ZFIN Morpholino: MO2-ilk

Target Location

Genome Build: GRCz11Chromosome: 10

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO2-ilk

No data available

Phenotype

Phenotype resulting from MO2-ilk

Phenotype	Fish	Figures
cardiac ventricle decreased contractility, abnormal	WT + MO2-ilk	Fig. 3 from Bendig et al., 2006
heart contraction disrupted, abnormal	WT + MO2-ilk	Fig. 3 from Bendig et al., 2006
pericardium edematous, abnormal	WT + MO2-ilk	Fig. 3 from Bendig et al., 2006
post-vent region skeletal muscle cell retracted, abnormal	WT + MO2-ilk	text only from Postel et al., 2008
trunk musculature skeletal muscle cell retracted, abnormal	WT + MO2-ilk	text only from Postel et al., 2008

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Phenotype of all Fish created by or utilizing MO2-ilk

Phenotype	Fish	Conditions	Figures
heart contraction disrupted, abnormal	WT + MO2-ilk	standard conditions	Fig. 3 from Bendig et al., 2006
cardiac ventricle decreased contractility, abnormal	WT + MO2-ilk	standard conditions	Fig. 3 from Bendig et al., 2006
trunk musculature skeletal muscle cell retracted, abnormal	WT + MO2-ilk	standard conditions	text only from Postel et al., 2008
pericardium edematous, abnormal	WT + MO2-ilk	standard conditions	Fig. 3 from Bendig et al., 2006
post-vent region skeletal muscle cell retracted, abnormal	WT + MO2-ilk	standard conditions	text only from Postel et al., 2008

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Citations

Include unpublished citations

Kartopawiro, J., Bower, N.I., Karnezis, T., Kazenwadel, J., Betterman, K.L., Lesieur, E., Koltowska, K., Astin, J., Crosier, P., Vermeren, S., Achen, M.G., Stacker, S.A., Smith, K.A., Harvey, N.L., François, M., and Hogan, B.M. (2014) Arap3 is dysregulated in a mouse model of hypotrichosis-lymphedema-telangiectasia and regulates lymphatic vascular development. Human molecular genetics. 23(5):1286-97
Postel, R., Margadant, C., Fischer, B., Kreft, M., Janssen, H., Secades, P., Zambruno, G., and Sonnenberg, A. (2013) Kindlin-1 mutant zebrafish as an in vivo model sytem to study adhesion mechanisms in the epidermis. The Journal of investigative dermatology. 133(9):2180-90
Vogel, B., Meder, B., Just, S., Laufer, C., Berger, I., Weber, S., Katus, H.A., and Rottbauer, W. (2009) In-vivo Characterization of Human Dilated Cardiomyopathy Genes in Zebrafish. Biochemical and Biophysical Research Communications. 390(3):516-522
Postel, R., Vakeel, P., Topczewski, J., Knöll, R., and Bakkers, J. (2008) Zebrafish integrin-linked kinase is required in skeletal muscles for strengthening the integrin-ECM adhesion complex. Developmental Biology. 318(1):92-101
Bendig, G., Grimmler, M., Huttner, I.G., Wessels, G., Dahme, T., Just, S., Trano, N., Katus, H.A., Fishman, M.C., and Rottbauer, W. (2006) Integrin-linked kinase, a novel component of the cardiac mechanical stretch sensor, controls contractility in the zebrafish heart. Genes & Development. 20(17):2361-2372

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