ZFIN ID: ZDB-LAB-080130-1
Allison Lab
PI/Director: Allison, Ted
Contact Person: Allison, Ted
Email: ted.allison@ualberta.ca
URL: http://www.biology.ualberta.ca/allison_lab/
Address: Department of Biological Sciences & Centre for Prions and Protein Folding Diseases G-315, Biological Sciences Centre University of Alberta Edmonton, Alberta Canada T6G 2E9
Country: Canada
Phone: (780) 492-4430
Fax: (780) 492-9234
Line Designation: ua

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Research in Ted Allison's laboratory focuses on neurodegeneration and neural regeneration, especially within the retina. We use an integrative approach spanning molecular biology, electrophysiology & behaviour to study the development of retinas in fishes and how they are tuned to get the most information available from the environment. Our research has three major streams: i) using zebrafish to investigate questions of photoreceptor development, patterning & regeneration as they pertain to human retinal degenerative disease; ii) The development of zebrafish as an effective model organism for the study of protein folding diseases such as Alzheimer and Prion-related Diseases; iii) Investigating the visual ecology of fishes - how and why do visual systems change over evolutionary time and during the life history of animals.

Fleisch, Valerie Post-Doc Acharya, Moulinath Bujold, Adina
Duval, Michèle Fraser, Brittany Kaiser, Darcy
Koduri, Harsha Leighton, Patricia Lund, Johanna
McCorry, Aleah Oel, Phil Wang, Hao

Alyenbaawi, H., Kanyo, R., Locskai, L.F., Kamali-Jamil, R., DuVal, M.G., Bai, Q., Wille, H., Burton, E.A., Allison, W.T. (2021) Seizures are a druggable mechanistic link between TBI and subsequent tauopathy. eLIFE. 10:
Noel, N.C.L., MacDonald, I.M., Allison, W.T. (2021) Zebrafish Models of Photoreceptor Dysfunction and Degeneration. Biomolecules. 11(1):
Oel, A.P., Neil, G.J., Dong, E.M., Balay, S.D., Collett, K., Allison, W.T. (2020) Nrl Is Dispensable for Specification of Rod Photoreceptors in Adult Zebrafish Despite Its Deeply Conserved Requirement Earlier in Ontogeny. iScience. 23:101805
Noel, N.C.L., Nadolski, N.J., Hocking, J.C., MacDonald, I.M., Allison, W.T. (2020) Progressive Photoreceptor Dysfunction and Age-Related Macular Degeneration-Like Features in rp1l1 Mutant Zebrafish. Cells. 9(10):
Özcan, G.G., Lim, S., Leighton, P., Allison, W.T., Rihel, J. (2020) Sleep is bi-directionally modified by amyloid beta oligomers. eLIFE. 9:
Kanyo, R., Wang, C.K., Locskai, L.F., Li, J., Allison, W.T., Kurata, H.T. (2020) Functional and behavioral signatures of Kv7 activator drug subtypes. Epilepsia. 61(8):1678-1690
Zarowny, L., Aggarwal, A., Rutten, V.M.S., Kolb, I., Project, T.G., Patel, R., Huang, H.Y., Chang, Y.F., Phan, T., Kanyo, R., Ahrens, M.B., Allison, W.T., Podgorski, K., Campbell, R.E. (2020) A bright and high-performance genetically encoded Ca2+ indicator based on mNeonGreen fluorescent protein. ACS sensors. 5(7):1959-1968
Miyashita, T., Baddam, P., Smeeton, J., Oel, A.P., Natarajan, N., Gordon, B., Palmer, A.R., Crump, J.G., Graf, D., Allison, W.T. (2020) nkx3.2 mutant zebrafish accommodate jaw joint loss through a phenocopy of the head shapes of Paleozoic jawless fish. The Journal of experimental biology. 223(Pt 15):
Kanyo, R., Leighton, P.L.A., Neil, G.J., Locskai, L.F., Allison, W.T. (2020) Amyloid-β precursor protein mutant zebrafish exhibit seizure susceptibility that depends on prion protein. Experimental neurology. 328:113283
Wang, M., Li, P., Wang, H., Dong, L., Wu, C., Zhao, Z. (2019) Identification and spatiotemporal expression of gpr161 genes in zebrafish. Gene. 730:144303
Sufian, M.S., Amin, M.R., Kanyo, R., Allison, W.T., Ali, D.W. (2019) CB1 and CB2 receptors play differential roles in early zebrafish locomotor development. The Journal of experimental biology. 222(Pt 16)
Lahola-Chomiak, A.A., Footz, T., Nguyen-Phuoc, K., Neil, G.J., Fan, B., Allen, K.F., Greenfield, D.S., Parrish, R.K., Linkroum, K., Pasquale, L.R., Leonhardt, R.M., Ritch, R., Javadiyan, S., Craig, J.E., Ted Allison, W., Lehmann, O.J., Walter, M.A., Wiggs, J.L. (2018) Non-Synonymous variants in Premelanosome Protein (PMEL) cause ocular pigment dispersion and pigmentary glaucoma. Human molecular genetics. 28(8):1298-1311
DuVal, M.G., Hinge, V.K., Snyder, N., Kanyo, R., Bratvold, J., Pokrishevsky, E., Cashman, N.R., Blinov, N., Kovalenko, A., Ted Allison, W. (2018) Tryptophan 32 mediates SOD1 toxicity in a in vivo motor neuron model of ALS and is a promising target for small molecule therapeutics. Neurobiology of disease. 124:297-310
DuVal, M.G., Allison, W.T. (2018) Photoreceptor Progenitors Depend Upon Coordination of gdf6a, thrβ, and tbx2b to Generate Precise Populations of Cone Photoreceptor Subtypes. Investigative ophthalmology & visual science. 59:6089-6101
Leighton, P.L.A., Kanyo, R., Neil, G.J., Pollock, N.M., Allison, W.T. (2018) Prion gene paralogs are dispensable for early zebrafish development but have non-additive roles in seizure susceptibility. The Journal of biological chemistry. 293(32):12576-12592
Leighton, P.L.A., Nadolski, N.J., Morrill, A., Hamilton, T.J., Allison, W.T. (2018) An ancient conserved role for prion protein in learning and memory. Biology Open. 7(1)
Noel, N.C.L., Allison, W.T. (2017) Connectivity of cone photoreceptor telodendria in the zebrafish retina. The Journal of comparative neurology. 526(4):609-625
DuVal, M.G., Allison, W.T. (2017) Impacts of the retinal environment and photoreceptor type on functional regeneration. Neural regeneration research. 12:376-379
Hagerman, G.F., Noel, N.C., Cao, S.Y., DuVal, M.G., Oel, A.P., Allison, W.T. (2016) Rapid Recovery of Visual Function Associated with Blue Cone Ablation in Zebrafish. PLoS One. 11:e0166932
Wang, H., He, L., Pei, Y., Chu, P., Huang, R., Li, Y., Liao, L., Zhu, Z., Wang, Y. (2016) Cloning and characterization of Bax1 and Bax2 genes of Ctenopharyngodon idellus and evaluation of transcript expression in response to grass carp reovirus infection. Fish physiology and biochemistry. 42(5):1369-82
Hanwell, D., Hutchinson, S.A., Collymore, C., Bruce, A.E., Louis, R., Ghalami, A., Allison, W.T., Ekker, M., Eames, B.F., Childs, S., Kurrasch, D.M., Gerlai, R., Thiele, T., Scott, I., Ciruna, B., Dowling, J.J., McFarlane, S., Huang, P., Wen, X.Y., Akimenko, M.A., Waskiewicz, A.J., Drapeau, P., Babiuk, L.A., Dragon, D., Smida, A., Buret, A.G., O'Grady, E., Wilson, J., Sowden-Plunkett, L., Tropepe, V. (2016) Restrictions on the Importation of Zebrafish into Canada Associated with Spring Viremia of Carp Virus. Zebrafish. 13 Suppl 1:S153-63
Kim, J.W., Yang, H.J., Oel, A.P., Brooks, M.J., Jia, L., Plachetzki, D.C., Li, W., Allison, W.T., Swaroop, A. (2016) Recruitment of Rod Photoreceptors from Short-Wavelength-Sensitive Cones during the Evolution of Nocturnal Vision in Mammals. Developmental Cell. 37:520-532
Yu, F., Wang, H., Liu, W., Lu, L. (2016) Grass carp Ctenopharyngodon idella Fibulin-4 as a potential interacting partner for grass carp reovirus outer capsid proteins. Fish & shellfish immunology. 48:169-74
Xu, D., Song, L., Wang, H., Xu, X., Wang, T., Lu, L. (2015) Proteomic analysis of cellular protein expression profiles in response to grass carp reovirus infection. Fish & shellfish immunology. 44(2):515-24
Wang, H., Mu, S., Zhang, F., Wang, H., Liu, H., Zhang, H., Kang, X. (2015) Effects of Atrazine on the Development of Neural System of Zebrafish, Danio rerio. BioMed Research International. 2015:976068
Huc-Brandt, S., Hieu, N., Imberdis, T., Cubedo, N., Silhol, M., Leighton, P.L., Domaschke, T., Allison, W.T., Perrier, V., Rossel, M. (2014) Zebrafish Prion Protein PrP2 Controls Collective Migration Process during Lateral Line Sensory System Development. PLoS One. 9:e113331
Podok, P., Wang, H., Xu, L., Xu, D., Lu, L. (2014) Characterization of myeloid-specific peroxidase, keratin 8, and dual specificity phosphatase 1 as innate immune genes involved in theresistance of crucian carp (Carassius auratus gibelio) to Cyprinid herpesvirus 2 infection. Fish & shellfish immunology. 41(2):531-40
Yoshimatsu, T., Williams, P.R., D'Orazi, F.D., Suzuki, S.C., Fadool, J.M., Allison, W.T., Raymond, P.A., Wong, R.O. (2014) Transmission from the dominant input shapes the stereotypic ratio of photoreceptor inputs onto horizontal cells. Nature communications. 5:3699
Duval, M.G., Oel, A.P., Allison, W.T. (2014) gdf6a is required for cone photoreceptor subtype differentiation and for the actions of tbx2b in determining rod versus cone photoreceptor fate. PLoS One. 9:e92991
DuVal, M.G., Gilbert, M.J., Watson, D.E., Zerulla, T.C., Tierney, K.B., Allison, W.T. (2014) Growth differentiation factor 6 as a putative risk factor in neuromuscular degeneration. PLoS One. 9:e89183
Pillay, L.M., Selland, L.G., Fleisch, V.C., Leighton, P.L., Cheng, C.S., Famulski, J.K., Ritzel, R.G., March, L.D., Wang, H., Allison, W.T., and Waskiewicz, A.J. (2013) Evaluating the Mutagenic Activity of Targeted Endonucleases Containing a Sharkey FokI Cleavage Domain Variant in Zebrafish. Zebrafish. 10(3):353-64
Fleisch, V.C., Leighton, P.L., Wang, H., Pillay, L.M., Ritzel, R.G., Bhinder, G., Roy, B., Tierney, K.B., Ali, D.W., Waskiewicz, A.J., and Allison, W.T. (2013) Targeted Mutation of the Gene Encoding Prion Protein in Zebrafish reveals a Conserved Role in Neuron Excitability. Neurobiology of disease. 55:11-25
Duval, M.G., Chung, H., Lehmann, O.J., and Allison, W.T. (2013) Longitudinal fluorescent observation of retinal degeneration and regeneration in zebrafish using fundus lens imaging. Molecular Vision. 19:1082-1095
Asai-Coakwell, M., March, L., Dai, X.H., Duval, M., Lopez, I., French, C.R., Famulski, J., De Baere, E., Francis, P.J., Sundaresan, P., Sauvé, Y., Koenekoop, R.K., Berry, F.B., Allison, W.T., Waskiewicz, A.J., and Lehmann, O.J. (2013) Contribution of growth differentiation factor 6-dependent cell survival to early-onset retinal dystrophies. Human molecular genetics. 22(7):1432-1442
Fraser, B., Duval, M.G., Wang, H., and Allison, W.T. (2013) Regeneration of cone photoreceptors when cell ablation is primarily restricted to a particular cone subtype. PLoS One. 8(1):e55410
Kaiser, D.M., Acharya, M., Leighton, P.L., Wang, H., Daude, N., Wohlgemuth, S., Shi, B., and Allison, W.T. (2012) Amyloid Beta precursor protein and prion protein have a conserved interaction affecting cell adhesion and CNS development. PLoS One. 7(12):e51305
Acharya, M., Huang, L., Fleisch, V.C., Allison, W.T., and Walter, M.A. (2011) A Complex Regulatory Network of Transcription Factors Critical for Ocular Development and Disease. Human molecular genetics. 20(8):1610-24
Allison, W.T. (2011) Preface to BBA: Molecular basis of disease special issue - Zebrafish models of neurology. Biochimica et biophysica acta. Molecular basis of disease. 1812(3):333-334
Fleisch, V.C., Fraser, B., and Allison, W.T. (2011) Investigating regeneration and functional integration of CNS neurons: Lessons from zebrafish genetics and other fish species. Biochimica et biophysica acta. Molecular basis of disease. 1812(3):364-380
Fleisch, V.C., and Neuhauss, S.C. (2010) Parallel visual cycles in the zebrafish retina. Progress in Retinal and Eye Research. 29(6):476-486
Allison, W.T., Barthel, L.K., Skebo, K.M., Takechi, M., Kawamura, S., and Raymond, P.A. (2010) Ontogeny of cone photoreceptor mosaics in zebrafish. The Journal of comparative neurology. 518(20):4182-4195
Ye, M., Berry-Wynne, K.M., Asai-Coakwell, M., Sundaresan, P., Footz, T., French, C.R., Abitbol, M., Fleisch, V.C., Corbett, N., Allison, W.T., Drummond, G., Walter, M.A., Underhill, T.M., Waskiewicz, A.J., and Lehmann, O.J. (2010) Mutation of the Bone Morphogenetic Protein GDF3 causes ocular and skeletal anomalies. Human molecular genetics. 19(2):287-298
Fleisch, V.C., Schonthaler, H.B., von Lintig, J., and Neuhauss, S.C. (2008) Subfunctionalization of a retinoid-binding protein provides evidence for two parallel visual cycles in the cone-dominant zebrafish retina. The Journal of neuroscience : the official journal of the Society for Neuroscience. 28(33):8208-8216
Jin, H.J., Shao, J.Z., Xiang, L.X., Wang, H., and Sun, L.L. (2008) Global identification and comparative analysis of SOCS genes in fish: insights into the molecular evolution of SOCS family. Molecular immunology. 45(5):1258-1268
Schonthaler, H.B., Fleisch, V.C., Biehlmaier, O., Makhankov, Y., Rinner, O., Bahadori, R., Geisler, R., Schwarz, H., Neuhauss, S.C., and Dahm, R. (2008) The zebrafish mutant lbk/vam6 resembles human multi-systemic disorders caused by aberrant trafficking of endosomal vesicles. Development (Cambridge, England). 135(2):387-399
Fleisch, V.C., and Neuhauss, S.C.F. (2006) Visual Behavior in Zebrafish. Zebrafish. 3(2):191-201
Allison, W.T., Haimberger, T.J., Hawryshyn, C.W., and Temple, S.E. (2004) Visual pigment composition in zebrafish: Evidence for a rhodopsin-porphyropsin interchange system. Visual neuroscience. 21(6):945-952