ZFIN Morpholino: MO1-lmx1ba

Target Location

Genome Build: GRCz11Chromosome: 5

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-lmx1ba

No data available

Phenotype

Phenotype resulting from MO1-lmx1ba

Phenotype	Fish	Figures
fourth ventricle structure, abnormal	AB + MO1-lmx1ba	Fig. 5 from Elsen et al., 2008
fourth ventricle development disrupted, abnormal	AB + MO1-lmx1ba	Fig. 5 from Elsen et al., 2008
heart edematous, abnormal	ki1Tg + MO1-lmx1ba	Fig. 3 from He et al., 2014
pronephric glomerulus physical object quality, abnormal	ki1Tg + MO1-lmx1ba	Fig. 3 from He et al., 2014

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Phenotype of all Fish created by or utilizing MO1-lmx1ba

Phenotype	Fish	Conditions	Figures
fourth ventricle development disrupted, abnormal	AB + MO1-lmx1ba	standard conditions	Fig. 5 from Elsen et al., 2008
fourth ventricle structure, abnormal	AB + MO1-lmx1ba	standard conditions	Fig. 5 from Elsen et al., 2008
pronephric glomerulus physical object quality, abnormal	ki1Tg + MO1-lmx1ba	standard conditions	Fig. 3 from He et al., 2014
heart edematous, abnormal	ki1Tg + MO1-lmx1ba	standard conditions	Fig. 3 from He et al., 2014
cerebellum aplastic, abnormal	TL + MO1-lmx1ba + MO1-lmx1bb	standard conditions	Fig. 4 from O'Hara et al., 2005

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Citations

Include unpublished citations

He, B., Ebarasi, L., Zhao, Z., Guo, J., Ojala, J.R., Hultenby, K., De Val, S., Betsholtz, C., Tryggvason, K. (2014) Lmx1b and FoxC Combinatorially Regulate Podocin Expression in Podocytes. Journal of the American Society of Nephrology : JASN. 25(12):2764-77
Burghardt, T., Kastner, J., Suleiman, H., Rivera-Milla, E., Stepanova, N., Lottaz, C., Kubitza, M., Böger, C.A., Schmidt, S., Gorski, M., de Vries, U., Schmidt, H., Hertting, I., Kopp, J., Rascle, A., Moser, M., Heid, I.M., Warth, R., Spang, R., Wegener, J., Mierke, C.T., Englert, C., and Witzgall, R. (2013) LMX1B is Essential for the Maintenance of Differentiated Podocytes in Adult Kidneys. Journal of the American Society of Nephrology : JASN. 24(11):1830-48
Katherine, B.V., Roger, L.B., and Rodríguez, R.E. (2013) Cocaine modulates the expression of transcription factors related to the dopaminergic system in zebrafish. Neuroscience. 231:258-271
Elsen, G.E., Choi, L.Y., Millen, K.J., Grinblat, Y., and Prince, V.E. (2008) Zic1 and Zic4 regulate zebrafish roof plate specification and hindbrain ventricle morphogenesis. Developmental Biology. 314(2):376-392
Filippi, A., Duerr, K., Ryu, S., Willaredt, M., Holzschuh, J., and Driever, W. (2007) Expression and function of nr4a2, lmx1b, and pitx3 in zebrafish dopaminergic and noradrenergic neuronal development. BMC Developmental Biology. 7(1):135
O'Hara, F.P., Beck, E., Barr, L.K., Wong, L.L., Kessler, D.S., and Riddle, R.D. (2005) Zebrafish Lmx1b.1 and Lmx1b.2 are required for maintenance of the isthmic organizer. Development (Cambridge, England). 132(14):3163-3173

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