ZFIN Morpholino: MO1-tnfa

Target Location

Genome Build: GRCz11Chromosome: 19

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-tnfa

No data available

Phenotype

Phenotype resulting from MO1-tnfa

No data available

Phenotype of all Fish created by or utilizing MO1-tnfa

Phenotype	Fish	Conditions	Figures
caudal hematopoietic tissue EGFP expression amount, ameliorated	la2Tg/la2Tg + CRISPR1-ada2b + CRISPR2-ada2b + MO1-tnfa	standard conditions	Fig. 5 from Brix et al., 2024
caudal hematopoietic tissue neutrophil decreased amount, ameliorated	la2Tg/la2Tg + CRISPR1-ada2b + CRISPR2-ada2b + MO1-tnfa	standard conditions	Fig. 5 from Brix et al., 2024
retinal inner nuclear layer cell population proliferation decreased process quality, abnormal	slc45a2^{unspecified/unspecified} + MO1-tnfa	constant light, high light intensity	Fig. 6, Fig. 7 from Nelson et al., 2013
photoreceptor cell regeneration process quality, abnormal	slc45a2^{unspecified/unspecified} + MO1-tnfa	constant light, high light intensity	Fig. 11 from Nelson et al., 2013
retinal inner nuclear layer cell population proliferation decreased process quality, abnormal	slc45a2^{unspecified/unspecified} + MO1-tnfa	chemical treatment: pharmaceutical	Fig. 13 from Nelson et al., 2013

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Citations

Include unpublished citations

Brix, A., Belleri, L., Pezzotta, A., Pettinato, E., Mazzola, M., Zoccolillo, M., Marozzi, A., Monteiro, R., Del Bene, F., Mortellaro, A., Pistocchi, A. (2024) ADA2 regulates inflammation and hematopoietic stem cell emergence via the A_2bR pathway in zebrafish. Communications biology. 7:615615
Lu, C., Hyde, D.R. (2024) Cytokines IL-1β and IL-10 are required for Müller glia proliferation following light damage in the adult zebrafish retina. Frontiers in cell and developmental biology. 12:14063301406330
Lin, J., Zhan, G., Liu, J., Maimaitiyiming, Y., Deng, Z., Li, B., Su, K., Chen, J., Sun, S., Zheng, W., Yu, X., He, F., Cheng, X., Wang, L., Shen, B., Yao, Z., Yang, X., Zhang, J., He, W., Wu, H., Naranmandura, H., Chang, K.J., Min, J., Ma, J., Björklund, M., Xu, P.F., Wang, F., Hsu, C.H. (2023) YTHDF2-mediated regulations bifurcate BHPF-induced programmed cell deaths. National science review. 10:nwad227nwad227
Hall, C.J., Sanderson, L.E., Lawrence, L.M., Pool, B., van der Kroef, M., Ashimbayeva, E., Britto, D., Harper, J.L., Lieschke, G.J., Astin, J.W., Crosier, K.E., Dalbeth, N., Crosier, P.S. (2018) Blocking fatty acid-fueled mROS production within macrophages alleviates acute gouty inflammation. The Journal of Clinical Investigation. 128(5):1752-1771
Nelson, C.M., Ackerman, K.M., O'Hayer, P., Bailey, T.J., Gorsuch, R.A., and Hyde, D.R. (2013) Tumor Necrosis Factor-Alpha Is Produced by Dying Retinal Neurons and Is Required for Muller Glia Proliferation during Zebrafish Retinal Regeneration. The Journal of neuroscience : the official journal of the Society for Neuroscience. 33(15):6524-6539
Matthews, R.P., Lorent, K., Mañoral-Mobias, R., Huang, Y., Gong, W., Murray, I.V., Blair, I.A., and Pack, M. (2009) TNF{alpha}-dependent hepatic steatosis and liver degeneration caused by mutation of zebrafish s-adenosylhomocysteine hydrolase. Development (Cambridge, England). 136(5):865-875

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