ZFIN Morpholino: MO1-cxcl12b

Target Location

Genome Build: GRCz11Chromosome: 22

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-cxcl12b

No data available

Phenotype

Phenotype resulting from MO1-cxcl12b

Phenotype	Fish	Figures
axon guidance process quality, abnormal	WT + MO1-cxcl12b	Fig. S4 from Hollway et al., 2007
cell migration involved in gastrulation delayed, abnormal	ha01Tg + MO1-cxcl12b	Fig. S2 from Mizoguchi et al., 2008
endodermal cell displaced to margin, abnormal	WT + MO1-cxcl12b	Fig. 1 from Nair et al., 2008
endodermal cell mislocalised anteriorly, abnormal	WT + MO1-cxcl12b	Fig. 1 from Nair et al., 2008
intestine duplicated, abnormal	WT + MO1-cxcl12b	Fig. 1 from Nair et al., 2008

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Phenotype of all Fish created by or utilizing MO1-cxcl12b

Phenotype	Fish	Conditions	Figures
endodermal cell mislocalised anteriorly, abnormal	WT + MO1-cxcl12b	standard conditions	Fig. 1 from Nair et al., 2008
trigeminal ganglion axon position, abnormal	WT + MO1-cxcl12b	standard conditions	Fig. S4 from Hollway et al., 2007
intestine duplicated, abnormal	WT + MO1-cxcl12b	standard conditions	Fig. 1 from Nair et al., 2008
somite cellular quality, abnormal	WT + MO1-cxcl12b	standard conditions	Fig. 6 from Hollway et al., 2007
axon guidance process quality, abnormal	WT + MO1-cxcl12b	standard conditions	Fig. S4 from Hollway et al., 2007

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Citations

Include unpublished citations

Wei, Z., Hong, Q., Ding, Z., Liu, J. (2023) cxcl12a plays an essential role in pharyngeal cartilage development. Frontiers in cell and developmental biology. 11:12432651243265
Jiang, D., Jiang, Z., Lu, D., Wang, X., Liang, H., Zhang, J., Meng, Y., Li, Y., Wu, D., Huang, Y., Chen, Y., Deng, H., Wu, Q., Xiong, J., Meng, A., Yu, L. (2019) Migrasomes provide regional cues for organ morphogenesis during zebrafish gastrulation. Nature cell biology. 21:966-977
Nguyen, P.D., Hollway, G.E., Sonntag, C., Miles, L.B., Hall, T.E., Berger, S., Fernandez, K.J., Gurevich, D.B., Cole, N.J., Alaei, S., Ramialison, M., Sutherland, R.L., Polo, J.M., Lieschke, G.J., Currie, P.D. (2014) Haematopoietic stem cell induction by somite-derived endothelial cells controlled by meox1. Nature. 512(7514):314-8
Lewellis, S.W., Nagelberg, D., Subedi, A., Staton, A., Leblanc, M., Giraldez, A., and Knaut, H. (2013) Precise SDF1-mediated cell guidance is achieved through ligand clearance and microRNA-mediated decay. The Journal of cell biology. 200(3):337-355
Cha, Y.R., Fujita, M., Butler, M., Isogai, S., Kochhan, E., Siekmann, A.F., and Weinstein, B.M. (2012) Chemokine Signaling Directs Trunk Lymphatic Network Formation along the Preexisting Blood Vasculature. Developmental Cell. 22(4):824-836
Boldajipour, B., Doitsidou, M., Tarbashevich, K., Laguri, C., Yu, S.R., Ries, J., Dumstrei, K., Thelen, S., Dörries, J., Messerschmidt, E.M., Thelen, M., Schwille, P., Brand, M., Lortat-Jacob, H., and Raz, E. (2011) Cxcl12 evolution - subfunctionalization of a ligand through altered interaction with the chemokine receptor. Development (Cambridge, England). 138(14):2909-2914
Fujita, M., Cha, Y.R., Pham, V.N., Sakurai, A., Roman, B.L., Gutkind, J.S., and Weinstein, B.M. (2011) Assembly and patterning of the vascular network of the vertebrate hindbrain. Development (Cambridge, England). 138(9):1705-1715
Palevitch, O., Abraham, E., Borodovsky, N., Levkowitz, G., Zohar, Y., and Gothilf, Y. (2010) Cxcl12a-Cxcr4b signaling is important for proper development of the forebrain GnRH system in zebrafish. General and comparative endocrinology. 165(2):262-268
Walters, K.B., Green, J.M., Surfus, J.C., Yoo, S.K., and Huttenlocher, A. (2010) Live imaging of neutrophil motility in a zebrafish model of WHIM syndrome. Blood. 116(15):2803-2811
Olesnicky Killian, E.C., Birkholz, D.A., and Artinger, K.B. (2009) A role for chemokine signaling in neural crest cell migration and craniofacial development. Developmental Biology. 333(1):161-172

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