Gene
mmp9
- ID
- ZDB-GENE-040426-2132
- Name
- matrix metallopeptidase 9
- Symbol
- mmp9 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to have metalloendopeptidase activity. Involved in several processes, including collagen fibril organization; fin regeneration; and positive regulation of granuloma formation. Predicted to localize to extracellular space. Human ortholog(s) of this gene implicated in several diseases, including Down syndrome; anodontia; artery disease (multiple); autoimmune hypersensitivity disease (multiple); and lung disease (multiple). Is expressed in several structures, including cardiovascular system; female organism; head; hematopoietic cell; and hematopoietic system. Orthologous to human MMP9 (matrix metallopeptidase 9).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 144 figures from 104 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:64165 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Metaphyseal anadysplasia 2 | 613073 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR021158 | Peptidase M10A, cysteine switch, zinc binding site |
| Domain | IPR000562 | Fibronectin type II domain |
| Domain | IPR000585 | Hemopexin-like domain |
| Domain | IPR001818 | Peptidase M10, metallopeptidase |
| Domain | IPR006026 | Peptidase, metallopeptidase |
| Domain | IPR033739 | Peptidase M10A, catalytic domain |
| Family | IPR021190 | Peptidase M10A |
| Homologous_superfamily | IPR013806 | Kringle-like fold |
| Homologous_superfamily | IPR024079 | Metallopeptidase, catalytic domain superfamily |
| Homologous_superfamily | IPR036365 | PGBD-like superfamily |
| Homologous_superfamily | IPR036375 | Hemopexin-like domain superfamily |
| Homologous_superfamily | IPR036943 | Fibronectin type II domain superfamily |
| Repeat | IPR018487 | Hemopexin-like repeats |
Domain Details Per Protein
| Protein | Length | Fibronectin type II domain | Fibronectin type II domain superfamily | Hemopexin-like domain | Hemopexin-like domain superfamily | Hemopexin-like repeats | Kringle-like fold | Metallopeptidase, catalytic domain superfamily | Peptidase M10A | Peptidase M10A, catalytic domain | Peptidase M10A, cysteine switch, zinc binding site | Peptidase M10, metallopeptidase | Peptidase, metallopeptidase | PGBD-like superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q7T317
|
680 |
Interactions and Pathways
No data available
Plasmids
No data available