ZFIN Morpholino: MO1-lef1

Target Location

Genome Build: GRCz11Chromosome: 1

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-lef1

No data available

Phenotype

Phenotype resulting from MO1-lef1

Phenotype	Fish	Figures
cartilage morphogenesis disrupted, abnormal	WT + MO1-lef1	Fig. 1 from Ishitani et al., 2005
caudal fin morphology, abnormal	WT + MO1-lef1	Fig. 1 from Ishitani et al., 2005
cranial cartilage morphology, abnormal	WT + MO1-lef1	Fig. 1 from Ishitani et al., 2005
dorsal root ganglion decreased amount, abnormal	WT + MO1-lef1	Fig. 1 from Ishitani et al., 2005
dorsal root ganglion mislocalised, abnormal	WT + MO1-lef1	Fig. 1 from Ishitani et al., 2005

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Phenotype of all Fish created by or utilizing MO1-lef1

Phenotype	Fish	Conditions	Figures
melanocyte decreased amount, abnormal	WT + MO1-lef1	standard conditions	Fig. 3 from Ishitani et al., 2005
caudal fin morphology, abnormal	WT + MO1-lef1	standard conditions	Fig. 1 from Ishitani et al., 2005
cartilage morphogenesis disrupted, abnormal	WT + MO1-lef1	standard conditions	Fig. 1 from Ishitani et al., 2005
neural crest cell development disrupted, abnormal	WT + MO1-lef1	standard conditions	Fig. 1 from Ishitani et al., 2005
post-vent region decreased length, abnormal	WT + MO1-lef1	standard conditions	Fig. 2 from Dorsky et al., 2002

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Citations

Include unpublished citations

Hübner, K., Grassme, K.S., Rao, J., Wenke, N.K., Zimmer, C.L., Korte, L., Mu Ller, K., Sumanas, S., Greber, B., Herzog, W. (2017) Wnt Signaling Positively Regulates Endothelial Cell Fate Specification in the Fli1a-Positive Progenitor Population via Lef1. Developmental Biology. 430(1):142-155
Nicenboim, J., Malkinson, G., Lupo, T., Asaf, L., Sela, Y., Mayseless, O., Gibbs-Bar, L., Senderovich, N., Hashimshony, T., Shin, M., Jerafi-Vider, A., Avraham-Davidi, I., Krupalnik, V., Hofi, R., Almog, G., Astin, J.W., Golani, O., Ben-Dor, S., Crosier, P.S., Herzog, W., Lawson, N.D., Hanna, J.H., Yanai, I., Yaniv, K. (2015) Lymphatic vessels arise from specialized angioblasts within a venous niche. Nature. 522(7554):56-61
Ota, S., Ishitani, S., Shimizu, N., Matsumoto, K., Itoh, M., and Ishitani, T. (2012) NLK positively regulates Wnt/beta-catenin signalling by phosphorylating LEF1 in neural progenitor cells. The EMBO journal. 31(8):1904-1915
Shimizu, N., Kawakami, K., and Ishitani, T. (2012) Visualization and exploration of Tcf/Lef function using a highly responsive Wnt/beta-catenin signaling-reporter transgenic zebrafish. Developmental Biology. 370(1):71-85
Gamba, L., Cubedo, N., Lutfalla, G., Ghysen, A., and Dambly-Chaudiere, C. (2010) Lef1 controls patterning and proliferation in the posterior lateral line system of zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 239(12):3163-3171
Paridaen, J.T., Danesin, C., Elas, A.T., van de Water, S., Houart, C., and Zivkovic, D. (2009) Apc1 is required for maintenance of local brain organizers and dorsal midbrain survival. Developmental Biology. 331(2):101-112
Tee, J.M., van Rooijen, C., Boonen, R., and Zivkovic, D. (2009) Regulation of slow and fast muscle myofibrillogenesis by Wnt/beta-catenin and myostatin signaling. PLoS One. 4(6):e5880
Thatcher, E.J., Paydar, I., Anderson, K.K., and Patton, J.G. (2008) Regulation of zebrafish fin regeneration by microRNAs. Proceedings of the National Academy of Sciences of the United States of America. 105(47):18384-18389
Ishitani, T., Matsumoto, K., Chitnis, A.B., and Itoh, M. (2005) Nrarp functions to modulate neural-crest-cell differentiation by regulating LEF1 protein stability. Nature cell biology. 7(11):1106-1112
Thorpe, C.J., and Moon, R.T. (2004) nemo-like kinase is an essential co-activator of Wnt signaling during early zebrafish development. Development (Cambridge, England). 131(12):2899-2909

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