ZFIN ID: ZDB-LAB-110912-3
Monk Lab
PI/Director: Monk, Kelly
Contact Person: Monk, Kelly
Email: monk@ohsu.edu
URL: https://www.ohsu.edu/xd/research/centers-institutes/vollum/faculty/monklab.cfm
Address: Kelly Monk Lab Vollum Institute, L474 Oregon Health & Science University 3181 S.W. Sam Jackson Pk. Rd. Portland, Oregon 97239
Country: United States
Phone: 503-494-2980
Line Designation: vo

Show all 17 genomic features

The myelin sheath surrounding axons is an exquisite example of a specialized cell-cell interaction in the vertebrate nervous system. Myelin is formed by glial cells called oligodendrocytes in the central nervous system and Schwann cells in the peripheral nervous system. These cells associate with axons, and elaborate massive amounts of cytoplasm, ultimately wrapping axons to form the myelin sheath. While much progress has been made to determine how glial cells make myelin, there is still much we do not understand. How do glial cells transition from simple axonal ensheathment to membrane spiraling? What are the signals between glial cells and axons that regulate myelination? How is myelin maintained once it is formed? When myelin regenerates in disease or after injury, do the same developmental pathways that regulate myelination regulate remyelination? We use mouse and zebrafish models to better understand how myelinated axons are formed, maintained, and regenerated.


Nagai, J., Yu, X., Papouin, T., Cheong, E., Freeman, M.R., Monk, K.R., Hastings, M.H., Haydon, P.G., Rowitch, D., Shaham, S., Khakh, B.S. (2020) Behaviorally consequential astrocytic regulation of neural circuits. Neuron. 109(4):576-596
Gray, R.S., Gonzalez, R., Ackerman, S.D., Minowa, R., Griest, J.F., Bayrak, M.N., Troutwine, B., Canter, S., Monk, K.R., Sepich, D.S., Solnica-Krezel, L. (2020) Postembryonic screen for mutations affecting spine development in zebrafish. Developmental Biology. 471:18-33
Chen, J., Poskanzer, K.E., Freeman, M.R., Monk, K.R. (2020) Live-imaging of astrocyte morphogenesis and function in zebrafish neural circuits. Nature Neuroscience. 23(10):1297-1306
Leon, K., Cunningham, R.L., Riback, J.A., Feldman, E., Li, J., Sosnick, T.R., Zhao, M., Monk, K.R., Araç, D. (2020) Structural basis for adhesion G protein-coupled receptor Gpr126 function. Nature communications. 11:194
Bradley, E.C., Cunningham, R.L., Wilde, C., Morgan, R.K., Klug, E.A., Letcher, S.M., Schöneberg, T., Monk, K.R., Liebscher, I., Petersen, S.C. (2019) In vivo identification of small molecules mediating Gpr126/Adgrg6 signaling during Schwann cell development. Annals of the New York Academy of Sciences. 1456(1):44-63
Cunningham, R.L., Herbert, A.L., Harty, B.L., Ackerman, S.D., Monk, K.R. (2018) Mutations in dock1 disrupt early Schwann cell development. Neural Development. 13:17
Giera, S., Luo, R., Ying, Y., Ackerman, S.D., Jeong, S.J., Stoveken, H.M., Folts, C.J., Welsh, C.A., Tall, G.G., Stevens, B., Monk, K.R., Piao, X. (2018) Microglial transglutaminase-2 drives myelination and myelin repair via GPR56/ADGRG1 in oligodendrocyte precursor cells. eLIFE. 7
Ackerman, S.D., Luo, R., Poitelon, Y., Mogha, A., Harty, B.L., D'Rozario, M., Sanchez, N.E., Lakkaraju, A.K.K., Gamble, P., Li, J., Qu, J., MacEwan, M.R., Ray, W.Z., Aguzzi, A., Feltri, M.L., Piao, X., Monk, K.R. (2018) GPR56/ADGRG1 regulates development and maintenance of peripheral myelin. The Journal of experimental medicine. 215(3):941-961
Cunningham, R.L., Monk, K.R. (2018) Transmission Electron Microscopy for Zebrafish Larvae and Adult Lateral Line Nerve. Methods in molecular biology (Clifton, N.J.). 1739:385-400
Cunningham, R.L., Monk, K.R. (2018) Live Imaging of Schwann Cell Development in Zebrafish. Methods in molecular biology (Clifton, N.J.). 1739:401-405
Cunningham, R.L., Monk, K.R. (2018) Whole Mount In Situ Hybridization and Immunohistochemistry for Zebrafish Larvae. Methods in molecular biology (Clifton, N.J.). 1739:371-384
Herbert, A.L., Fu, M.M., Drerup, C.M., Gray, R.S., Harty, B.L., Ackerman, S.D., O'Reilly-Pol, T., Johnson, S.L., Nechiporuk, A.V., Barres, B.A., Monk, K.R. (2017) Dynein/dynactin is necessary for anterograde transport of Mbp mRNA in oligodendrocytes and for myelination in vivo.. Proceedings of the National Academy of Sciences of the United States of America. 114:E9153-E9162
Sanchez, N.E., Harty, B.L., O'Reilly-Pol, T., Ackerman, S.D., Herbert, A.L., Holmgren, M., Johnson, S.L., Gray, R.S., Monk, K.R. (2017) Whole Genome Sequencing-Based Mapping and Candidate Identification of Mutations from Fixed Zebrafish Tissue. G3 (Bethesda). 7(10):3415-3425
Drerup, C.M., Herbert, A.L., Monk, K.R., Nechiporuk, A.V. (2017) Regulation of mitochondria-dynactin interaction and mitochondrial retrograde transport in axons. eLIFE. 6
Küffer, A., Lakkaraju, A.K., Mogha, A., Petersen, S.C., Airich, K., Doucerain, C., Marpakwar, R., Bakirci, P., Senatore, A., Monnard, A., Schiavi, C., Nuvolone, M., Grosshans, B., Hornemann, S., Bassilana, F., Monk, K.R., Aguzzi, A. (2016) The prion protein is an agonistic ligand of the G protein-coupled receptor Adgrg6. Nature. 536(7617):464-8
Ackerman, S.D., Monk, K.R. (2016) The scales and tales of myelination: using zebrafish and mouse to study myelinating glia. Brain research. 1641(Pt A):79-91
Liebscher, I., Monk, K.R., Schöneberg, T. (2015) How to wake a giant. Oncotarget. 6:23038-9
Petersen, S.C., Luo, R., Liebscher, I., Giera, S., Jeong, S.J., Mogha, A., Ghidinelli, M., Feltri, M.L., Schöneberg, T., Piao, X., Monk, K.R. (2015) The adhesion GPCR GPR126 has distinct, domain-dependent functions in Schwann cell development mediated by interaction with laminin-211. Neuron. 85:755-69
Harty, B.L., Krishnan, A., Sanchez, N.E., Schiöth, H.B., Monk, K.R. (2015) Defining the gene repertoire and spatiotemporal expression profiles of adhesion G protein-coupled receptors in zebrafish. BMC Genomics. 16:62
Ackerman, S.D., Garcia, C., Piao, X., Gutmann, D.H., Monk, K.R. (2015) The adhesion GPCR Gpr56 regulates oligodendrocyte development via interactions with Gα12/13 and RhoA. Nature communications. 6:6122
Liebscher, I., Schön, J., Petersen, S.C., Fischer, L., Auerbach, N., Demberg, L.M., Mogha, A., Cöster, M., Simon, K., Rothemund, S., Monk, K.R., Schöneberg, T. (2014) A Tethered Agonist within the Ectodomain Activates the Adhesion G Protein-Coupled Receptors GPR126 and GPR133. Cell Reports. 9(6):2018-26
Patra, C., Monk, K.R., Engel, F.B. (2014) The multiple signaling modalities of adhesion G protein-coupled receptor GPR126 in development. Receptors & clinical investigation. 1:79
Shiau, C.E., Monk, K.R., Joo, W., and Talbot, W.S. (2013) An Anti-inflammatory NOD-like Receptor Is Required for Microglia Development. Cell Reports. 5(5):1342-1352
Patra, C., van Amerongen, M.J., Ghosh, S., Ricciardi, F., Sajjad, A., Novoyatleva, T., Mogha, A., Monk, K.R., Mühlfeld, C., and Engel, F.B. (2013) Organ-specific function of adhesion G protein-coupled receptor GPR126 is domain-dependent. Proceedings of the National Academy of Sciences of the United States of America. 110(42):16898-16903
Monk, K.R., Voas, M.G., Franzini-Armstrong, C., Hakkinen, I.S., and Talbot, W.S. (2013) Mutation of sec63 in zebrafish causes defects in myelinated axons and liver pathology. Disease models & mechanisms. 6(1):135-145
Monk, K.R., and Talbot, W.S. (2009) Genetic dissection of myelinated axons in zebrafish. Current opinion in neurobiology. 19(5):486-490
Monk, K.R., Naylor, S.G., Glenn, T.D., Mercurio, S., Perlin, J.R., Dominguez, C., Moens, C.B., and Talbot, W.S. (2009) A G protein-coupled receptor is essential for Schwann cells to initiate myelination. Science (New York, N.Y.). 325(5946):1402-1405