ZFIN Morpholino: MO1-pou5f3

Target Location

Genome Build: GRCz11Chromosome: 21

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-pou5f3

No data available

Phenotype

Phenotype resulting from MO1-pou5f3

Phenotype	Fish	Figures
chromatin organization process quality, abnormal	TU + MO1-pou5f3	Fig. 4 from Liu et al., 2018
neuroectoderm hoxb1b expression decreased amount, abnormal	WT + MO1-pou5f3	Fig. 5 from Dong et al., 2017

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Phenotype of all Fish created by or utilizing MO1-pou5f3

Phenotype	Fish	Conditions	Figures
fin regeneration decreased process quality, abnormal	AB + MO1-pou5f3	amputation: caudal fin	Fig. 7 from Ha et al., 2022
fin regeneration delayed, abnormal	AB + MO1-pou5f3	physical alteration: anatomical structure	Fig. 4 from Christen et al., 2010
chromatin organization process quality, abnormal	TU + MO1-pou5f3	standard conditions	Fig. 4 from Liu et al., 2018
neuroectoderm hoxb1b expression decreased amount, abnormal	WT + MO1-pou5f3	standard conditions	Fig. 5 from Dong et al., 2017
digestive tract mesoderm development temporally extended, abnormal	apc^hu745/hu745 + MO1-pou5f3	standard conditions	Fig. 3 from Rai et al., 2010

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Citations

Include unpublished citations

Ha, J., Kim, B.S., Min, B., Nam, J., Lee, J.G., Lee, M., Yoon, B.H., Choi, Y.H., Im, I., Park, J.S., Choi, H., Baek, A., Cho, S.M., Lee, M.O., Nam, K.H., Mun, J.Y., Kim, M., Kim, S.Y., Son, M.Y., Kang, Y.K., Lee, J.S., Kim, J.K., Kim, J. (2022) Intermediate cells of in vitro cellular reprogramming and in vivo tissue regeneration require desmoplakin. Science advances. 8:eabk1239
Liu, G., Wang, W., Hu, S., Wang, X., Zhang, Y. (2018) Inherited DNA methylation primes the establishment of accessible chromatin during genome activation. Genome research. 28(7):998-1007
Dong, X., Li, J., He, L., Gu, C., Jia, W., Yue, Y., Li, J., Zhang, Q., Chu, L., Zhao, Q. (2017) Zebrafish Znfl1 proteins control the expression of hoxb1b gene in the posterior neuroectoderm by acting upstream of pou5f3 and sall4 genes.. The Journal of biological chemistry. 292(31):13045-13055
Joseph, S.R., Pálfy, M., Hilbert, L., Kumar, M., Karschau, J., Zaburdaev, V., Shevchenko, A., Vastenhouw, N.L. (2017) Competition between histone and transcription factor binding regulates the onset of transcription in zebrafish embryos. eLIFE. 6
Christen, B., Robles, V., Raya, M., Paramonov, I., and Izpisúa Belmonte, J.C. (2010) Regeneration and reprogramming compared. BMC Biology. 8:5
Rai, K., Sarkar, S., Broadbent, T.J., Voas, M., Grossmann, K.F., Nadauld, L.D., Dehghanizadeh, S., Hagos, F.T., Li, Y., Toth, R.K., Chidester, S., Bahr, T.M., Johnson, W.E., Sklow, B., Burt, R., Cairns, B.R., and Jones, D.A. (2010) DNA demethylase activity maintains intestinal cells in an undifferentiated state following loss of APC. Cell. 142(6):930-942
Chan, T.M., Chao, C.H., Wang, H.D., Yu, Y.J., and Yuh, C.H. (2009) Functional analysis of the evolutionarily conserved Cis-regulatory elements on the Sox17 gene in zebrafish. Developmental Biology. 326(2):456-470
Parvin, M.S., Okuyama, N., Inoue, F., Islam, M.E., Kawakami, A., Takeda, H., and Yamasu, K. (2008) Autoregulatory loop and retinoic acid repression regulate pou2/pou5f1 gene expression in the zebrafish embryonic brain. Developmental Dynamics : an official publication of the American Association of Anatomists. 237(5):1373-1388
Burgess, S., Reim, G., Chen, W., Hopkins, N., and Brand, M. (2002) The zebrafish spiel-ohne-grenzen (spg) gene encodes the POU domain protein Pou2 related to mammalian Oct4 and is essential for formation of the midbrain and hindbrain, and for pre-gastrula morphogenesis. Development (Cambridge, England). 129(4):905-916

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