ZFIN Morpholino: MO3-tp53

Target Location

Genome Build: GRCz11Chromosome: 5

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO3-tp53

No data available

Phenotype

Phenotype resulting from MO3-tp53

No data available

Phenotype of all Fish created by or utilizing MO3-tp53

Phenotype	Fish	Conditions	Figures
otolith decreased amount, abnormal	WT + MO1-tectb + MO3-tp53	standard conditions	Fig. 4 from Yang et al., 2011
otolith fused with otolith, abnormal	WT + MO1-tectb + MO3-tp53	standard conditions	Fig. 4 from Yang et al., 2011
otolith development disrupted, abnormal	WT + MO1-tectb + MO3-tp53	standard conditions	Fig. 4 from Yang et al., 2011
whole organism anterior-posterior axis curved, abnormal	WT + MO1-znf219 + MO3-tp53	standard conditions	Fig. 3 from Lien et al., 2013
notochord curved, abnormal	WT + MO1-znf219 + MO3-tp53	standard conditions	Fig. 3 from Lien et al., 2013

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Citations

Include unpublished citations

Lin, C.Y., Tsai, M.Y., Liu, Y.H., Lu, Y.F., Chen, Y.C., Lai, Y.R., Liao, H.C., Lien, H.W., Yang, C.H., Huang, C.J., Hwang, S.L. (2017) Klf8 regulates left-right asymmetric patterning through modulation of Kupffer's vesicle morphogenesis and spaw expression. Journal of Biomedical Science. 24:45
Tsai, M., Lu, Y., Liu, Y., Lien, H., Huang, C., Wu, J., Hwang, S.L. (2015) Modulation of p53 and met expression by krüppel-like factor 8 regulates zebrafish cerebellar development. Developmental Neurobiology. 75(9):908-26
Lien, H.W., Yang, C.H., Cheng, C.H., Hung, C.C., Liao, W.H., Hwang, P.P., Han, Y.S., and Huang, C.J. (2013) A Novel Zinc Finger Protein 219-like (ZNF219L) is Involved in the Regulation of Collagen Type 2 Alpha 1a (col2a1a) Gene Expression in Zebrafish Notochord. International journal of biological sciences. 9(9):872-886
Provost, E., Wehner, K.A., Zhong, X., Ashar, F., Nguyen, E., Green, R., Parsons, M.J., and Leach, S.D. (2012) Ribosomal biogenesis genes play an essential and p53-independent role in zebrafish pancreas development. Development (Cambridge, England). 139(17):3232-3241
Yang, C.H., Cheng, C.H., Chen, G.D., Liao, W.H., Chen, Y.C., Huang, K.Y., Hwang, P.P., Hwang, S.P., and Huang, C.J. (2011) Zona Pellucida Domain-Containing Protein β-Tectorin is Crucial for Zebrafish Proper Inner Ear Development. PLoS One. 6(8):e23078
Davuluri, G., Gong, W., Yusuff, S., Lorent, K., Muthumani, M., Dolan, A.C., and Pack, M. (2008) Mutation of the zebrafish nucleoporin elys sensitizes tissue progenitors to replication stress. PLoS Genetics. 4(10):e1000240
Skarie, J.M., and Link, B.A. (2008) The Primary open-angle glaucoma gene WDR36 functions in ribosomal RNA processing and interacts with the p53 stress–response pathway. Human molecular genetics. 17(16):2474-2485
Chen, J., Ruan, H., Ng, S.M., Gao, C., Soo, H.M., Wu, W., Zhang, Z., Wen, Z., Lane, D.P., and Peng, J. (2005) Loss of function of def selectively up-regulates {Delta}113p53 expression to arrest expansion growth of digestive organs in zebrafish. Genes & Development. 19(23):2900-2911

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