PUBLICATION
A zebrafish unc-45 related gene expressed during muscle development
- Authors
- Etheridge, L., diIorio, P. and Sagerström, C.G.
- ID
- ZDB-PUB-020909-1
- Date
- 2002
- Source
- Developmental Dynamics : an official publication of the American Association of Anatomists 224(4): 457-460 (Journal)
- Registered Authors
- diIorio, Philip, Etheridge, Letitiah, Sagerström, Charles
- Keywords
- unc45r; unc-45; tetratricopeptide; CRO1; She4p; muscle; myosin; filament; Danio rerio
- MeSH Terms
-
- Muscle Development*
- Zebrafish Proteins/chemistry
- Zebrafish Proteins/genetics
- Zebrafish Proteins/metabolism
- Muscle Proteins/chemistry
- Muscle Proteins/genetics
- Muscle Proteins/metabolism
- Genes, Helminth
- Body Patterning
- Zebrafish/embryology*
- Zebrafish/genetics*
- Molecular Chaperones/chemistry
- Molecular Chaperones/genetics*
- Molecular Chaperones/metabolism
- Animals
- Humans
- Gene Expression Regulation, Developmental*
- Molecular Sequence Data
- Amino Acid Sequence
- Caenorhabditis elegans Proteins/genetics
- Muscles/embryology
- Muscles/metabolism*
- Sequence Alignment
- PubMed
- 12203738 Full text @ Dev. Dyn.
Citation
Etheridge, L., diIorio, P. and Sagerström, C.G. (2002) A zebrafish unc-45 related gene expressed during muscle development. Developmental Dynamics : an official publication of the American Association of Anatomists. 224(4):457-460.
Abstract
We report the isolation and expression pattern of zebrafish unc45r, a gene related to Caenorhabditis elegans unc-45. UNC-45 is a muscle- specific protein thought to interact with myosin and promote the assembly of muscle thick filaments during C. elegans development. Zebrafish Unc45r shares sequence features with C. elegans UNC-45, including three tetratricopeptide repeats and a CRO1/She4p homology domain. unc45r is expressed in mesoderm adjacent to the dorsal midline during late gastrula stages and is coexpressed with muscle specific genes in somitic mesoderm during development of trunk skeletal muscle. unc45r is also expressed in cranial skeletal muscle as well as in cardiac and smooth muscle. The isolation of a muscle-specific unc-45 related gene from zebrafish suggests a common mechanism for muscle filament assembly between vertebrates and invertebrates.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping