Morpholino

MO2-lrrk2

ID

ZDB-MRPHLNO-100520-5

Name

MO2-lrrk2

Previous Names

Target

Sequence

5' - GCTCCTGAAACACAGCATTAGGAAC - 3'

Disclaimer

Although ZFIN verifies reagent sequence data, we recommend that you conduct independent sequence analysis before ordering any reagent.

Note

splice-blocking MO targeted to intron 44 splice acceptor junction, designed to delete exon 45, introducing a premature stop codon in the WD40 domain.

Genome Resources

None

Target Location

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO2-lrrk2

No data available

Phenotype

Phenotype resulting from MO2-lrrk2

No data available

Phenotype of all Fish created by or utilizing MO2-lrrk2

Phenotype	Fish	Conditions	Figures
embryo development delayed, abnormal	AB + MO1-lrrk2 + MO2-lrrk2	standard conditions	Fig. Table 1 from Ren et al., 2011
diencephalon dopaminergic neuron irregular spatial pattern, abnormal	AB + MO1-lrrk2 + MO2-lrrk2	standard conditions	Fig. 3 from Ren et al., 2011
optic tectum neuron decreased amount, abnormal	WT + MO1-lrrk2 + MO2-lrrk2	standard conditions	Fig. 4 from Sheng et al., 2010
neuron apoptotic process increased occurrence, abnormal	WT + MO1-lrrk2 + MO2-lrrk2	standard conditions	Fig. 3 from Sheng et al., 2010
optic tectum axon decreased amount, abnormal	WT + MO1-lrrk2 + MO2-lrrk2	standard conditions	Fig. 4 from Sheng et al., 2010
locomotion decreased occurrence, abnormal	WT + MO1-lrrk2 + MO2-lrrk2	standard conditions	Fig. 6 from Sheng et al., 2010
diencephalon dopaminergic neuron decreased amount, abnormal	WT + MO1-lrrk2 + MO2-lrrk2	standard conditions	Fig. 3 , Fig. 5 from Sheng et al., 2010
midbrain neuron decreased amount, abnormal	kca2Tg; rk8Tg + MO1-lrrk2 + MO2-lrrk2	standard conditions	Fig. 3 from Sheng et al., 2010

Citations