ZFIN Morpholino: MO1-sox10

Target Location

Genome Build: GRCz11Chromosome: 3

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-sox10

No data available

Phenotype

Phenotype resulting from MO1-sox10

Phenotype	Fish	Figures
anterior crista physical object quality, abnormal	as11Tg + MO1-sox10	Fig. 10 from Tang et al., 2014
ceratobranchial cartilage absent, abnormal	ba2Tg + MO1-sox10	Fig. 7 from Asad et al., 2016
developmental growth decreased rate, abnormal	WT + MO1-sox10	Fig. 6 from Kamei et al., 2018
hematopoietic multipotent progenitor cell runx1 expression decreased amount, abnormal	WIK + MO1-sox10	Fig. 5 from Damm et al., 2017
hematopoietic multipotent progenitor cell decreased amount, abnormal	WIK + MO1-sox10	Fig. 5 from Damm et al., 2017

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Phenotype of all Fish created by or utilizing MO1-sox10

Phenotype	Fish	Conditions	Figures
pharyngeal arch chondrocyte sox9a expression decreased amount, abnormal	TU + MO1-sox10	standard conditions	Fig. 7 from Asad et al., 2016
myelinating Schwann cell myelination disrupted, abnormal	TU + MO1-sox10	standard conditions	Fig. 6 from Asad et al., 2016
myelinating Schwann cell mbpa expression decreased amount, abnormal	TU + MO1-sox10	standard conditions	Fig. 6 from Asad et al., 2016
myelinating Schwann cell mbpa expression decreased distribution, abnormal	TU + MO1-sox10	standard conditions	Fig. 6 from Asad et al., 2016
melanocyte dct expression decreased amount, abnormal	TU + MO1-sox10	standard conditions	Fig. 4 from Asad et al., 2016

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Citations

Include unpublished citations

Takamiya, M., Stegmaier, J., Kobitski, A.Y., Schott, B., Weger, B.D., Margariti, D., Cereceda Delgado, A.R., Gourain, V., Scherr, T., Yang, L., Sorge, S., Otte, J.C., Hartmann, V., van Wezel, J., Stotzka, R., Reinhard, T., Schlunck, G., Dickmeis, T., Rastegar, S., Mikut, R., Nienhaus, G.U., Strähle, U. (2020) Pax6 organizes the anterior eye segment by guiding two distinct neural crest waves. PLoS Genetics. 16:e1008774
Staudt, N., Giger, F.A., Fielding, T., Hutt, J.A., Foucher, I., Snowden, V., Hellich, A., Kiecker, C., Houart, C. (2019) Pineal progenitors originate from a non-neural territory limited by FGF signalling. Development (Cambridge, England). 146(22):
Kamei, H., Yoneyama, Y., Hakuno, F., Sawada, R., Shimizu, T., Duan, C., Takahashi, S.I. (2018) Catch-up growth in zebrafish embryo requires neural crest cells sustained by Irs1-signaling. Endocrinology. 159(4):1547-1560
Damm, E.W., Clements, W.K. (2017) Pdgf signalling guides neural crest contribution to the haematopoietic stem cell specification niche. Nature cell biology. 19(5):457-467
Asad, Z., Pandey, A., Babu, A., Sun, Y., Shevade, K., Kapoor, S., Ullah, I., Ranjan, S., Scaria, V., Bajpai, R., Sachidanandan, C. (2016) Rescue of neural crest derived phenotypes in a zebrafish CHARGE model by sox10 downregulation. Human molecular genetics. 25(16):3539-3554
Tang, C.H., Lai, Y.R., Chen, Y.C., Li, C.H., Lu, Y.F., Chen, H.Y., Lien, H.W., Yang, C.H., Huang, C.J., Wang, C.Y., Kao, C.F., Hwang, S.P. (2014) Expression of zebrafish anterior gradient 2 in the semicircular canals and supporting cells of otic vesicle sensory patches is regulated by Sox10. Biochimica et biophysica acta. Gene regulatory mechanisms. 1839(6):425-37
Saxena, A., Peng, B.N., and Bronner, M.E. (2013) Sox10-dependent neural crest origin of olfactory microvillous neurons in zebrafish. eLIFE. 2:e00336
Drerup, C.M., Wiora, H.M., Topczewski, J., and Morris, J.A. (2009) Disc1 regulates foxd3 and sox10 expression, affecting neural crest migration and differentiation. Development (Cambridge, England). 136(15):2623-2632
Whitlock, K.E., Smith, K.M., Kim, H., and Harden, M.V. (2005) A role for foxd3 and sox10 in the differentiation of gonadotropin-releasing hormone (GnRH) cells in the zebrafish Danio rerio. Development (Cambridge, England). 132(24):5491-5502

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