ZFIN Morpholino: MO1-ripply1

Target Location

Genome Build: GRCz11Chromosome: 21

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-ripply1

No data available

Phenotype

Phenotype resulting from MO1-ripply1

Phenotype	Fish	Figures
dermomyotome increased amount, abnormal	WT + MO1-ripply1 + MO4-tp53	Fig. 5 from Windner et al., 2015
fast muscle cell skeletal muscle tissue development decreased occurrence, abnormal	i106Tg + MO1-ripply1	Fig. 7 from Yin et al., 2018
paraxial mesoderm tbx6 expression increased amount, abnormal	WT + MO1-ripply1 + MO4-tp53	Fig. 4 from Windner et al., 2015
paraxial mesoderm tbx6 expression increased distribution, abnormal	WT + MO1-ripply1 + MO4-tp53	Fig. 4 from Windner et al., 2015
segment polarity determination disrupted, abnormal	TL + MO1-ripply1	Fig. 4 from Kawamura et al., 2005

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Phenotype of all Fish created by or utilizing MO1-ripply1

Phenotype	Fish	Conditions	Figures
segment polarity determination disrupted, abnormal	TL + MO1-ripply1	standard conditions	Fig. 4 from Kawamura et al., 2005
somite border absent, abnormal	TL + MO1-ripply1	standard conditions	Fig. 3 from Kawamura et al., 2005
somitogenesis disrupted, abnormal	TL + MO1-ripply1	standard conditions	Fig. 3, Fig. 4 from Kawamura et al., 2005
trunk posterior region tbx6 expression increased distribution, abnormal	WT + MO1-ripply1 + MO4-tp53	control	Fig. 5 from Windner et al., 2015
trunk posterior region tbx6 expression mislocalised, abnormal	WT + MO1-ripply1 + MO4-tp53	control	Fig. 5 from Windner et al., 2015

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Citations

Include unpublished citations

Yabe, T., Uriu, K., Takada, S. (2023) Ripply suppresses Tbx6 to induce dynamic-to-static conversion in somite segmentation. Nature communications. 14:21152115
Yin, J., Lee, R., Ono, Y., Ingham, P.W., Saunders, T.E. (2018) Spatiotemporal Coordination of FGF and Shh Signaling Underlies the Specification of Myoblasts in the Zebrafish Embryo. Developmental Cell. 46:735-750.e4
Windner, S.E., Doris, R.A., Ferguson, C.M., Nelson, A.C., Valentin, G., Tan, H., Oates, A.C., Wardle, F.C., Devoto, S.H. (2015) Tbx6, Mesp-b and Ripply1 regulate the onset of skeletal myogenesis in zebrafish. Development (Cambridge, England). 142(6):1159-68
Retnoaji, B., Akiyama, R., Matta, T., Bessho, Y., and Matsui, T. (2014) Retinoic acid controls proper head-to-trunk linkage in zebrafish by regulating an anteroposterior somitogenetic rate difference. Development (Cambridge, England). 141(1):158-165
Wanglar, C., Takahashi, J., Yabe, T., Takada, S. (2014) Tbx Protein Level Critical for Clock-Mediated Somite Positioning Is Regulated through Interaction between Tbx and Ripply. PLoS One. 9:e107928
Kawamura, A., Koshida, S., and Takada, S. (2008) Activator-to-repressor conversion of T-box transcription factors by the Ripply family of Groucho/TLE-associated mediators. Molecular and cellular biology. 28(10):3236-3244
Moreno, T.A., Jappelli, R., Izpisúa Belmonte, J.C., and Kintner, C. (2008) Retinoic acid regulation of the Mesp-Ripply feedback loop during vertebrate segmental patterning. Developmental Biology. 315(2):317-330
Kawamura, A., Koshida, S., Hijikata, H., Ohbayashi, A., Kondoh, H., and Takada, S. (2005) Groucho-associated transcriptional repressor ripply1 is required for proper transition from the presomitic mesoderm to somites. Developmental Cell. 9(6):735-744

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