ZFIN Morpholino: MO1-lmx1bb

Target Location

Genome Build: GRCz11Chromosome: 8

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-lmx1bb

No data available

Phenotype

Phenotype resulting from MO1-lmx1bb

Phenotype	Fish	Figures
heart edematous, abnormal	ki1Tg + MO1-lmx1bb	Fig. 3 from He et al., 2014
optokinetic behavior decreased occurrence, abnormal	AB + MO1-lmx1bb	Fig. 6 from Wang et al., 2019
optokinetic behavior decreased process quality, abnormal	AB + MO1-lmx1bb	Fig. 6 from Wang et al., 2019
podocyte development decreased process quality, abnormal	AB + MO1-lmx1bb	Fig. 4 from He et al., 2014
pronephric glomerular capillary increased diameter, abnormal	AB + MO1-lmx1bb	Fig. 4 from He et al., 2014

1 - 5 of 8 Show all

Phenotype of all Fish created by or utilizing MO1-lmx1bb

Phenotype	Fish	Conditions	Figures
podocyte development decreased process quality, abnormal	AB + MO1-lmx1bb	standard conditions	Fig. 4 from He et al., 2014
pronephric glomerulus lacks all parts of type pronephric podocyte slit diaphragm, abnormal	AB + MO1-lmx1bb	standard conditions	Fig. 4 from He et al., 2014
optokinetic behavior decreased occurrence, abnormal	AB + MO1-lmx1bb	standard conditions	Fig. 6 from Wang et al., 2019
optokinetic behavior decreased process quality, abnormal	AB + MO1-lmx1bb	standard conditions	Fig. 6 from Wang et al., 2019
pronephric glomerular capillary increased diameter, abnormal	AB + MO1-lmx1bb	standard conditions	Fig. 4 from He et al., 2014

1 - 5 of 38 Show all

Citations

Include unpublished citations

Wang, F., Ren, D., Liang, X., Ke, S., Zhang, B., Hu, B., Song, X., Wang, X. (2019) A long noncoding RNA cluster-based genomic locus maintains proper development and visual function. Nucleic acids research. 47(12):6315-6329
He, B., Ebarasi, L., Zhao, Z., Guo, J., Ojala, J.R., Hultenby, K., De Val, S., Betsholtz, C., Tryggvason, K. (2014) Lmx1b and FoxC Combinatorially Regulate Podocin Expression in Podocytes. Journal of the American Society of Nephrology : JASN. 25(12):2764-77
Burghardt, T., Kastner, J., Suleiman, H., Rivera-Milla, E., Stepanova, N., Lottaz, C., Kubitza, M., Böger, C.A., Schmidt, S., Gorski, M., de Vries, U., Schmidt, H., Hertting, I., Kopp, J., Rascle, A., Moser, M., Heid, I.M., Warth, R., Spang, R., Wegener, J., Mierke, C.T., Englert, C., and Witzgall, R. (2013) LMX1B is Essential for the Maintenance of Differentiated Podocytes in Adult Kidneys. Journal of the American Society of Nephrology : JASN. 24(11):1830-48
Katherine, B.V., Roger, L.B., and Rodríguez, R.E. (2013) Cocaine modulates the expression of transcription factors related to the dopaminergic system in zebrafish. Neuroscience. 231:258-271
McMahon, C., Gestri, G., Wilson, S.W., and Link, B.A. (2009) Lmx1b is essential for survival of periocular mesenchymal cells and influences Fgf-mediated retinal patterning in zebrafish. Developmental Biology. 332(2):287-298
Elsen, G.E., Choi, L.Y., Millen, K.J., Grinblat, Y., and Prince, V.E. (2008) Zic1 and Zic4 regulate zebrafish roof plate specification and hindbrain ventricle morphogenesis. Developmental Biology. 314(2):376-392
Filippi, A., Duerr, K., Ryu, S., Willaredt, M., Holzschuh, J., and Driever, W. (2007) Expression and function of nr4a2, lmx1b, and pitx3 in zebrafish dopaminergic and noradrenergic neuronal development. BMC Developmental Biology. 7(1):135
O'Hara, F.P., Beck, E., Barr, L.K., Wong, L.L., Kessler, D.S., and Riddle, R.D. (2005) Zebrafish Lmx1b.1 and Lmx1b.2 are required for maintenance of the isthmic organizer. Development (Cambridge, England). 132(14):3163-3173

1 - 8 of 8

Show