ZFIN Morpholino: MO1-ilk

Target Location

Genome Build: GRCz11Chromosome: 10

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-ilk

No data available

Phenotype

Phenotype resulting from MO1-ilk

Phenotype	Fish	Figures
blood circulation disrupted, abnormal	WT + MO1-ilk	Fig. 2 from Vogel et al., 2009
cardiac ventricle decreased contractility, abnormal	WT + MO1-ilk	Fig. 3 from Bendig et al., 2006
heart decreased contractility, abnormal	WT + MO1-ilk	Fig. 2 from Vogel et al., 2009
heart contraction disrupted, abnormal	WT + MO1-ilk	Fig. 3 from Bendig et al., 2006
pericardium edematous, abnormal	WT + MO1-ilk	Fig. 4 from Chang et al., 2019 Fig. 8 from Yuan et al., 2015 Fig. 2 from Vogel et al., 2009 Fig. 3 from Bendig et al., 2006

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Phenotype of all Fish created by or utilizing MO1-ilk

Phenotype	Fish	Conditions	Figures
heart contraction disrupted, abnormal	WT + MO1-ilk	standard conditions	Fig. 3 from Bendig et al., 2006
sinus venosus increased accumulation blood, abnormal	WT + MO1-ilk	standard conditions	Fig. 2 from Vogel et al., 2009
blood circulation disrupted, abnormal	WT + MO1-ilk	standard conditions	Fig. 2 from Vogel et al., 2009
heart decreased contractility, abnormal	WT + MO1-ilk	standard conditions	Fig. 2 from Vogel et al., 2009
pericardium edematous, abnormal	WT + MO1-ilk	standard conditions	Fig. 4 from Chang et al., 2019 Fig. 8 from Yuan et al., 2015 Fig. 2 from Vogel et al., 2009 Fig. 3 from Bendig et al., 2006

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Citations

Include unpublished citations

Müller, M., Eghbalian, R., Boeckel, J.N., Frese, K.S., Haas, J., Kayvanpour, E., Sedaghat-Hamedani, F., Lackner, M.K., Tugrul, O.F., Ruppert, T., Tappu, R., Martins Bordalo, D., Kneuer, J.M., Piekarek, A., Herch, S., Schudy, S., Keller, A., Grammes, N., Bischof, C., Klinke, A., Cardoso-Moreira, M., Kaessmann, H., Katus, H.A., Frey, N., Steinmetz, L.M., Meder, B. (2022) NIMA-related kinase 9 regulates the phosphorylation of the essential myosin light chain in the heart. Nature communications. 13:6209
Chang, Y., Geng, F., Hu, Y., Ding, Y., Zhang, R. (2019) Zebrafish cysteine and glycine-rich protein 3 is essential for mechanical stability in skeletal muscles. Biochemical and Biophysical Research Communications. 511(3):604-611
Yuan, J.M., He, B.L., Yang, L.Y., Guo, C.J., Weng, S.P., Li, S.C., He, J.G. (2015) Interaction of Infectious Spleen and Kidney Necrosis Virus ORF119L with PINCH Leads to Dominant-Negative Inhibition of ILK and Cardiovascular Defects in Zebrafish. Journal of virology. 89(1):763-75
Kartopawiro, J., Bower, N.I., Karnezis, T., Kazenwadel, J., Betterman, K.L., Lesieur, E., Koltowska, K., Astin, J., Crosier, P., Vermeren, S., Achen, M.G., Stacker, S.A., Smith, K.A., Harvey, N.L., François, M., and Hogan, B.M. (2014) Arap3 is dysregulated in a mouse model of hypotrichosis-lymphedema-telangiectasia and regulates lymphatic vascular development. Human molecular genetics. 23(5):1286-97
Vogel, B., Meder, B., Just, S., Laufer, C., Berger, I., Weber, S., Katus, H.A., and Rottbauer, W. (2009) In-vivo Characterization of Human Dilated Cardiomyopathy Genes in Zebrafish. Biochemical and Biophysical Research Communications. 390(3):516-522
Zhang, R., Yang, J., Zhu, J., and Xu, X. (2009) Depletion of zebrafish Tcap leads to muscular dystrophy via disrupting sarcomere-membrane interaction, not sarcomere assembly. Human molecular genetics. 18(21):4130-4140
Bendig, G., Grimmler, M., Huttner, I.G., Wessels, G., Dahme, T., Just, S., Trano, N., Katus, H.A., Fishman, M.C., and Rottbauer, W. (2006) Integrin-linked kinase, a novel component of the cardiac mechanical stretch sensor, controls contractility in the zebrafish heart. Genes & Development. 20(17):2361-2372

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