ZFIN Morpholino: MO1-cdc42

Target Location

Genome Build: GRCz11Chromosome: 11

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-cdc42

No data available

Phenotype

Phenotype resulting from MO1-cdc42

Phenotype	Fish	Figures
brain hydrocephalic, abnormal	WT + MO1-cdc42	Fig. 1, Fig. 2 from Choi et al., 2013
caudal fin curved, abnormal	WT + MO1-cdc42	Fig. 1 from Choi et al., 2013
caudal fin decreased length, abnormal	WT + MO1-cdc42	Fig. 1 from Choi et al., 2013
eye decreased size, abnormal	WT + MO1-cdc42	Fig. 1 from Choi et al., 2015 Fig. 1, Fig. 2 from Choi et al., 2013
melanosome transport delayed, abnormal	WT + MO1-cdc42	Fig. 6 from Choi et al., 2015

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Phenotype of all Fish created by or utilizing MO1-cdc42

Phenotype	Fish	Conditions	Figures
retinal ganglion cell layer apoptotic, abnormal	WT + MO1-cdc42	standard conditions	Fig. 3 from Choi et al., 2015
photoreceptor cell photoreceptor outer segment decreased length, abnormal	WT + MO1-cdc42	standard conditions	Fig. 4 from Choi et al., 2015
photoreceptor cell photoreceptor outer segment absent, abnormal	WT + MO1-cdc42	standard conditions	Fig. 4 from Choi et al., 2015 Fig. 2 from Choi et al., 2013
pronephric duct cilium disorganized, abnormal	WT + MO1-cdc42	standard conditions	Fig. 2 from Choi et al., 2013
renal glomerulus distended, abnormal	WT + MO1-cdc42	standard conditions	Fig. 2 from Choi et al., 2013

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Citations

Include unpublished citations

Block, J., Rashkova, C., Castanon, I., Zoghi, S., Platon, J., Ardy, R.C., Fujiwara, M., Chaves, B., Schoppmeyer, R., van der Made, C.I., Jimenez Heredia, R., Harms, F.L., Alavi, S., Alsina, L., Sanchez Moreno, P., Ávila Polo, R., Cabrera-Pérez, R., Kostel Bal, S., Pfajfer, L., Ransmayr, B., Mautner, A.K., Kondo, R., Tinnacher, A., Caldera, M., Schuster, M., Domínguez Conde, C., Platzer, R., Salzer, E., Boyer, T., Brunner, H.G., Nooitgedagt-Frons, J.E., Iglesias, E., Deyà-Martinez, A., Camacho-Lovillo, M., Menche, J., Bock, C., Huppa, J.B., Pickl, W.F., Distel, M., Yoder, J.A., Traver, D., Engelhardt, K.R., Linden, T., Kager, L., Hannich, J.T., Hoischen, A., Hambleton, S., Illsinger, S., Da Costa, L., Kutsche, K., Chavoshzadeh, Z., van Buul, J.D., Antón, J., Calzada-Hernández, J., Neth, O., Viaud, J., Nishikimi, A., Dupré, L., Boztug, K. (2023) Systemic Inflammation and Normocytic Anemia in DOCK11 Deficiency. The New England Journal of Medicine. 389(6):527-539
Baek, J.I., Kwon, S.H., Zuo, X., Kwon, S.Y., Kim, S.H., Lipschutz, J.H. (2016) Dynamin Binding Protein (Tuba) deficiency inhibits ciliogenesis and nephrogenesis in vitro and in vivo. The Journal of biological chemistry. 291(16):8632-43
Choi, S.Y., Baek, J.I., Zuo, X., Kim, S.H., Dunaief, J.L., Lipschutz, J.H. (2015) Cdc42 and sec10 Are Required for Normal Retinal Development in Zebrafish. Investigative ophthalmology & visual science. 56:3361-3370
Choi, S.Y., Chacon-Heszele, M.F., Huang, L., McKenna, S., Wilson, F.P., Zuo, X., and Lipschutz, J.H. (2013) Cdc42 Deficiency Causes Ciliary Abnormalities and Cystic Kidneys. Journal of the American Society of Nephrology : JASN. 24(9):1435-50

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