ZFIN Morpholino: MO1-tmem67

Target Location

Genome Build: GRCz11Chromosome: 16

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-tmem67

No data available

Phenotype

Phenotype resulting from MO1-tmem67

Phenotype	Fish	Figures
brain malformed, abnormal	WT + MO1-tmem67	Fig. S5 from Adams et al., 2012
brain morphology, abnormal	AB + MO1-tmem67	Fig. 5 from Stayner et al., 2017
cilium assembly decreased process quality, abnormal	WT + MO1-tmem67	Fig. 5, Fig. S5 from Adams et al., 2012
eye decreased size, abnormal	WT + MO1-tmem67	Fig. S5 from Adams et al., 2012
eye malformed, abnormal	WT + MO1-tmem67	Fig. S5 from Adams et al., 2012

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Phenotype of all Fish created by or utilizing MO1-tmem67

Phenotype	Fish	Conditions	Figures
somite increased width, abnormal	AB + MO1-tmem67	standard conditions	Fig. 5 from Stayner et al., 2017
brain morphology, abnormal	AB + MO1-tmem67	standard conditions	Fig. 5 from Stayner et al., 2017
notochord kinked, abnormal	AB + MO1-tmem67	standard conditions	Fig. 5 from Stayner et al., 2017
notochord morphology, abnormal	AB + MO1-tmem67	standard conditions	Fig. 5 from Stayner et al., 2017
hindbrain hydrocephalic, abnormal	AB + MO1-tmem67	standard conditions	Fig. S2 from Lee et al., 2017

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Citations

Include unpublished citations

Lee, S.H., Nam, T.S., Li, W., Kim, J.H., Yoon, W., Choi, Y.D., Kim, K.H., Cai, H., Kim, M.J., Kim, C., Choy, H.E., Kim, N., Chay, K.O., Kim, M.K., Choi, S.Y. (2017) Functional validation of novel MKS3/TMEM67 mutations in COACH syndrome. Scientific Reports. 7:10222
Stayner, C., Poole, C.A., McGlashan, S.R., Pilanthananond, M., Brauning, R., Markie, D., Lett, B., Slobbe, L., Chae, A., Johnstone, A.C., Jensen, C.G., McEwan, J.C., Dittmer, K., Parker, K., Wiles, A., Blackburne, W., Leichter, A., Leask, M., Pinnapureddy, A., Jennings, M., Horsfield, J.A., Walker, R.J., Eccles, M.R. (2017) An ovine hepatorenal fibrocystic model of a Meckel-like syndrome associated with dysmorphic primary cilia and TMEM67 mutations. Scientific Reports. 7:1601
Adams, M., Simms, R.J., Abdelhamed, Z., Dawe, H.R., Szymanska, K., Logan, C.V., Wheway, G., Pitt, E., Gull, K., Knowles, M.A., Blair, E., Cross, S.H., Sayer, J.A., and Johnson, C.A. (2012) A meckelin-filamin A interaction mediates ciliogenesis. Human molecular genetics. 21(6):1272-1286
Valente, E.M., Logan, C.V., Mougou-Zerelli, S., Lee, J.H., Silhavy, J.L., Brancati, F., Iannicelli, M., Travaglini, L., Romani, S., Illi, B., Adams, M., Szymanska, K., Mazzotta, A., Lee, J.E., Tolentino, J.C., Swistun, D., Salpietro, C.D., Fede, C., Gabriel, S., Russ, C., Cibulskis, K., Sougnez, C., Hildebrandt, F., Otto, E.A., Held, S., Diplas, B.H., Davis, E.E., Mikula, M., Strom, C.M., Ben-Zeev, B., Lev, D., Sagie, T.L., Michelson, M., Yaron, Y., Krause, A., Boltshauser, E., Elkhartoufi, N., Roume, J., Shalev, S., Munnich, A., Saunier, S., Inglehearn, C., Saad, A., Alkindy, A., Thomas, S., Vekemans, M., Dallapiccola, B., Katsanis, N., Johnson, C.A., Attié-Bitach, T., and Gleeson, J.G. (2010) Mutations in TMEM216 perturb ciliogenesis and cause Joubert, Meckel and related syndromes. Nature Genetics. 42(7):619-625
Leitch, C.C., Zaghloul, N.A., Davis, E.E., Stoetzel, C., Diaz-Font, A., Rix, S., Al-Fadhel, M., Lewis, R.A., Eyaid, W., Banin, E., Dollfus, H., Beales, P.L., Badano, J.L., and Katsanis, N. (2008) Hypomorphic mutations in syndromic encephalocele genes are associated with Bardet-Biedl syndrome. Nature Genetics. 40(4):443-448
Tobin, J.L., and Beales, P.L. (2008) Restoration of renal function in zebrafish models of ciliopathies. Pediatric nephrology (Berlin, Germany). 23(11):2095-2099

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