Morpholino
MO1-araf
- ID
- ZDB-MRPHLNO-130508-1
- Name
- MO1-araf
- Previous Names
- None
- Target
- Sequence
-
5' - GACACTCACAAAGATTTACACAGCG - 3'
- Disclaimer
- Although ZFIN verifies reagent sequence data, we recommend that you conduct independent sequence analysis before ordering any reagent.
- Note
-
Translation-blocking MO.
- Genome Resources
- None
Target Location
Genomic Features
No data available
Expression
Gene expression in Wild Types + MO1-araf
No data available
Phenotype
Phenotype resulting from MO1-araf
Phenotype | Fish | Figures |
---|---|---|
whole organism wholly dorsalized, abnormal | TU + MO1-araf |
Fig. S3
from Liu et al., 2013 |
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Phenotype of all Fish created by or utilizing MO1-araf
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Citations
- Xiong, C., Liu, X., Meng, A. (2015) The Kinase Activity-deficient Isoform of the Protein Araf Antagonizes Ras/Mitogen-activated Protein Kinase (Ras/MAPK) Signaling in the Zebrafish Embryo. The Journal of biological chemistry. 290(42):25512-21
- Liu, X., Xiong, C., Jia, S., Zhang, Y., Chen, Y.G., Wang, Q., and Meng, A. (2013) Araf kinase antagonizes Nodal-Smad2 activity in mesendoderm development by directly phosphorylating the Smad2 linker region. Nature communications. 4:1728
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