PUBLICATION
Heparan sulfate core proteins in cell-cell signaling
- Authors
- Kramer, K.L. and Yost, H.J.
- ID
- ZDB-PUB-031119-7
- Date
- 2003
- Source
- Annual review of genetics 37: 461-484 (Review)
- Registered Authors
- Kramer, Kenneth, Yost, H. Joseph
- Keywords
- none
- MeSH Terms
-
- Animals
- Cell Communication/physiology*
- Golgi Apparatus/physiology
- Heparan Sulfate Proteoglycans/physiology*
- Mice
- Xenopus
- PubMed
- 14616070 Full text @ Annu. Rev. Genet.
Citation
Kramer, K.L. and Yost, H.J. (2003) Heparan sulfate core proteins in cell-cell signaling. Annual review of genetics. 37:461-484.
Abstract
Heparan sulfate (HS) binds numerous extracellular ligands, including cell-cell signaling molecules and their signal-transducing receptors. Ligand binding sites in HS have specific sulfation patterns; and several observations suggest that the HS sulfation pattern is the same for every HS chain that a cell synthesizes, regardless of the core protein to which it is attached. Nonetheless, virtually every Drosophila, zebrafish, Xenopus, and mouse that lacks a specific HS core protein has a mutant phenotype, even though other HS core proteins are expressed in the affected cells. Genetic manipulation of HS core protein genes is beginning to indicate that HS core proteins have functional specificities that are required during distinct stages of development.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping