ZFIN Morpholino: MO3-tbxta

Target Location

Genome Build: GRCz11Chromosome: 19

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO3-tbxta

No data available

Phenotype

Phenotype resulting from MO3-tbxta

Phenotype	Fish	Figures
determination of heart left/right asymmetry decreased process quality, abnormal	twu34Tg + MO3-tbxta	Fig. 4 from Veerkamp et al., 2013
primitive heart tube bilateral symmetry, abnormal	twu34Tg + MO3-tbxta	Fig. 4 from Veerkamp et al., 2013

1 - 2 of 2

Phenotype of all Fish created by or utilizing MO3-tbxta

Phenotype	Fish	Conditions	Figures
notochord development disrupted, abnormal	WT + MO3-tbxta	ultraviolet light	Fig. S2 from Shestopalov et al., 2007
notochord aplastic, abnormal	WT + MO3-tbxta	ultraviolet light	Fig. S2 from Shestopalov et al., 2007
notochord morphology, abnormal	WT + MO3-tbxta	ultraviolet light	Fig. 2, Fig. S2 from Shestopalov et al., 2007
somite U-shaped, abnormal	WT + MO3-tbxta	ultraviolet light	Fig. 2, Fig. S2 from Shestopalov et al., 2007
post-vent region malformed, abnormal	WT + MO3-tbxta	ultraviolet light	Fig. 1, Fig. S2 from Shestopalov et al., 2007

1 - 5 of 7 Show all

Citations

Include unpublished citations

Das, U., Kundu, J., Shaw, P., Bose, C., Ghosh, A., Gupta, S., Sarkar, S., Bhadra, J., Sinha, S. (2023) Self-transfecting GMO-PMO chimera targeting Nanog enable gene silencing in vitro and suppresses tumor growth in 4T1 allografts in mouse. Molecular therapy. Nucleic acids. 32:203228203-228
Kundu, J., Ghosh, A., Ghosh, U., Das, A., Nagar, D., Pattanayak, S., Ghose, A., Sinha, S. (2022) Synthesis of Phosphorodiamidate Morpholino Oligonucleotides Using Trityl and Fmoc Chemistry in an Automated Oligo Synthesizer. The Journal of organic chemistry. 87(15):9466-9478
Pattanayak, S., Sarode, B.R., Deiters, A., Chen, J.K. (2022) Bicyclic Caged Morpholino Oligonucleotides for Optical Gene Silencing. Chembiochem : a European journal of chemical biology. 23(21):e202200374
Darrah, K., Wesalo, J., Lukasak, B., Tsang, M., Chen, J.K., Deiters, A. (2021) Small Molecule Control of Morpholino Antisense Oligonucleotide Function through Staudinger Reduction. Journal of the American Chemical Society. 143(44):18665-18671
Ye, Z., Kimelman, D. (2020) hox13 genes are required for mesoderm formation and axis elongation during early zebrafish development. Development (Cambridge, England). 147(22):
Bhadra, J., Pattanayak, S., Khan, P.P., Kundu, J., Sinha, S. (2016) Internal Oligoguanidinium-based Cellular Transporter Enhances Antisense Efficacy of Morpholinos in in vitro and Zebrafish model. Bioconjugate Chemistry. 27(10):2254-2259
Payumo, A.Y., Walker, W.J., McQuade, L.E., Yamazoe, S., Chen, J.K. (2015) Optochemical Dissection of T-box Gene-Dependent Medial Floor Plate Development. ACS Chemical Biology. 10(6):1466-75
Yamazoe, S., Liu, Q., McQuade, L.E., Deiters, A., Chen, J.K. (2014) Sequential Gene Silencing Using Wavelength-Selective Caged Morpholino Oligonucleotides. Angewandte Chemie (International ed. in English). 53(38):10114-8
Yamazoe, S., McQuade, L.E., Chen, J.K. (2014) Nitroreductase-Activatable Morpholino Oligonucleotides for in Vivo Gene Silencing. ACS Chemical Biology. 9(9):1985-90
Veerkamp, J., Rudolph, F., Cseresnyes, Z., Priller, F., Otten, C., Renz, M., Schaefer, L., and Abdelilah-Seyfried, S. (2013) Unilateral dampening of bmp activity by nodal generates cardiac left-right asymmetry. Developmental Cell. 24(6):660-667

1 - 10 of 19

Show