Gene
lmx1bb
- ID
- ZDB-GENE-050114-2
- Name
- LIM homeobox transcription factor 1, beta b
- Symbol
- lmx1bb Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Is predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in neuron differentiation and regulation of transcription by RNA polymerase II. Acts upstream of or within animal organ development and glutamatergic neuron differentiation. Is expressed in several structures, including axis; midbrain hindbrain boundary neural keel; midbrain hindbrain boundary neural rod; nervous system; and otic vesicle. Human ortholog(s) of this gene implicated in focal segmental glomerulosclerosis and nail-patella syndrome. Orthologous to human LMX1B (LIM homeobox transcription factor 1 beta).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 25 figures from 14 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 16 figures from 6 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
nail-patella syndrome | Alliance | Nail-patella syndrome | 161200 |
Focal segmental glomerulosclerosis 10 | 256020 |
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Length | Homeobox, conserved site | Homeobox domain | Homeobox-like domain superfamily | Zinc finger, LIM-type |
---|---|---|---|---|---|
UniProtKB:Q4L1M6
|
375 | ||||
UniProtKB:Q4VJ29
|
375 | ||||
UniProtKB:Q5CD70
|
119 |
Type | Name | Length (nt) | Analysis |
---|---|---|---|
mRNA |
lmx1bb-201
(1)
|
1952 nt | |
ncRNA |
lmx1bb-002
(1)
|
697 nt |
Interactions and Pathways
No data available
Plasmids
No data available