Expression of the Kruppel-like zinc finger gene biklf during zebrafish development
- Kawahara, A. and Dawid, I.B.
- Mechanisms of Development 97(1-2): 173-176 (Journal)
- Registered Authors
- Dawid, Igor B., Kawahara, Atsuo
- biklf; Kruppel-like factor; blood islands; BMP signaling
- MeSH Terms
- Amino Acid Sequence
- Base Sequence
- DNA, Complementary
- DNA-Binding Proteins
- Kruppel-Like Transcription Factors
- Molecular Sequence Data
- Repressor Proteins*
- Sequence Homology, Amino Acid
- Transcription Factors/genetics*
- Zebrafish Proteins*
- Zinc Fingers*
- 11025220 Full text @ Mech. Dev.
Kawahara, A. and Dawid, I.B. (2000) Expression of the Kruppel-like zinc finger gene biklf during zebrafish development. Mechanisms of Development. 97(1-2):173-176.
The zebrafish biklf gene encodes a novel Kruppel-like transcription factor containing three contiguous zinc fingers at the C-terminus. Expression of biklf is detected from the shield stage onward in the developing prechordal plate, and as a 'baseball seam'-like lateral stripe beginning at the end of gastrulation. The latter expression domain is suppressed in the swirl mutant in which bmp2b is disrupted. At the 5-somite stage the lateral expression domain separates into two distinct stripes, one in the ectoderm, the other in blood islands in the lateral plate mesoderm. Blood island staining of biklf continues through somitogenesis as the most prominent area of biklf expression.
Genes / Markers
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Engineered Foreign Genes