ZFIN Morpholino: MO1-ndr2

Target Location

Genome Build: GRCz11Chromosome: 12

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-ndr2

No data available

Phenotype

Phenotype resulting from MO1-ndr2

Phenotype	Fish	Figures
camera-type eye morphogenesis disrupted, abnormal	AB + MO1-ndr2	Fig. 4 from England et al., 2006
forebrain morphogenesis disrupted, abnormal	AB + MO1-ndr2	Fig. 3 from England et al., 2006

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Phenotype of all Fish created by or utilizing MO1-ndr2

Phenotype	Fish	Conditions	Figures
camera-type eye morphogenesis disrupted, abnormal	AB + MO1-ndr2	standard conditions	Fig. 4 from England et al., 2006
forebrain morphogenesis disrupted, abnormal	AB + MO1-ndr2	standard conditions	Fig. 3 from England et al., 2006
endoderm formation decreased occurrence, abnormal	WT + MO1-ndr2 + MO4-ndr1	standard conditions	Fig. 3 from Pelliccia et al., 2017
notochord decreased thickness, abnormal	WT + MO1-ndr2 + MO4-ndr1	standard conditions	Fig. 5 from Fan et al., 2007
mesoderm formation decreased occurrence, abnormal	WT + MO1-ndr2 + MO4-ndr1	standard conditions	Fig. 3 from Pelliccia et al., 2017

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Citations

Include unpublished citations

Kurup, A.J., Bailet, F., Fürthauer, M. (2024) Myosin1G promotes Nodal signaling to control zebrafish left-right asymmetry. Nature communications. 15:65476547
Schauer, A., Pinheiro, D., Hauschild, R., Heisenberg, C.P. (2020) Zebrafish embryonic explants undergo genetically encoded self-assembly. eLIFE. 9:
Liu, Z., Woo, S., Weiner, O.D. (2018) Nodal signaling has dual roles in fate specification and directed migration during germ layer segregation. Development (Cambridge, England). 145(17):
Pelliccia, J.L., Jindal, G.A., Burdine, R.D. (2017) Gdf3 is required for robust Nodal signaling during germ layer formation and left-right patterning. eLIFE. 6
Dubrulle, J., Jordan, B.M., Akhmetova, L., Farrell, J.A., Kim, S.H., Solnica-Krezel, L., Schier, A.F. (2015) Response to Nodal morphogen gradient is determined by the kinetics of target gene induction. eLIFE. 4
Chen, Y.Y., Harris, M.P., Levesque, M.P., Nüsslein-Volhard, C., and Sonawane, M. (2012) Heterogeneity across the dorso-ventral axis in zebrafish EVL is regulated by a novel module consisting of sox, snail1a and max genes. Mechanisms of Development. 129(1-4):13-23
Hong, S.K., Jang, M.K., Brown, J.L., McBride, A.A., and Feldman, B. (2011) Embryonic mesoderm and endoderm induction requires the actions of non-embryonic Nodal-related ligands and Mxtx2. Development (Cambridge, England). 138(4):787-795
Slagle, C.E., Aoki, T., and Burdine, R.D. (2011) Nodal-Dependent Mesendoderm Specification Requires the Combinatorial Activities of FoxH1 and Eomesodermin. PLoS Genetics. 7(5):e1002072
Varga, M., Maegawa, S., and Weinberg, E.S. (2011) Correct anteroposterior patterning of the zebrafish neurectoderm in the absence of the early dorsal organizer. BMC Developmental Biology. 11(1):26
Mangos, S., Lam, P.Y., Zhao, A., Liu, Y., Mudumana, S., Vasilyev, A., Liu, A., and Drummond, I.A. (2010) The ADPKD genes pkd1a/b and pkd2 regulate extracellular matrix formation. Disease models & mechanisms. 3(5-6):354-365

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