ZFIN Morpholino: MO1-nfe2l2a

Target Location

Genome Build: GRCz11Chromosome: 9

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-nfe2l2a

No data available

Phenotype

Phenotype resulting from MO1-nfe2l2a

Phenotype	Fish	Figures
anatomical structure glutathione decreased amount, abnormal	TL + MO1-nfe2l2a	Fig. 4 from Sant et al., 2017
anatomical structure glutathione disulfide increased amount, abnormal	TL + MO1-nfe2l2a	Fig. 4, Fig. 6 from Sant et al., 2017
caudal hematopoietic tissue blvrb expression increased amount, abnormal	TL + MO1-nfe2l2a	Fig. 5 from Holowiecki et al., 2017
glutathione disulfide oxidoreductase activity increased occurrence, abnormal	TL + MO1-nfe2l2a	Fig. 4, Fig. 6 from Sant et al., 2017
whole organism EGFP expression decreased amount, abnormal	it416bTg + MO1-nfe2l2a	Fig. S8 from Poganik et al., 2019

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Phenotype of all Fish created by or utilizing MO1-nfe2l2a

Phenotype	Fish	Conditions	Figures
gill gstp1.2 expression amount, ameliorated	AB + MO1-nfe2l2a	chemical treatment: tunicamycin	Fig. 3 from Mukaigasa et al., 2018
gill gstp1.2 expression amount, ameliorated	AB + MO1-nfe2l2a	chemical treatment: thapsigargin	Fig. 3 from Mukaigasa et al., 2018
caudal hematopoietic tissue blvrb expression amount, ameliorated	TL + MO1-nfe2l2a	chemical treatment by environment: elemental cadmium	Fig. 5 from Holowiecki et al., 2017
whole organism blvrb expression amount, ameliorated	TL + MO1-nfe2l2a	chemical treatment by environment: cadmium dichloride	Fig. 8 from Holowiecki et al., 2016
liver hmox1a expression amount, ameliorated	TL + MO1-nfe2l2a	chemical treatment by environment: elemental cadmium	Fig. 5 from Holowiecki et al., 2017

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Citations

Include unpublished citations

Abate, G., Pezzotta, A., Pucci, M., Bortolotto, V., Ribaudo, G., Bonini, S.A., Mastinu, A., Maccarinelli, G., Ongaro, A., Tirelli, E., Zizioli, D., Gianoncelli, A., Memo, M., Grilli, M., Uberti, D. (2024) The Bioactive Gamma-Oryzanol from Oryza sativa L. Promotes Neuronal Differentiation in Different In Vitro and In Vivo Models. Antioxidants (Basel, Switzerland). 13(8):
Chang, S.H., Giong, H.K., Kim, D.Y., Kim, S., Oh, S., Yun, U.J., Lee, J.S., Park, K.W. (2023) Activation of Nrf2 by sulfuretin stimulates chondrocyte differentiation and increases bone lengths in zebrafish. BMB reports. 56:496501496-501
Van Hall-Beauvais, A., Poganik, J.R., Huang, K.T., Parvez, S., Zhao, Y., Lin, H.Y., Liu, X., Long, M.J.C., Aye, Y. (2022) Z-REX uncovers a bifurcation in function of Keap1 paralogs. eLIFE. 11:
Guan, R., Wen, X.Y., Leung, C.H., Ciano-Oliveira, C.D., Lam, S., Dai, S.Y., Karbassi, F., Mauro, A., Wang, Y., Rotstein, O. (2021) Plasma obtained following murine hindlimb ischemic conditioning protects against oxidative stress in zebrafish models through activation of nrf2a and downregulation of duox. PLoS One. 16:e0260442
Sant, K.E., Moreau, H.M., Williams, L.M., Jacobs, H.M., Bowsher, A.M., Boisvert, J.D., Smolowitz, R.M., Pantazis, J., Annunziato, K., Nguyen, M., Timme-Laragy, A. (2020) Embryonic exposures to mono-2-ethylhexyl phthalate induce larval steatosis in zebrafish independent of Nrf2a signaling. Journal of developmental origins of health and disease. 12(1):132-140
Li, H., Zhang, Q., Li, W., Li, H., Bao, J., Yang, C., Wang, A., Wei, J., Chen, S., Jin, H. (2019) Role of Nrf2 in the antioxidation and oxidative stress induced developmental toxicity of honokiol in zebrafish. Toxicology and applied pharmacology. 373:48-61
Poganik, J.R., Long, M.J.C., Disare, M.T., Liu, X., Chang, S.H., Hla, T., Aye, Y. (2019) Post-transcriptional regulation of Nrf2-mRNA by the mRNA-binding proteins HuR and AUF1. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33(12):14636-14652
Mukaigasa, K., Tsujita, T., Nguyen, V.T., Li, L., Yagi, H., Fuse, Y., Nakajima-Takagi, Y., Kato, K., Yamamoto, M., Kobayashi, M. (2018) Nrf2 activation attenuates genetic endoplasmic reticulum stress induced by a mutation in the phosphomannomutase 2 gene in zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 115(11):2758-2763
Holowiecki, A., O'Shields, B., Jenny, M.J. (2017) Spatiotemporal expression and transcriptional regulation of heme oxygenase and biliverdin reductase genes in zebrafish (Danio rerio) suggest novel roles during early developmental periods of heightened oxidative stress. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 191:138-151
Sant, K.E., Hansen, J.M., Williams, L.M., Tran, N.L., Goldstone, J.V., Stegeman, J.J., Hahn, M.E., Timme-Laragy, A. (2017) The role of Nrf1 and Nrf2 in the regulation of glutathione and redox dynamics in the developing zebrafish embryo. Redox Biology. 13:207-218

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