecular Cell. 72:673-686.e6

Sun, J., Yan, L., Shen, W., Meng, A. (2018) Maternal Ybx1 safeguards zebrafish oocyte maturation and maternal-to-zygotic transition by repressing global translation. Development (Cambridge, England). 145(19):

Wang, Y., Han, Y., Xu, P., Ding, S., Li, G., Jin, H., Meng, Y., Meng, A., Jia, S. (2018) prpf4 is essential for cell survival and posterior lateral line primordium migration in zebrafish. Journal of genetics and genomics = Yi chuan xue bao. 45(8):443-453

Wu, X., Shen, W., Zhang, B., Meng, A. (2018) The genetic program of oocytes can be modified in vivo in the zebrafish ovary. Journal of molecular cell biology. 10(6):479-493

Yao, L., Chen, J., Wu, X., Jia, S., Meng, A. (2017) Zebrafish cdc6 hypomorphic mutation causes Meier-Gorlin syndrome-like phenotype. Human molecular genetics. 26(21):4168-4180

Stainier, D.Y.R., Raz, E., Lawson, N.D., Ekker, S.C., Burdine, R.D., Eisen, J.S., Ingham, P.W., Schulte-Merker, S., Yelon, D., Weinstein, B.M., Mullins, M.C., Wilson, S.W., Ramakrishnan, L., Amacher, S.L., Neuhauss, S.C.F., Meng, A., Mochizuki, N., Panula, P., Moens, C.B. (2017) Guidelines for morpholino use in zebrafish. PLoS Genetics. 13:e1007000

Zhang, Y., Xue, Y., Cao, C., Huang, J., Hong, Q., Hai, T., Jia, Q., Wang, X., Qin, G., Yao, J., Wang, X., Zheng, Q., Zhang, R., Li, Y., Luo, A., Zhang, N., Shi, G., Wang, Y., Ying, H., Liu, Z., Wang, H., Meng, A., Zhou, Q., Wei, H., Liu, F., Zhao, J. (2017) Thyroid hormone regulates hematopoiesis via the TR-KLF9 axis. Blood. 130(20):2161-2170

Sun, Q., Liu, X., Gong, B., Wu, D., Meng, A., Jia, S. (2017) Alkbh4 and Atrn Act Maternally to Regulate Zebrafish Epiboly. International journal of biological sciences. 13:1051-1066

Hai, T., Cao, C., Shang, H., Guo, W., Mu, Y., Yang, S., Zhang, Y., Zheng, Q., Zhang, T., Wang, X., Liu, Y., Kong, Q., Li, K., Wang, D., Qi, M., Hong, Q., Zhang, R., Wang, X., Jia, Q., Wang, X., Qin, G., Li, Y., Luo, A., Jin, W., Yao, J., Huang, J., Zhang, H., Li, M., Xie, X., Zheng, X., Guo, K., Wang, Q., Zhang, S., Li, L., Xie, F., Zhang, Y., Weng, X., Yin, Z., Hu, K., Cong, Y., Zheng, P., Zou, H., Xin, L., Xia, J., Ruan, J., Li, H., Zhao, W., Yuan, J., Liu, Z., Gu, W., Li, M., Wang, Y., Wang, H., Yang, S., Liu, Z., Wei, H., Zhao, J., Zhou, Q., Meng, A. (2017) A pilot study of large-scale production of mutant pigs by ENU mutagenesis. eLIFE. 6

Gao, Q., Zhang, J., Wang, X., Liu, Y., He, R., Liu, X., Wang, F., Feng, J., Yang, D., Wang, Z., Meng, A., Yan, X. (2017) The signalling receptor MCAM coordinates apical-basal polarity and planar cell polarity during morphogenesis. Nature communications. 8:15279

Gong, B., Shen, W., Xiao, W., Meng, Y., Meng, A., Jia, S. (2017) The Sec14-like phosphatidylinositol transfer proteins Sec14l3/SEC14L2 act as GTPase proteins to mediate Wnt/Ca²⁺ signaling.. eLIFE. 6

Chen, J., Wu, X., Yao, L., Yan, L., Zhang, L., Qiu, J., Liu, X., Jia, S., Meng, A. (2017) Impairment of Cargo Transportation Caused by gbf1 Mutation Disrupts Vascular Integrity and Causes Hemorrhage in Zebrafish Embryos.. The Journal of biological chemistry. 292(6):2315-2327

Ma, D., Xue, Y., Zhang, Y., Sun, Y., Meng, A., Liu, F. (2016) The rising zebrafish research in China: Meeting report of the 3rd Chinese Zebrafish Principal Investigator Meeting & the Inaugural Meeting of China Zebrafish Society. Journal of genetics and genomics = Yi chuan xue bao. 43(10):617-620

Zhang, B., Zheng, H., Huang, B., Li, W., Xiang, Y., Peng, X., Ming, J., Wu, X., Zhang, Y., Xu, Q., Liu, W., Kou, X., Zhao, Y., He, W., Li, C., Chen, B., Li, Y., Wang, Q., Ma, J., Yin, Q., Kee, K., Meng, A., Gao, S., Xu, F., Na, J., Xie, W. (2016) Allelic reprogramming of the histone modification H3K4me3 in early mammalian development. Nature. 537:553-557

Liu, Z., Ning, G., Xu, R., Cao, Y., Meng, A., Wang, Q. (2016) Fscn1 is required for the trafficking of TGF-β family type I receptors during endoderm formation. Nature communications. 7:12603

Qiu, J., Fan, X., Wang, Y., Jin, H., Song, Y., Han, Y., Huang, S., Meng, Y., Tang, F., Meng, A. (2016) Embryonic hematopoiesis in vertebrate somites gives rise to definitive hematopoietic stem cells. Journal of molecular cell biology. 8(4):288-301

Zhang, J.F., Jiang, Z., Liu, X., Meng, A. (2016) Eph-ephrin signaling maintains the boundary of dorsal forerunner cell cluster during morphogenesis of the zebrafish embryonic left-right organizer. Development (Cambridge, England). 143(14):2603-15

Yang, Z., Zhong, H., Chen, J., Zhang, X., Zhang, H., Luo, X., Xu, S., Chen, H., Lu, D., Han, Y., Li, J., Fu, L., Qi, X., Peng, Y., Xiang, K., Lin, Q., Guo, Y., Li, M., Cao, X., Zhang, Y., Liao, S., Peng, Y., Zhang, L., Guo, X., Dong, S., Liang, F., Wang, J., Willden, A., Aun, H.S., Serey, B., Sovannary, T., Bunnath, L., Samnom, H., Mardon, G., Li, Q., Meng, A., Shi, H., Su, B. (2016) A genetic mechanism for convergent skin lightening during recent human evolution. Molecular Biology and Evolution. 33(5):1177-87

Liu, X., Wang, Q., Meng, A. (2016) Detection of Smad Signaling in Zebrafish Embryos. Methods in molecular biology (Clifton, N.J.). 1344:275-286

Xue, Y., Xing, C., Zhang, W., Chen, C., Xu, J., Meng, A., Pan, Y. (2016) Coordinate involvement of Nodal-dependent inhibition and Wnt-dependent activation in the maintenance of organizer-specific bmp2b in zebrafish. The International journal of developmental biology. 60(1-2-3):13-19

Xiong, C., Liu, X., Meng, A. (2015) The Kinase Activity-deficient Isoform of the Protein Araf Antagonizes Ras/Mitogen-activated Protein Kinase (Ras/MAPK) Signaling in the Zebrafish Embryo. The Journal of biological chemistry. 290(42):25512-21

Ma, Y., Liu, X., Liu, Z., Wei, S., Shang, H., Xue, Y., Cao, Y., Meng, A., Wang, Q. (2015) The Chromatin Remodeling Protein Bptf Promotes Posterior Neuroectodermal Fate by Enhancing Smad2-Activated wnt8a Expression. The Journal of neuroscience : the official journal of the Society for Neuroscience. 35:8493-506

Xing, C., Gong, B., Xue, Y., Han, Y., Wang, Y., Meng, A., Jia, S. (2015) TGFβ1a regulates zebrafish posterior lateral line formation via Smad5 mediated pathway. Journal of molecular cell biology. 7(1):48-61

Han, X., Gui, B., Xiong, C., Zhao, L., Liang, J., Sun, L., Yang, X., Yu, W., Si, W., Yan, R., Yi, X., Zhang, D., Li, W., Li, L., Yang, J., Wang, Y., Sun, Y.E., Zhang, D., Meng, A., Shang, Y. (2014) Destabilizing LSD1 by Jade-2 promotes neurogenesis: an antibraking system in neural development. Molecular Cell. 55:482-94

Xu, P., Zhu, G., Wang, Y., Sun, J., Liu, X., Chen, Y.G., Meng, A. (2014) Maternal Eomesodermin regulates zygotic nodal gene expression for mesendoderm induction in zebrafish embryos. Journal of molecular cell biology. 6(4):272-85

Wu, D., Chen, L., Sun, Q., Wu, X., Jia, S., Meng, A. (2014) Uracil-DNA Glycosylase is involved in DNA demethylation and required for embryonic development in the zebrafish embryo. The Journal of biological chemistry. 289(22):15463-15473

Xue, Y., Zheng, X., Huang, L., Xu, P., Ma, Y., Min, Z., Tao, Q., Tao, Y., Meng, A. (2014) Organizer-derived Bmp2 is required for the formation of a correct Bmp activity gradient during embryonic development. Nature communications. 5:3766

Niu, X., Hong, J., Zheng, X., Melville, D.B., Knapik, E.W., Meng, A., Peng, J. (2014) The Nuclear Pore Complex Function of Sec13 Protein Is Required for Cell Survival during Retinal Development. The Journal of biological chemistry. 289:11971-85

Ning, G., Liu, X., Dai, M., Meng, A., and Wang, Q. (2013) MicroRNA-92a upholds Bmp signaling by targeting noggin3 during pharyngeal cartilage formation. Developmental Cell. 24(3):283-295

Liu, X., Xiong, C., Jia, S., Zhang, Y., Chen, Y.G., Wang, Q., and Meng, A. (2013) Araf kinase antagonizes Nodal-Smad2 activity in mesendoderm development by directly phosphorylating the Smad2 linker region. Nature communications. 4:1728

Zheng, X., Yang, S., Han, Y., Zhao, X., Zhao, L., Tian, T., Tong, J., Xu, P., Xiong, C., and Meng, A. (2012) Loss of zygotic NUP107 protein causes missing of pharyngeal skeleton and other tissue defects with impaired nuclear pore function in zebrafish embryos. The Journal of biological chemistry. 287(45):38254-38264

Peng, J., Zhang, J., and Meng, A. (2012) The tiny zebrafish keep swimming fast in the developmental biology pond. Journal of genetics and genomics = Yi chuan xue bao. 39(9):419-420

Liu, X., Ning, G., Meng, A., and Wang, Q. (2012) MicroRNA-206 regulates cell movements during zebrafish gastrulation by targeting prickle1a and regulating JNK2 phosphorylation. Molecular and cellular biology. 32(14):2934-2942

Zhang, M., Zhang, J., Lin, S.C., and Meng, A. (2012) beta-Catenin 1 and beta-catenin 2 play similar and distinct roles in left-right asymmetric development of zebrafish embryos. Development (Cambridge, England). 139(11):2009-2019

Jia, S., Dai, F., Wu, D., Lin, X., Xing, C., Xue, Y., Wang, Y., Xiao, M., Wu, W., Feng, X.H., and Meng, A. (2012) Protein Phosphatase 4 Cooperates with Smads to Promote BMP Signaling in Dorsoventral Patterning of Zebrafish Embryos. Developmental Cell. 22(5):1065-1078

Li, Z., Wang, Y., Zhang, M., Xu, P., Huang, H., Wu, D., and Meng, A. (2012) Amotl2 gene inhibits Wnt/beta-catenin signaling and regulates embryonic development in zebrafish embryoys. The Journal of biological chemistry. 287(16):13005-13015

Dworkin, S., Darido, C., Georgy, S.R., Wilanowski, T., Srivastava, S., Ellett, F., Pase, L., Han, Y., Meng, A., Heath, J.K., Lieschke, G.J., and Jane, S.M. (2012) Midbrain-hindbrain boundary patterning and morphogenesis are regulated by diverse grainy head-like 2-dependent pathways. Development (Cambridge, England). 139(3):525-536

Wang, Y., Li, Z., Xu, P., Huang, L., Tong, J., Huang, H., and Meng, A. (2011) Angiomotin-like2 Gene (amotl2) Is Required for Migration and Proliferation of Endothelial Cells during Angiogenesis. The Journal of biological chemistry. 286(47):41095-104

Han, Y., Mu, Y., Li, X., Xu, P., Tong, J., Liu, Z., Ma, T., Zeng, G., Yang, S., Du, J., and Meng, A. (2011) Grhl2 deficiency impairs otic development and hearing ability in a zebrafish model of the progressive dominant hearing loss DFNA28. Human molecular genetics. 20(16):3213-26

Liu, Z., Lin, X., Cai, Z., Zhang, Z., Han, C., Jia, S., Meng, A., and Wang, Q. (2011) Global identification of SMAD2 target genes reveals a role for multiple co-regulatory factors in zebrafish early gastrulas. The Journal of biological chemistry. 286(32):28520-32

Cui, Y., He, S., Xing, C., Lu, K., Wang, J., Xing, G., Meng, A., Jia, S., He, F., and Zhang, L. (2011) SCF(FBXL15) regulates BMP signalling by directing the degradation of HECT‐type ubiquitin ligase Smurf1. The EMBO journal. 30(13):2675-89

Xia, L., Jia, S., Huang, S., Wang, H., Zhu, Y., Mu, Y., Kan, L., Zheng, W., Wu, D., Li, X., Sun, Q., Meng, A., and Chen, D. (2010) The Fused/Smurf Complex Controls the Fate of Drosophila Germline Stem Cells by Generating a Gradient BMP Response. Cell. 143(6):978-990

Zhao, X., Zhao, L., Tian, T., Zhang, Y., Tong, J., Zheng, X., and Meng, A. (2010) Interruption of cenph causes mitotic failure and embryonic death and its haploinsufficiency suppresses cancer in zebrafish. The Journal of biological chemistry. 285(36):27924-27934

Li, X., Jia, S., Wang, S., Wang, Y., and Meng, A. (2009) Mta3-NuRD complex is a master regulator for initiation of primitive hematopoiesis in vertebrate embryos. Blood. 114(27):5464-5472

Tian, T., Zhao, L., Zhao, X., Zhang, M., and Meng, A. (2009) A zebrafish gene trap line expresses GFP recapturing expression pattern of foxj1b. Journal of genetics and genomics = Yi chuan xue bao. 36(10):581-589

Jia, S., Wu, D., Xing, C., and Meng, A. (2009) Smad2/3 activities are required for induction and patterning of the neuroectoderm in zebrafish. Developmental Biology. 333(2):273-284

Zhang, Y., Li, X., Qi, J., Wang, J., Liu, X., Zhang, H., Lin, S.C., and Meng, A. (2009) Rock2 controls TGFβ signaling and inhibits mesoderm induction in zebrafish embryos. Journal of Cell Science. 122(Pt 13):2197-2207

Tian, T., Zhao, L., Zhang, M., Zhao, X., and Meng, A. (2009) Both foxj1a and foxj1b are implicated in left-right asymmetric development in zebrafish embryos. Biochemical and Biophysical Research Communications. 380(3):537-542

Gao, X., Wen, J., Zhang, L., Li, X., Ning, Y., Meng, A., and Chen, Y.G. (2008) Dapper1 is a nucleocytoplasmic shuttling protein that negatively modulates Wnt signaling in the nucleus. The Journal of biological chemistry. 283(51):35679-35688

Zhao, L., Zhao, X., Tian, T., Lu, Q., Skrbo-Larssen, N., Wu, D., Kuang, Z., Zheng, X., Han, Y., Yang, S., Zhang, C., and Meng, A. (2008) Heart-specific isoform of tropomyosin4 is essential for heartbeat in zebrafish embryos. Cardiovascular research. 80(2):200-208

Lu, Z., Liu, W., Huang, H., He, Y., Han, Y., Wang, Y., Li, Q., Ruan, K., Ye, Z., Low, B.C., Meng, A., and Lin, S.C. (2008) Protein encoded by the AxinFu allele effectively downregulates Wnt signaling but exerts a dominant negative effect on c-Jun N-terminal kinase signaling. The Journal of biological chemistry. 283(19):13132-13139

Jia, S., Ren, Z., Li, X., Zheng, Y., and Meng, A. (2008) smad2 and smad3 Are Required for Mesendoderm Induction by Transforming Growth Factor-β/Nodal Signals in Zebrafish. The Journal of biological chemistry. 283(4):2418-2426

Rui, Y., Xu, Z., Xiong, B., Cao, Y., Lin, S., Zhang, M., Chan, S.C., Luo, W., Han, Y., Lu, Z., Ye, Z., Zhou, H.M., Han, J., Meng, A., and Lin, S.C. (2007) A beta-Catenin-Independent Dorsalization Pathway Activated by Axin/JNK Signaling and Antagonized by Aida. Developmental Cell. 13(2):268-282

Zhang, S., Fei, T., Zhang, L., Zhang, R., Chen, F., Ning, Y., Han, Y., Feng, X.H., Meng, A., and Chen, Y.G. (2007) Smad7 antagonizes TGF-{beta} signaling in the nucleus by interfering with functional Smad-DNA complex formation. Molecular and cellular biology. 27(12):4488-4499

Ma, A.C., Lin, R., Chan, P.K., Leung, J.C., Chan, L.Y., Meng, A., Verfaillie, C.M., Liang, R., and Leung, A.Y. (2007) The role of survivin in angiogenesis during zebrafish embryonic development. BMC Developmental Biology. 7(1):50

Jia, S., and Meng, A. (2007) Tob genes in development and homeostasis. Developmental Dynamics : an official publication of the American Association of Anatomists. 236(4):913-921

Su, Y., Zhang, L., Gao, X., Meng, F., Wen, J., Zhou, H., Meng, A., and Chen, Y.G. (2007) The evolutionally conserved activity of Dapper2 in antagonizing TGF-beta signaling. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 21(3):682-690

Huang, H., Lu, F.I., Jia, S., Meng, S., Cao, Y., Wang, Y., Ma, W., Yin, K., Wen, Z., Peng, J., Thisse, C., Thisse, B., and Meng, A. (2007) Amotl2 is essential for cell movements in zebrafish embryo and regulates c-Src translocation. Development (Cambridge, England). 134(5):979-988

Sun, Z., Zhao, J., Zhang, Y., and Meng, A. (2006) Sp5l is a mediator of Fgf signals in anteroposterior patterning of the neuroectoderm in zebrafish embryo. Developmental Dynamics : an official publication of the American Association of Anatomists. 235(11):2999-3006

Xiong, B., Rui, Y., Zhang, M., Shi, K., Jia, S., Tian, T., Yin, K., Huang, H., Lin, S., Zhao, X., Chen, Y., Chen, Y.G., Lin, S.C., and Meng, A. (2006) Tob1 controls dorsal development of zebrafish embryos by antagonizing maternal beta-catenin transcriptional activity. Developmental Cell. 11(2):225-238

Sun, Z., Jin, P., Tian, T., Gu, Y., Chen, Y.G., and Meng, A. (2006) Activation and roles of ALK4/ALK7-mediated maternal TGFbeta signals in zebrafish embryo. Biochemical and Biophysical Research Communications. 345(2):694-703

Lin, X., Duan, X., Liang, Y.Y., Su, Y., Wrighton, K.H., Long, J., Hu, M., Davis, C.M., Wang, J., Brunicardi, F.C., Shi, Y., Chen, Y.G., Meng, A., and Feng, X.H. (2006) PPM1A functions as a Smad phosphatase to terminate TGFbeta signaling. Cell. 125(5):915-928

Zhao, C., He, X., Tian, C., and Meng, A. (2006) Two GC-rich boxes in huC promoter play distinct roles in controlling its neuronal specific expression in zebrafish embryos. Biochemical and Biophysical Research Communications. 342(1):214-220

Gu, Y., Jin, P., Zhang, L., Zhao, X., Gao, X., Ning, Y., Meng, A., and Chen, Y.G. (2006) Functional analysis of mutations in the kinase domain of the TGF-β receptor ALK1 reveals different mechanisms for induction of hereditary hemorrhagic telangiectasia. Blood. 107(5):1951-1954

Cheung, C.Y., Webb, S.E., Meng, A., and Miller, A.L. (2006) Transient expression of apoaequorin in zebrafish embryos: extending the ability to image calcium transients during later stages of development. The International journal of developmental biology. 50(6):561-569

Zhao, C., Qi, J., and Meng, A. (2005) Characterization and expression pattern of two zebrafish atf7 genes. Developmental Dynamics : an official publication of the American Association of Anatomists. 233(3):1157-1162

Zhao, C., and Meng, A. (2005) Sp1-like transcription factors are regulators of embryonic development in vertebrates. Development, growth & differentiation. 47(4):2001-211

Penberthy, W.T., Zhao, C., Zhang, Y., Jessen, J.R., Yang, Z., Bricaud, O., Collazo, A., Meng, A., and Lin, S. (2004) Pur alpha and Sp8 as opposing regulators of neural gata2 expression. Developmental Biology. 275(1):225-234

Jin, P., Tian, T., Sun, Z. H., and Meng, A. M. (2004) Generation of mutants with developmental defects in zebrafish by ENU mutagenesis. Chinese science bulletin = Kexue tongbao. 49(20):2154-2158

Zhang, L., Zhou, H., Su, Y., Sun, Z., Zhang, H., Zhang, L., Zhang, Y., Ning, Y., Chen, Y.G., and Meng, A. (2004) Zebrafish Dpr2 inhibits mesoderm induction by promoting degradation of nodal receptors. Science (New York, N.Y.). 306(5693):114-117

Cao, Y., Zhao, J., Sun, Z., Zhao, Z., Postlethwait, J., and Meng, A. (2004) fgf17b, a novel member of Fgf family, helps patterning zebrafish embryos. Developmental Biology. 271(1):130-143

Shi, K., Zhang, L., and Meng, A. (2004) Cloning and expression analysis of zebrafish tob1 gene. Development genes and evolution. 214(6):309-311

Teng, P., Cao, Y., Wang, W.X., Zhu, S.X., Meng, A.M., and Zhang, J.P. (2004) The shh promoter of zebrafish directs the expression of GFP in notochord. Yi chuan xue bao = Acta genetica Sinica. 31(1):39-42

Zhao, J., Cao, Y., Zhao, C., Postlethwait, J., and Meng, A. (2003) An SP1-like transcription factor Spr2 acts downstream of Fgf signaling to mediate mesoderm induction. The EMBO journal. 22(22):6078-6088

Cao, Y., Zhao, J., Wang, Y., and Meng, A. (2003) Expression of zebrafish Lc3 synthase gene in embryonic lens requires hedgehog signaling. Developmental Dynamics : an official publication of the American Association of Anatomists. 228(3):308-312

Zhao, C.-T., Shi, K.-H., Su, Y., Liang, L.-Y., Yan, Y.-L, Postlethwait, J., and Meng, A.-M. (2003) Two variants of zebrafish p100 are expressed during embryogenesis and regulated by Nodal signaling. FEBS letters. 543(1-3):190-195

Li, M., Su, Y., and Meng, A.M. (2002) Induction of cranial and posterior trunk neural crest by exogenous retinoic acid in zebrafish. Chinese science bulletin = Kexue tongbao. 47(13):1105-1108

Sun, Z., Shi, K., Su, Y., and Meng, A. (2002) A novel zinc finger transcription factor resembles krox-20 in structure and in expression pattern in zebrafish. Mechanisms of Development. 114(1-2):133

Li, M., Zhao, C., Wang, Y., Zhao, Z., and Meng, A. (2002) Zebrafish sox9b is an early neural crest marker. Development genes and evolution. 212(4):203-206

Su, Y. and Meng, A. (2002) The expression of gbx-2 during zebrafish embryogenesis. Mechanisms of Development. 113(1):107-110

Zhao, C.T., Zhang, Y., Su, Y., and Meng, A.M. (2002) Somite-specific expression of a novel fibronectin variant FN3 is negatively regulated by SHH. Chinese science bulletin = Kexue tongbao. 47(21):1807-1811

Liang, L.Y., Li, M., Wang, Y., Zhao, C.T., Zhao, Z.X., and Meng, A.M. (2001) The zygotic expression of zebrafish trebf during embryogenesis is restricted to the embryonic shield and its derivatives. Development genes and evolution. 211(8-9):445-448

Zhang, L., Hua, Z., Ren, J., and Meng, A. (2001) The nuclear localization signal of zebrafish terra is located within the DM domain. FEBS letters. 503(1):25-29

Li, M., Cao, Y., Zhao, Z.X., Lin, S., and Meng, A.M. (2001) Characterization and expression pattern of pouII1, a novel class II POU gene in zebrafish. Chinese science bulletin = Kexue tongbao. 46(18):1523-1527

Zhao, Z.X., Cao, Y., Li, M., and Meng, A.M. (2001) Double-stranded RNA injection produces nonspecific defects in zebrafish. Developmental Biology. 229(1):215-223

Meng, A. and Lin, S. (2000) Tissue-specific expression of GFP reporter gene in germline driven by GATA-2 promoter and enhancers in zebrafish. Chinese science bulletin = Kexue tongbao. 45(1):31-34

Meng, A., Moore, B., Tang, H., Yuan, B., and Lin, S. (1999) A Drosophila doublesex-related gene, terra, is involved in somitogenesis in vertebrates. Development (Cambridge, England). 126:1259-1268

Meng, A., Tang, H., Yuan, B.Z., Ong, B.A., Long, Q.M., and Lin, S. (1999) Positive and Negative Cis-Acting Elements Are Required for Hematopoietic Expression of Zebrafish GATA-1. Blood. 93(2):500-508

Meng, A., Jessen, J.R., and Lin, S. (1999) Transgenesis. In The Zebrafish: Genetics and Genomics, H.W. Detrich, III, M. Westerfield, and L.I. Zon, eds., San Diego, CA: Academic Press, Methods Cell Biol.. 60:133-148

Jessen, J.R., Meng, A., McFarlane, R.J., Paw, B.H., Zon, L.I., Smith, G.R., and Lin, S. (1998) Modification of bacterial artificial chromosomes through Chi-stimulated homologous recombination and its application in zebrafish transgenesis. Proceedings of the National Academy of Sciences of the United States of America. 95:5121-5126

Long, Q.M., Meng, A.M., Wang, H., Jessen, J.R., Farrell, M.J., and Lin, S. (1997) GATA-1 expression pattern can be recapitulated in living transgenic zebrafish using GFP reporter gene. Development (Cambridge, England). 124(20):4105-4111

Meng, A., Tang, H., Ong, B.A., Farrell, M.J., and Lin, S. (1997) Promoter analysis in living zebrafish embryos identifies a cis-acting motif required for neuronal expression of GATA-2. Proceedings of the National Academy of Sciences of the United States of America. 94(12):6267-6272

NON-ZEBRAFISH PUBLICATIONS
Meng, F.W., Cheng, X., Yang, L.L., Hou, N., Yang, X., Meng, A.M. (2008) Accelerated re-epithelialization in Dpr2-deficient mice is associated with enhanced response to TGF-b signaling. Journal of Cell Science, 121:2904-2912.

Tian, T., and Meng, A. M. (2006) Nodal signals pattern vertebrate embryos. Cell. Mol. Life. Sci., 63(6):672-685

Zhao, C. T., and Meng, A. M. (2005) Sp1-like transcription factors are regulators of embryonic development in vertebrates. Dev. Growth Diff., 47(4):201-211

Chen, Y. G., and Meng, A. M. (2004) Negative regulation of TGF-beta signaling in development. Cell Res., 14(6):441-449