PUBLICATION

Cloning and characterization of a full-length pronociceptin in zebrafish: evidence of the existence of two different nociceptin sequences in the same precursor

Authors
Gonzalez-Nuñez, V., Gonzalez-Sarmiento, R., and Rodriguez, R.E.
ID
ZDB-PUB-031009-8
Date
2003
Source
BBA Gene Structure and Expression   1629(1-3): 114-118 (Journal)
Registered Authors
González Nuñez, Veronica, Rodriguez, Raquel E.
Keywords
none
MeSH Terms
  • Amino Acid Sequence
  • Animals
  • Brain/metabolism
  • Cloning, Molecular
  • Intestines/metabolism
  • Molecular Sequence Data
  • Opioid Peptides/genetics*
  • Protein Precursors/genetics*
  • Receptors, Opioid/genetics*
  • Sequence Alignment
  • Zebrafish/genetics*
PubMed
14522087 Full text @ BBA Gene Structure and Expression
Abstract
We report the cloning and molecular characterization of a zebrafish pronociceptin gene, which is expressed in brain and intestine. This fish precursor codes for two different nociceptin peptides, one of which presents an opioid sequence in its N-terminus, being more similar to dynorphin A than its mammalian counterparts. Our results represent a new tool to investigate the function of nociceptin and its receptor in relation to pain and drug addiction.
Genes / Markers
Figures
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Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping