Gene
lmx1bb
- ID
- ZDB-GENE-050114-2
- Name
- LIM homeobox transcription factor 1, beta b
- Symbol
- lmx1bb Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including embryonic organ morphogenesis; glomerulus development; and nervous system development. Predicted to be active in nucleus. Is expressed in several structures, including axis; midbrain hindbrain boundary neural keel; midbrain hindbrain boundary neural rod; nervous system; and otic vesicle. Human ortholog(s) of this gene implicated in nail-patella syndrome. Orthologous to human LMX1B (LIM homeobox transcription factor 1 beta).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 30 figures from 17 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 16 figures from 6 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| jj410 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| la016356Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa14923 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa34444 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa34445 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa41254 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-lmx1bb | Swinburne et al., 2018 | |
| CRISPR2-lmx1bb | Swinburne et al., 2018 | |
| CRISPR3-lmx1bb | Mori et al., 2024 | |
| CRISPR4-lmx1bb | Mori et al., 2024 | |
| CRISPR5-lmx1bb | Mori et al., 2024 | |
| MO1-lmx1bb | N/A | (8) |
| MO2-lmx1bb | N/A | (2) |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| nail-patella syndrome | Alliance | Nail-patella syndrome | 161200 |
| Focal segmental glomerulosclerosis 10 | 256020 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Homedomain-like superfamily | Homeobox, conserved site | Homeodomain | LIM/homeobox transcription factors | Zinc finger, LIM-type |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q4VJ29 | InterPro | 375 | |||||
| UniProtKB:Q4L1M6 | InterPro | 375 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
lmx1bb-201
(1)
|
Ensembl | 1,952 nt | ||
| mRNA |
lmx1bb-203
(1)
|
Ensembl | 3,812 nt | ||
| ncRNA |
lmx1bb-002
(1)
|
Ensembl | 697 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(-5.0lmx1bb:GFP) |
|
| 4 | (9) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-81G2 | ZFIN Curated Data | |
| Contained in | BAC | CH211-101A21 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-17A16 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194366 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194387 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001025167 (1) | 1952 nt | ||
| Genomic | GenBank:CR376762 (2) | 183602 nt | ||
| Polypeptide | UniProtKB:Q4L1M6 (1) | 375 aa |
- Mori, Y., Smith, S., Wang, J., Eliora, N., Heikes, K.L., Munjal, A. (2024) Versican controlled by Lmx1b regulates hyaluronate density and hydration for semicircular canal morphogenesis. Development (Cambridge, England). 152(1):
- Ahmed, I., Ziab, M., Da'as, S., Hasan, W., Jeya, S.P., Aliyev, E., Nisar, S., Bhat, A.A., Fakhro, K.A., Alshabeeb Akil, A.S. (2023) Network-based identification and prioritization of key transcriptional factors of diabetic kidney disease. Computational and structural biotechnology journal. 21:716730716-730
- Chen, F., Köhler, M., Cucun, G., Takamiya, M., Kizil, C., Cosacak, M.I., Rastegar, S. (2023) sox1a:eGFP transgenic line and single-cell transcriptomics reveal the origin of zebrafish intraspinal serotonergic neurons. iScience. 26:107342107342
- Pan, W., Godoy, R.S., Cook, D.P., Scott, A.L., Nurse, C.A., Jonz, M.G. (2022) Single-cell transcriptomic analysis of neuroepithelial cells and other cell types of the gills of zebrafish (Danio rerio) exposed to hypoxia. Scientific Reports. 12:10144
- Vöcking, O., Van Der Meulen, K., Patel, M.K., Famulski, J.K. (2022) Zebrafish anterior segment mesenchyme progenitors are defined by function of tfap2a but not sox10. Differentiation; research in biological diversity. 130:324232-42
- Brown, C., Mullins, L.J., Wesencraft, K., McConnell, G., Beltran, M., Henderson, N.C., Conway, B., Hoffmann, S., Rider, S., Mullins, J.J. (2021) scRNA Transcription Profile of Adult Zebrafish Podocytes Using a Novel Reporter Strain. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 55:35-47
- Adusumilli, L., Facchinello, N., Teh, C., Busolin, G., Le, M.T., Yang, H., Beffagna, G., Campanaro, S., Tam, W.L., Argenton, F., Lim, B., Korzh, V., Tiso, N. (2020) miR-7 Controls the Dopaminergic/Oligodendroglial Fate through Wnt/β-catenin Signaling Regulation. Cells. 9(3):
- Albadri, S., Armant, O., Aljand-Geschwill, T., Del Bene, F., Carl, M., Strähle, U., Poggi, L. (2020) Expression of a Barhl1a reporter in subsets of retinal ganglion cells and commissural neurons of the developing zebrafish brain. Scientific Reports. 10:8814
- Van Der Meulen, K.L., Vöcking, O., Weaver, M.L., Meshram, N.N., Famulski, J.K. (2020) Spatiotemporal Characterization of Anterior Segment Mesenchyme Heterogeneity During Zebrafish Ocular Anterior Segment Development. Frontiers in cell and developmental biology. 8:379
- Wong, C.E.D., Hua, K., Monis, S., Saxena, V., Norazit, A., Noor, S.M., Ekker, M. (2020) Gdnf affects early diencephalic dopaminergic neuron development through regulation of differentiation-associated transcription factors in zebrafish. Journal of neurochemistry. 156(4):481-498
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