Gene

lmx1bb

ID

ZDB-GENE-050114-2

Name

LIM homeobox transcription factor 1, beta b

Symbol

lmx1bb Nomenclature History

Previous Names

lmx1b.1
lmx1b (1)
alo (1)

Type

protein_coding_gene

Location

Chr: 8 Mapping Details/Browsers

Description

Is predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in neuron differentiation and regulation of transcription by RNA polymerase II. Acts upstream of or within animal organ development and glutamatergic neuron differentiation. Is expressed in several structures, including axis; midbrain hindbrain boundary neural keel; midbrain hindbrain boundary neural rod; nervous system; and otic vesicle. Human ortholog(s) of this gene implicated in focal segmental glomerulosclerosis and nail-patella syndrome. Orthologous to human LMX1B (LIM homeobox transcription factor 1 beta).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

25 figures from 14 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 16 figures from 6 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With lmx1bb Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
nail-patella syndrome	Alliance	Nail-patella syndrome	161200
		Focal segmental glomerulosclerosis 10	256020

Associated With lmx1bb Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR017970	Homeobox, conserved site
Domain	IPR001356	Homeobox domain
Domain	IPR001781	Zinc finger, LIM-type
Homologous_superfamily	IPR009057	Homeobox-like domain superfamily

Domain Details Per Protein

Protein	Length	Homeobox, conserved site	Homeobox domain	Homeobox-like domain superfamily	Zinc finger, LIM-type
UniProtKB:Q4L1M6 InterPro	375
UniProtKB:Q4VJ29 InterPro	375
UniProtKB:Q5CD70 InterPro	119

Transcripts

Genome Browsers

Type	Name	Length (nt)	Analysis
mRNA	lmx1bb-201 (1) Ensembl	1952 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	lmx1bb-002 (1) Ensembl	697 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations