ZFIN ID: ZDB-PUB-001019-3
Expression of the Kruppel-like zinc finger gene biklf during zebrafish development
Kawahara, A. and Dawid, I.B.
Date: 2000
Source: Mechanisms of Development   97(1-2): 173-176 (Journal)
Registered Authors: Dawid, Igor B., Kawahara, Atsuo
Keywords: biklf; Kruppel-like factor; blood islands; BMP signaling
MeSH Terms:
  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • DNA, Complementary
  • DNA-Binding Proteins
  • Humans
  • Kruppel-Like Transcription Factors
  • Mice
  • Molecular Sequence Data
  • Repressor Proteins*
  • Sequence Homology, Amino Acid
  • Transcription Factors/genetics*
  • Zebrafish
  • Zebrafish Proteins*
  • Zinc Fingers*
PubMed: 11025220 Full text @ Mech. Dev.
The zebrafish biklf gene encodes a novel Kruppel-like transcription factor containing three contiguous zinc fingers at the C-terminus. Expression of biklf is detected from the shield stage onward in the developing prechordal plate, and as a 'baseball seam'-like lateral stripe beginning at the end of gastrulation. The latter expression domain is suppressed in the swirl mutant in which bmp2b is disrupted. At the 5-somite stage the lateral expression domain separates into two distinct stripes, one in the ectoderm, the other in blood islands in the lateral plate mesoderm. Blood island staining of biklf continues through somitogenesis as the most prominent area of biklf expression.