Gene

lrrk2

ID
ZDB-GENE-071218-6
Name
leucine-rich repeat kinase 2
Symbol
lrrk2 Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 25 Mapping Details/Browsers
Description
Is predicted to enable several functions, including SNARE binding activity; protein kinase A binding activity; and protein serine/threonine phosphatase activity. Involved in several processes, including protein localization to endoplasmic reticulum exit site; regulation of autophagy; and regulation of signal transduction. Acts upstream of or within cell differentiation and phosphorylation. Is expressed in gut; heart; muscle; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in Crohn's disease; Parkinson's disease; Parkinson's disease 8; Parkinsonism; and cancer. Orthologous to human LRRK2 (leucine rich repeat kinase 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
10 figures from 7 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
15 figures from 5 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With lrrk2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Parkinson's disease 8 Alliance {Parkinson disease 8} 607060
Associated With lrrk2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008271 Serine/threonine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Domain IPR000719 Protein kinase domain
Domain IPR020859 Roc domain
Domain IPR032171 C-terminal of Roc (COR) domain
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Homologous_superfamily IPR011989 Armadillo-like helical
Homologous_superfamily IPR015943 WD40/YVTN repeat-like-containing domain superfamily
Homologous_superfamily IPR016024 Armadillo-type fold
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily IPR032675 Leucine-rich repeat domain superfamily
Homologous_superfamily IPR036322 WD40-repeat-containing domain superfamily
Homologous_superfamily IPR036770 Ankyrin repeat-containing domain superfamily
Repeat IPR001611 Leucine-rich repeat
Repeat IPR003591 Leucine-rich repeat, typical subtype
Repeat IPR025875 Leucine rich repeat 4
Domain Details Per Protein
Protein Length Ankyrin repeat-containing domain superfamily Armadillo-like helical Armadillo-type fold C-terminal of Roc (COR) domain Leucine-rich repeat Leucine rich repeat 4 Leucine-rich repeat domain superfamily Leucine-rich repeat, typical subtype P-loop containing nucleoside triphosphate hydrolase Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily Roc domain Serine/threonine-protein kinase, active site WD40-repeat-containing domain superfamily WD40/YVTN repeat-like-containing domain superfamily
UniProtKB:F8W598 2532
UniProtKB:D9IG64 2533
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-lrrk2
  • WB
1
Ab2-lrrk2 monoclonal IgG Rabbit
  • IHC
  • WB
Abcam plc
2
Plasmids
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations