ZFIN ID: ZDB-PUB-031031-14
Zebrafish pronephros: A model for understanding cystic kidney disease
Hostetter, C.L., Sullivan-Brown, J.L., and Burdine, R.D.
Date: 2003
Source: Developmental dynamics : an official publication of the American Association of Anatomists   228(3): 514-522 (Review)
Registered Authors: Burdine, Rebecca, Hostetter, Christine, Sullivan-Brown, Jessica
Keywords: zebrafish, pronephros, cystic, kidney, asymmetry
MeSH Terms:
  • Animals
  • Body Patterning/physiology*
  • Kidney/abnormalities
  • Kidney/embryology*
  • Kidney Diseases, Cystic*
  • Models, Animal
  • Morphogenesis
  • Zebrafish/embryology*
PubMed: 14579389 Full text @ Dev. Dyn.
The embryonic kidney of the zebrafish is the pronephros. The ease of genetic analysis and experimentation in zebrafish, coupled with the simplicity of the pronephros, make the zebrafish an ideal model system for studying kidney development and function. Several mutations have been isolated in zebrafish genetic screens that result in cyst formation in the pronephros. Cloning and characterization of these mutations will provide insight into kidney development but may also provide understanding of the molecular basis of cystic kidney diseases. In this review, we focus on the zebrafish as a model for understanding cystic kidney disease and the links between cystic kidney disease and left-right patterning.