ZFIN Morpholino: MO2-cdh5

Target Location

Genome Build: GRCz11Chromosome: 7

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO2-cdh5

No data available

Phenotype

Phenotype resulting from MO2-cdh5

Phenotype	Fish	Figures
brain blood vessel broken, abnormal	s843Tg + MO2-cdh5	Fig. S5 from Xu et al., 2017
cranial vasculature hemorrhagic, abnormal	AB + MO2-cdh5	Fig. 2 , Fig. S5 from Xu et al., 2017
intersegmental vessel branchiness, abnormal	y1Tg + MO2-cdh5	Fig. 1 , text only from Abraham et al., 2009
nucleate erythrocyte decreased amount, abnormal	WT + MO2-cdh5	Fig. S1 from Anderson et al., 2015
sprouting angiogenesis increased occurrence, abnormal	y1Tg + MO2-cdh5	Fig. 1 , text only from Abraham et al., 2009

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Phenotype of all Fish created by or utilizing MO2-cdh5

Phenotype	Fish	Conditions	Figures
cranial vasculature hemorrhagic, abnormal	AB + MO2-cdh5	standard conditions	Fig. S5 from Xu et al., 2017
nucleate erythrocyte decreased amount, abnormal	WT + MO2-cdh5	standard conditions	Fig. S1 from Anderson et al., 2015
whole organism cdh5 expression decreased amount, abnormal	WT + MO2-cdh5	standard conditions	Fig. S1 from Anderson et al., 2015
cranial vasculature hemorrhagic, abnormal	s843Tg + MO2-cdh5	standard conditions	Fig. 2 from Xu et al., 2017
brain blood vessel broken, abnormal	s843Tg + MO2-cdh5	standard conditions	Fig. S5 from Xu et al., 2017

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Citations

Include unpublished citations

Xu, B., Zhang, Y., Du, X.F., Li, J., Zi, H.X., Bu, J.W., Yan, Y., Han, H., Du, J.L. (2017) Neurons secrete miR-132-containing exosomes to regulate brain vascular integrity. Cell Research. 27(7):882-897
Meng, P., Liu, Y., Chen, X., Zhang, W., Zhang, Y. (2016) Zebrafish Cdh5 negatively regulates mobilization of aorta-gonad-mesonephros-derived hematopoietic stem cells. Journal of genetics and genomics = Yi chuan xue bao. 43(10):613-616
Anderson, H., Patch, T.C., Reddy, P.N., Hagedorn, E.J., Kim, P.G., Soltis, K.A., Chen, M.J., Tamplin, O.J., Frye, M., MacLean, G.A., Hübner, K., Bauer, D.E., Kanki, J.P., Vogin, G., Huston, N.C., Nguyen, M., Fujiwara, Y., Paw, B.H., Vestweber, D., Zon, L.I., Orkin, S.H., Daley, G.Q., Shah, D.I. (2015) Hematopoietic stem cells develop in the absence of endothelial cadherin 5 expression. Blood. 126(26):2811-20
Abraham, S., Yeo, M., Montero-Balaguer, M., Paterson, H., Dejana, E., Marshall, C.J., and Mavria, G. (2009) VE-Cadherin-Mediated Cell-Cell Interaction Suppresses Sprouting via Signaling to MLC2 Phosphorylation. Current biology : CB. 19(8):668-674
Montero-Balaguer, M., Swirsding, K., Orsenigo, F., Cotelli, F., Mione, M., and Dejana, E. (2009) Stable vascular connections and remodeling require full expression of VE-cadherin in zebrafish embryos. PLoS One. 4(6):e5772

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