ZFIN Morpholino: MO4-mmp9

Target Location

Genome Build: GRCz11Chromosome: 8

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO4-mmp9

No data available

Phenotype

Phenotype resulting from MO4-mmp9

No data available

Phenotype of all Fish created by or utilizing MO4-mmp9

Phenotype	Fish	Conditions	Figures
ventricular system macrophage migration decreased occurrence, abnormal	AB + MO4-mmp9	germ free, bacterial treatment by injection: Listeria monocytogenes EGD-e	Fig. 6 from Shan et al., 2016
gut blood increased amount, abnormal	AB + MO4-mmp9	bacterial treatment by exposure to environment: Listeria monocytogenes EGD-e, germ free	Fig. 4 from Shan et al., 2016
fin regeneration process quality, abnormal	WT + MO4-mmp9	amputation: caudal fin	Fig. 5 from LeBert et al., 2015
regenerating fin decreased length, abnormal	WT + MO4-mmp9	amputation: caudal fin	Fig. 6 from LeBert et al., 2015
regenerating fin fibrillar collagen trimer thickness, abnormal	WT + MO4-mmp9	amputation: caudal fin	Fig. 5 from LeBert et al., 2015

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Citations

Include unpublished citations

Huang, Y., Yu, S.H., Zhen, W.X., Cheng, T., Wang, D., Lin, J.B., Wu, Y.H., Wang, Y.F., Chen, Y., Shu, L.P., Wang, Y., Sun, X.J., Zhou, Y., Yang, F., Hsu, C.H., Xu, P.F. (2021) Tanshinone I, a new EZH2 inhibitor restricts normal and malignant hematopoiesis through upregulation of MMP9 and ABCG2. Theranostics. 11:6891-6904
Eshwar, A.K., Wolfrum, N., Stephan, R., Fanning, S., Lehner, A. (2018) Interaction of matrix metalloproteinase-9 and Zpx in Cronobacter turicensis LMG 23827^T mediated infections in the zebrafish model.. Cellular Microbiology. 20(11):e12888
Theodore, L.N., Hagedorn, E.J., Cortes, M., Natsuhara, K., Liu, S.Y., Perlin, J.R., Yang, S., Daily, M.L., Zon, L.I., North, T.E. (2017) Distinct Roles for Matrix Metalloproteinases 2 and 9 in Embryonic Hematopoietic Stem Cell Emergence, Migration, and Niche Colonization. Stem Cell Reports. 8(5):1226-1241
Hatzold, J., Beleggia, F., Herzig, H., Altmüller, J., Nürnberg, P., Bloch, W., Wollnik, B., Hammerschmidt, M. (2016) Tumor suppression in basal keratinocytes via dual non-cell-autonomous functions of a Na,K-ATPase beta subunit. eLIFE. 5:e14277
Shan, Y., Zhang, Y., Zhuo, X., Li, X., Peng, J., Fang, W. (2016) Matrix metalloproteinase-9 plays a role in protecting zebrafish from lethal infection with Listeria monocytogenes by enhacing macrophage migration. Fish & shellfish immunology. 54:179-87
LeBert, D.C., Squirrell, J.M., Rindy, J., Broadbridge, E., Lui, Y., Zakrzewska, A., Eliceiri, K.W., Meijer, A.H., Huttenlocher, A. (2015) Matrix metalloproteinase 9 modulates collagen matrices and wound repair. Development (Cambridge, England). 142(12):2136-46
Volkman, H.E., Pozos, T.C., Zheng, J., Davis, J.M., Rawls, J.F., and Ramakrishnan, L. (2010) Tuberculous Granuloma Induction via Interaction of a Bacterial Secreted Protein with Host Epithelium. Science (New York, N.Y.). 327(5964):466-469

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