ZFIN Morpholino: MO2-nkx2.5

Target Location

Genome Build: GRCz11Chromosome: 14

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO2-nkx2.5

No data available

Phenotype

Phenotype resulting from MO2-nkx2.5

Phenotype	Fish	Figures
atrium shape, abnormal	WT + MO2-nkx2.5	Fig. 1 from Targoff et al., 2008
basihyal cartilage decreased size, abnormal	WT + MO2-nkx2.5 + MO4-tp53	Fig. 5, text only from Iklé et al., 2017
cardiac ventricle decreased size, abnormal	WT + MO2-nkx2.5	Fig. 1 from Targoff et al., 2008
ceratobranchial cartilage hypoplastic, abnormal	WT + MO2-nkx2.5	Fig. 5, text only from Iklé et al., 2017
cranial cartilage hypoplastic, abnormal	WT + MO2-nkx2.5 + MO4-tp53	Fig. 5, Fig. 7, text only from Iklé et al., 2017

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Phenotype of all Fish created by or utilizing MO2-nkx2.5

Phenotype	Fish	Conditions	Figures
whole organism gdf3 expression decreased amount, abnormal	AB + MO2-nkx2.5	standard conditions	Fig. 2 from Gao et al., 2019
pharyngeal arch 3 hand2 expression decreased distribution, abnormal	WT + MO2-nkx2.5	standard conditions	Fig. 6 from Iklé et al., 2017
palatoquadrate cartilage malformed, abnormal	WT + MO2-nkx2.5	standard conditions	Fig. 5 from Iklé et al., 2017
pharyngeal arch 1 dlx3b expression absent, abnormal	WT + MO2-nkx2.5	standard conditions	Fig. 6 from Iklé et al., 2017
pharyngeal arch edn1 expression decreased distribution, abnormal	WT + MO2-nkx2.5	standard conditions	Fig. 6 from Iklé et al., 2017

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Citations

Include unpublished citations

Bornhorst, D., Xia, P., Nakajima, H., Dingare, C., Herzog, W., Lecaudey, V., Mochizuki, N., Heisenberg, C.P., Yelon, D., Abdelilah-Seyfried, S. (2019) Biomechanical signaling within the developing zebrafish heart attunes endocardial growth to myocardial chamber dimensions. Nature communications. 10:4113
Gao, X., Zheng, P., Yang, L., Luo, H., Zhang, C., Qiu, Y., Huang, G., Sheng, W., Ma, X., Lu, C. (2019) Association of functional variant in GDF1 promoter with risk of congenital heart disease and its regulation by Nkx2.5. Clinical science (London, England : 1979). 133:1281-1295
Iklé, J.M., Tavares, A.L., King, M., Ding, H., Colombo, S., Firulli, B.A., Fiulli, A.B., Targoff, K.L., Yelon, D., Clouthier, D.E. (2017) Nkx2.5 regulates Endothelin Converting Enzyme-1 during pharyngeal arch patterning. Genesis (New York, N.Y. : 2000). 55(3)
Witzel, H.R., Jungblut, B., Choe, C.P., Crump, J.G., Braun, T., and Dobreva, G. (2012) The LIM Protein Ajuba Restricts the Second Heart Field Progenitor Pool by Regulating Isl1 Activity. Developmental Cell. 23(1):58-70
Tu, C.T., Yang, T.C., and Tsai, H.J. (2009) Nkx2.7 and Nkx2.5 function redundantly and are required for cardiac morphogenesis of zebrafish embryos. PLoS One. 4(1):e4249
Targoff, K.L., Schell, T., and Yelon, D. (2008) Nkx genes regulate heart tube extension and exert differential effects on ventricular and atrial cell number. Developmental Biology. 322(2):314-321

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