ZFIN ID: ZDB-LAB-110408-2
Haramis Lab
PI/Director: Haramis, Anna-Pavlina
Contact Person: Haramis, Anna-Pavlina
Email: a.haramis@biology.leidenuniv.nl
URL: http://www.science.leidenuniv.nl/index.php/ibl/haramis
Address: Institute of Biology Leiden (IBL), Leiden University Sylvius Laboratory, Room 06.05.16b Sylviusweg 72, 2333 BE, Leiden, The Netherlands
Country: Netherlands
Phone: 0031 71 527 4782
Fax:
Line Designation: ibl


GENOMIC FEATURES ORIGINATING FROM THIS LAB
Show all 2 genomic features


STATEMENT OF RESEARCH INTERESTS
We are studying the developmental roles of oncogenes and tumor suppressors in zebrafish.
Our research focuses on the regulation of tissue homeostasis by extrinsic factors (energy supply) and intrinsic mechanisms (epigenetic regulation of differentiation) using zebrafish as our central experimental model.
We are following two main lines of research:
1) Energy homeostasis in development and disease, employing mainly our lkb1 model of deregulated metabolism.
2) Epigenetic regulation of tissue homeostasis, employing zebrafish mutanted in ring1b, a Polycomb gene.


LAB MEMBERS


ZEBRAFISH PUBLICATIONS OF LAB MEMBERS
van Veen, M., Mans, L.A., Matas-Rico, E., van Pelt, J., Perrakis, A., Moolenaar, W.H., Haramis, A.G. (2017) Glycerophosphodiesterase GDE2/GDPD5 affects pancreas differentiation in zebrafish. The international journal of biochemistry & cell biology. 94:71-78
Mans, L.A., Querol Cano, L., van Pelt, J., Giardoglou, P., Keune, W.J., Haramis, A.G. (2017) The tumor suppressor LKB1 regulates starvation-induced autophagy under systemic metabolic stress. Scientific Reports. 7:7327
Stijf-Bultsma, Y., Sommer, L., Tauber, M., Baalbaki, M., Giardoglou, P., Jones, D.R., Gelato, K.A., van Pelt, J., Shah, Z., Rahnamoun, H., Toma, C., Anderson, K.E., Hawkins, P., Lauberth, S.M., Haramis, A.P., Hart, D., Fischle, W., Divecha, N. (2015) The basal transcription complex component TAF3 transduces changes in nuclear phosphoinositides into transcriptional output. Molecular Cell. 58:453-67
van der Velden, Y.U., Wang, L., Querol Cano, L., and Haramis, A.P. (2013) The polycomb group protein ring1b/rnf2 is specifically required for craniofacial development. PLoS One. 8(9):e73997
Elouarrat, D., van der Velden, Y., Jones, D.R., Moolenaar, W.H., Divecha, N., and Haramis, A.P. (2013) Role of phosphatidylinositol 5-phosphate 4-kinase α in zebrafish development. The international journal of biochemistry & cell biology. 45(7):1293-301
van der Velden, Y.U., Wang, L., van Lohuizen, M., and Haramis, A.P. (2012) The Polycomb group protein Ring1b is essential for pectoral fin development. Development (Cambridge, England). 139(12):2210-2220
van der Velden, Y.U., and Haramis, A.P. (2011) Insights from model organisms on the functions of the tumor suppressor protein LKB1: zebrafish chips in. Aging. 3(4):363-367
van der Velden, Y.U., Wang, L., Zevenhoven, J., van Rooijen, E., van Lohuizen, M., Giles, R.H., Clevers, H., and Haramis, A.P. (2011) The serine-threonine kinase LKB1 is essential for survival under energetic stress in zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 108(11):4358-4363
Brennan, C., Dosch, R., Haramis, A.P., Luckenbacher, T., Martinez-Morales, J.R., Moro, E., Polok, B., Ramesh, T.M., Russell, C., Argenton, F., and Strähle, U. (2010) Report of the European Zebrafish Principal Investigator Meeting in Padua, Italy, March 18-22, 2010. Zebrafish. 7(3):305-310
Goessling, W., North, T.E., Lord, A.M., Ceol, C., Lee, S., Weidinger, G., Bourque, C., Strijbosch, R., Haramis, A.P., Puder, M., Clevers, H., Moon, R.T., and Zon, L.I. (2008) APC mutant zebrafish uncover a changing temporal requirement for wnt signaling in liver development. Developmental Biology. 320(1):161-174
Hawkins, T.A., Haramis, A.P., Etard, C., Prodromou, C., Vaughan, C.K., Ashworth, R., Ray, S., Behra, M., Holder, N., Talbot, W.S., Pearl, L.H., Strähle, U., and Wilson, S.W. (2008) The ATPase-dependent chaperoning activity of Hsp90a regulates thick filament formation and integration during skeletal muscle myofibrillogenesis. Development (Cambridge, England). 135(6):1147-1156
Muncan, V., Faro, A., Haramis, A.P., Hurlstone, A.F., Wienholds, E., van Es, J., Korving, J., Begthel, H., Zivkovic, D., and Clevers, H. (2007) T-cell factor 4 (Tcf7l2) maintains proliferative compartments in zebrafish intestine. EMBO reports. 8(10):966-973
Haramis, A.P., Hurlstone, A., van der Velden, Y., Begthel, H., van den Born, M., Offerhaus, G.J., and Clevers, H.C. (2006) Adenomatous polyposis coli-deficient zebrafish are susceptible to digestive tract neoplasia. EMBO reports. 7(4):444-449
Hurlstone, A.F., Haramis, A.P., Wienholds, E., Begthel, H., Korving, J., van Eeden, F., Cuppen, E., Zivkovic, D., Plasterk, R.H., and Clevers, H. (2003) The Wnt/beta-catenin pathway regulates cardiac valve formation. Nature. 425(6958):633-637