Gene
araf
- ID
- ZDB-GENE-050102-2
- Name
- A-Raf proto-oncogene, serine/threonine kinase
- Symbol
- araf Nomenclature History
- Previous Names
-
- sb:eu994
- wu:fk45h07
- zgc:92074
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Exhibits SMAD binding activity. Involved in negative regulation of nodal signaling pathway and pathway-restricted SMAD protein phosphorylation. Predicted to localize to cytosol and mitochondrion. Is expressed in head. Orthologous to human ARAF (A-Raf proto-oncogene, serine/threonine kinase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu994 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
| Domain | IPR002219 | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain |
| Domain | IPR003116 | Raf-like Ras-binding |
| Domain | IPR020454 | Diacylglycerol/phorbol-ester binding |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR029071 | Ubiquitin-like domain superfamily |
| Homologous_superfamily | IPR046349 | C1-like domain superfamily |
Domain Details Per Protein
| Protein | Length | C1-like domain superfamily | Diacylglycerol/phorbol-ester binding | Protein kinase, ATP binding site | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain | Protein kinase domain | Protein kinase-like domain superfamily | Raf-like Ras-binding | Serine/threonine-protein kinase, active site | Serine-threonine/tyrosine-protein kinase, catalytic domain | Ubiquitin-like domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q5FBD1
|
608 | ||||||||||
|
UniProtKB:Q5M7Y2
|
604 | ||||||||||
|
UniProtKB:Q75Y03
|
608 |
Interactions and Pathways
No data available
Plasmids
No data available