ZFIN Morpholino: MO1-flt1

Target Location

Genome Build: GRCz11Chromosome: 24

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-flt1

No data available

Phenotype

Phenotype resulting from MO1-flt1

Phenotype	Fish	Figures
cardiac ventricle decreased contractility, abnormal	WT + MO1-flt1	Fig. 5 from Rottbauer et al., 2005
cardiac ventricle non-contractile, abnormal	WT + MO1-flt1	Fig. 5 from Rottbauer et al., 2005
interconnecting vessels decreased length, abnormal	y1Tg + MO1-flt1	Fig. 7 from Hen et al., 2015
pericardium edematous, abnormal	WT + MO1-flt1	Fig. 5 from Rottbauer et al., 2005
subintestinal vein has extra parts of type vascular sprouts, abnormal	y1Tg + MO1-flt1	Fig. 7 from Hen et al., 2015

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Phenotype of all Fish created by or utilizing MO1-flt1

Phenotype	Fish	Conditions	Figures
cardiac ventricle non-contractile, abnormal	WT + MO1-flt1	standard conditions	Fig. 5 from Rottbauer et al., 2005
cardiac ventricle decreased contractility, abnormal	WT + MO1-flt1	standard conditions	Fig. 5 from Rottbauer et al., 2005
pericardium edematous, abnormal	WT + MO1-flt1	standard conditions	Fig. 5 from Rottbauer et al., 2005
subintestinal vein has extra parts of type vascular sprouts, abnormal	y1Tg + MO1-flt1	standard conditions	Fig. 7 from Hen et al., 2015
interconnecting vessels decreased length, abnormal	y1Tg + MO1-flt1	standard conditions	Fig. 7 from Hen et al., 2015

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Citations

Include unpublished citations

Hen, G., Nicenboim, J., Mayseless, O., Asaf, L., Shin, M., Busolin, G., Hofi, R., Almog, G., Tiso, N., Lawson, N.D., Yaniv, K. (2015) Venous-derived angioblasts generate organ-specific vessels during embryonic development. Development (Cambridge, England). 142(24):4266-78
Ba, Q., Duan, J., Tian, J.Q., Wang, Z.L., Chen, T., Li, X.G., Chen, P.Z., Wu, S.J., Xiang, L., Li, J.Q., Chu, R.A., and Wang, H. (2013) Dihydroartemisinin promotes angiogenesis during the early embryonic development of zebrafish. Acta Pharmacologica Sinica. 34(8):1101-7
Hassel, D., Cheng, P., White, M.P., Ivey, K.N., Kroll, J., Augustin, H.G., Katus, H.A., Stainier, D.Y., and Srivastava, D. (2012) MicroRNA-10 Regulates the Angiogenic Behavior of Zebrafish and Human Endothelial Cells by Promoting Vascular Endothelial Growth Factor Signaling. Circulation research. 111(11):1421-1433
Zygmunt, T., Gay, C.M., Blondelle, J., Singh, M.K., Flaherty, K.M., Means, P.C., Herwig, L., Krudewig, A., Belting, H.G., Affolter, M., Epstein, J.A., and Torres-Vazquez, J. (2011) Semaphorin-PlexinD1 Signaling Limits Angiogenic Potential via the VEGF Decoy Receptor sFlt1. Developmental Cell. 21(2):301-314
Rottbauer, W., Just, S., Wessels, G., Trano, N., Most, P., Katus, H.A., and Fishman, M.C. (2005) VEGF-PLC{gamma}1 pathway controls cardiac contractility in the embryonic heart. Genes & Development. 19(13):1624-1634

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