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ZFIN ID: ZDB-LAB-180327-1
Chemical Biology Nestlé Institute of Health Sciences
PI/Director: Gut, Philipp
Contact Person: Gut, Philipp
Email: Philipp.gut@rd.nestle.com
URL:
Address:
Country: Switzerland
Phone: +41 21 632 6303
Fax:
Line Designation: nei


GENOMIC FEATURES ORIGINATING FROM THIS LAB
Show all 13 genomic features


STATEMENT OF RESEARCH INTERESTS
We study mechanisms of metabolic homeostasis in zebrafish and leverage small molecule screening capabilities to identify new modulators of metabolic control.


LAB MEMBERS
Civiletto, Gabriele Post-Doc Parisi, Alice Post-Doc Richard, Joy Research Staff


ZEBRAFISH PUBLICATIONS OF LAB MEMBERS
Gut, P., Matilainen, S., Meyer, J.G., Pällijeff, P., Richard, J., Carroll, C.J., Euro, L., Jackson, C.B., Isohanni, P., Minassian, B.A., Alkhater, R.A., Østergaard, E., Civiletto, G., Parisi, A., Thevenet, J., Rardin, M.J., He, W., Nishida, Y., Newman, J.C., Liu, X., Christen, S., Moco, S., Locasale, J.W., Schilling, B., Suomalainen, A., Verdin, E. (2020) SUCLA2 mutations cause global protein succinylation contributing to the pathomechanism of a hereditary mitochondrial disease. Nature communications. 11:5927
Weger, M., Weger, B.D., Schink, A., Takamiya, M., Stegmaier, J., Gobet, C., Parisi, A., Kobitski, A.Y., Mertes, J., Krone, N., Strähle, U., Nienhaus, G.U., Mikut, R., Gachon, F., Gut, P., Dickmeis, T. (2020) MondoA regulates gene expression in cholesterol biosynthesis-associated pathways required for zebrafish epiboly. eLIFE. 9:
Arribat, Y., Grepper, D., Lagarrigue, S., Richard, J., Gachet, M., Gut, P., Amati, F. (2019) Mitochondria in Embryogenesis: An Organellogenesis Perspective. Frontiers in cell and developmental biology. 7:282
Collodet, C., Foretz, M., Deak, M., Bultot, L., Metairon, S., Viollet, B., Lefebvre, G., Raymond, F., Parisi, A., Civiletto, G., Gut, P., Descombes, P., Sakamoto, K. (2019) AMPK promotes induction of the tumor suppressor FLCN through activation of TFEB independently of mTOR. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33(11):12374-12391
Dumesic, P.A., Egan, D.F., Gut, P., Tran, M.T., Parisi, A., Chatterjee, N., Jedrychowski, M., Paschini, M., Kazak, L., Wilensky, S.E., Dou, F., Bogoslavski, D., Cartier, J.A., Perrimon, N., Kajimura, S., Parikh, S.M., Spiegelman, B.M. (2019) An Evolutionarily Conserved uORF Regulates PGC1α and Oxidative Metabolism in Mice, Flies, and Bluefin Tuna. Cell Metabolism. 30:190-200.e6
Dickmeis, T., Feng, Y., Mione, M.C., Ninov, N., Santoro, M., Spaink, H.P., Gut, P. (2019) Nano-Sampling and Reporter Tools to Study Metabolic Regulation in Zebrafish. Frontiers in cell and developmental biology. 7:15
Blattmann, P., Stutz, V., Lizzo, G., Richard, J., Gut, P., Aebersold, R. (2019) Generation of a zebrafish SWATH-MS spectral library to quantify 10,000 proteins. Scientific data. 6:190011
Eubelen, M., Bostaille, N., Cabochette, P., Gauquier, A., Tebabi, P., Dumitru, A.C., Koehler, M., Gut, P., Alsteens, D., Stainier, D.Y.R., Garcia-Pino, A., Vanhollebeke, B. (2018) A molecular mechanism for Wnt ligand-specific signaling. Science (New York, N.Y.). 361(6403):
Weger, M., Diotel, N., Weger, B.D., Beil, T., Zaucker, A., Eachus, H.L., Oakes, J.A., do Rego, J.L., Storbeck, K.H., Gut, P., Straehle, U., Rastegar, S., Mueller, F., Krone, N. (2018) Expression and activity profiling of the steroidogenic enzymes of glucocorticoid biosynthesis and the fdx1 co-factors in zebrafish. Journal of neuroendocrinology. 30(4):e12586
Gut, P., Reischauer, S., Stainier, D.Y.R., Arnaout, R. (2017) Little Fish, Big Data: Zebrafish as a Model for Cardiovascular and Metabolic Disease. Physiological reviews. 97:889-938
Gut, P. (2015) Targeting mitochondrial energy metabolism with TSPO ligands. Biochemical Society transactions. 43:537-542
Schlegel, A., Gut, P. (2015) Metabolic insights from zebrafish genetics, physiology, and chemical biology. Cellular and molecular life sciences : CMLS. 72(12):2249-60
Gut, P., Stainier, D.Y. (2015) Whole-Organism Screening for Modulators of Fasting Metabolism Using Transgenic Zebrafish. Methods in molecular biology (Clifton, N.J.). 1263:157-165
Tsuji, N., Ninov, N., Delawary, M., Osman, S., Roh, A.S., Gut, P., Stainier, D.Y. (2014) Whole Organism High Content Screening Identifies Stimulators of Pancreatic Beta-Cell Proliferation. PLoS One. 9:e104112
Ninov, N., Hesselson, D., Gut, P., Zhou, A., Fidelin, K., and Stainier, D.Y. (2013) Metabolic Regulation of Cellular Plasticity in the Pancreas. Current biology : CB. 23(13):1242-50
Gut, P., Baeza-Raja, B., Andersson, O., Hasenkamp, L., Hsiao, J., Hesselson, D., Akassoglou, K., Verdin, E., Hirschey, M.D., and Stainier, D.Y. (2013) Whole-organism screening for gluconeogenesis identifies activators of fasting metabolism. Nature Chemical Biology. 9(2):97-104
Andersson, O., Adams, B.A., Yoo, D., Ellis, G.C., Gut, P., Anderson, R.M., German, M.S., and Stainier, D.Y. (2012) Adenosine Signaling Promotes Regeneration of Pancreatic beta Cells In Vivo. Cell Metabolism. 15(6):885-894
Jurczyk, A., Roy, N., Bajwa, R., Gut, P., Lipson, K., Yang, C., Covassin, L., Racki, W.J., Rossini, A.A., Phillips, N., Stainier, D.Y., Greiner, D.L., Brehm, M.A., Bortell, R., and diIorio, P. (2011) Dynamic glucoregulation and mammalian-like responses to metabolic and developmental disruption in zebrafish. General and comparative endocrinology. 170(2):334-345