Gene
cdc42
- ID
- ZDB-GENE-030131-8783
- Name
- cell division cycle 42
- Symbol
- cdc42 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to have GTP binding activity; GTPase activity; and protein kinase binding activity. Involved in several processes, including eye development; melanosome transport; and plasma membrane bounded cell projection assembly. Predicted to localize to several cellular components, including cell cortex; cytoplasmic vesicle; and cytoskeleton. Human ortholog(s) of this gene implicated in fibrosarcoma. Is expressed in blastodisc; brain; eye; and pronephros. Orthologous to human CDC42 (cell division cycle 42).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 9 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Takenouchi-Kosaki syndrome | 616737 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Cdc42 | P-loop containing nucleoside triphosphate hydrolase | Small GTPase | Small GTPase Rho | Small GTP-binding protein domain |
|---|---|---|---|---|---|---|
|
UniProtKB:Q52WY2
|
191 | |||||
|
UniProtKB:Q6PFU4
|
191 |
Interactions and Pathways
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-cdc42 | polyclonal | IgG | Rabbit |
|
Santa Cruz Biotechnology, Inc.
|
3 |
Plasmids