ZFIN ID: ZDB-LAB-080129-1
Scholpp Lab
PI/Director: Scholpp, Steffen
Contact Person: Scholpp, Steffen
Email: s.scholpp@exeter.ac.uk
URL: http://biosciences.exeter.ac.uk/staff/index.php?web_id=Steffen_Scholpp
Address: Living System Institute University of Exeter Exeter, UK EX4 4QD
Country: United Kingdom
Phone:
Fax:
Line Designation: uex


GENOMIC FEATURES ORIGINATING FROM THIS LAB
Show all 2 genomic features


STATEMENT OF RESEARCH INTERESTS
Development of the diencephalon/thalamus

Function of the mid-diencephalic organizer 'ZLI'

Function of Lhx genes during thalamic regionalization

2D & 3D cell culture systems and Neuroenigneering


LAB MEMBERS
Brunt, Lucy Post-Doc Viana, Joana Post-Doc Mattes, Banjamin Graduate Student
Schindler, Simone Technical Staff


ZEBRAFISH PUBLICATIONS OF LAB MEMBERS
Brunt, L., Greicius, G., Rogers, S., Evans, B.D., Virshup, D.M., Wedgwood, K.C.A., Scholpp, S. (2021) Vangl2 promotes the formation of long cytonemes to enable distant Wnt/β-catenin signaling. Nature communications. 12:2058
Scholpp, S. (2020) Introduction: in vivo cell biology in zebrafish. Histochemistry and cell biology. 154(5):457-461
Dawes, M.L., Soeller, C., Scholpp, S. (2020) Studying molecular interactions in the intact organism: fluorescence correlation spectroscopy in the living zebrafish embryo. Histochemistry and cell biology. 154(5):507-519
Rosenbauer, J., Zhang, C., Mattes, B., Reinartz, I., Wedgwood, K., Schindler, S., Sinner, C., Scholpp, S., Schug, A. (2020) Modeling of Wnt-mediated tissue patterning in vertebrate embryogenesis. PLoS Computational Biology. 16:e1007417
Bosze, B., Ono, Y., Mattes, B., Sinner, C., Gourain, V., Thumberger, T., Tlili, S., Wittbrodt, J., Saunders, T.E., Strähle, U., Schug, A., Scholpp, S. (2020) Pcdh18a regulates endocytosis of E-cadherin during axial mesoderm development in zebrafish. Histochemistry and cell biology. 154(5):463-480
Viana, J., Wildman, N., Hannon, E., Farbos, A., Neill, P.O., Moore, K., van Aerle, R., Paull, G., Santos, E., Mill, J. (2020) Clozapine-induced transcriptional changes in the zebrafish brain. NPJ schizophrenia. 6:3
Giovannone, D., Paul, S., Schindler, S., Arata, C., Farmer, D.T., Patel, P., Smeeton, J., Crump, J.G. (2019) Programmed conversion of hypertrophic chondrocytes into osteoblasts and marrow adipocytes within zebrafish bones. eLIFE. 8:
Mattes, B., Dang, Y., Greicius, G., Kaufmann, L.T., Prunsche, B., Rosenbauer, J., Stegmaier, J., Mikut, R., Özbek, S., Nienhaus, G.U., Schug, A., Virshup, D.M., Scholpp, S. (2018) Wnt/PCP controls spreading of Wnt/β-catenin signals by cytonemes in vertebrates. eLIFE. 7:
Liu, T.L., Upadhyayula, S., Milkie, D.E., Singh, V., Wang, K., Swinburne, I.A., Mosaliganti, K.R., Collins, Z.M., Hiscock, T.W., Shea, J., Kohrman, A.Q., Medwig, T.N., Dambournet, D., Forster, R., Cunniff, B., Ruan, Y., Yashiro, H., Scholpp, S., Meyerowitz, E.M., Hockemeyer, D., Drubin, D.G., Martin, B.L., Matus, D.Q., Koyama, M., Megason, S.G., Kirchhausen, T., Betzig, E. (2018) Observing the cell in its native state: Imaging subcellular dynamics in multicellular organisms. Science (New York, N.Y.). 360(6386):
Laing, L.V., Viana, J., Dempster, E., Uren Webster, T.M., van Aerle, R., Mill, J., Santos, E.M. (2018) Sex-specific transcription and DNA methylation profiles of reproductive and epigenetic associated genes in the gonads and livers of breeding zebrafish. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. 222:16-25
Brunt, L., Scholpp, S. (2017) The function of endocytosis in Wnt signaling.. Cellular and molecular life sciences : CMLS. 75(5):785-795
Brunt, L.H., Begg, K., Kague, E., Cross, S., Hammond, C.L. (2017) Wnt signalling controls the response to mechanical loading during Zebrafish joint development. Development (Cambridge, England). 144(15):2798-2809
Brunt, L.H., Roddy, K.A., Rayfield, E.J., Hammond, C.L. (2016) Building Finite Element Models to Investigate Zebrafish Jaw Biomechanics. Journal of visualized experiments : JoVE. (118)
Brunt, L.H., Skinner, R.E., Roddy, K.A., Araujo, N.M., Rayfield, E.J., Hammond, C.L. (2016) Differential effects of altered patterns of movement and strain on joint cell behaviour and skeletal morphogenesis. Osteoarthritis and Cartilage. 24(11):1940-1950
Askary, A., Smeeton, J., Paul, S., Schindler, S., Braasch, I., Ellis, N.A., Postlethwait, J., Miller, C.T., Crump, J.G. (2016) Ancient origin of lubricated joints in bony vertebrates. eLIFE. 5
Brinkmann, E.M., Mattes, B., Kumar, R., Hagemann, A.I., Gradl, D., Scholpp, S., Steinbeisser, H., Kaufmann, L.T., Ozbek, S. (2016) Secreted frizzled-related protein 2 (sFRP2) redirects non-canonical Wnt signaling from Fz7 to Ror2 during vertebrate gastrulation. The Journal of biological chemistry. 291(26):13730-42
Paul, S., Schindler, S., Giovannone, D., de Millo Terrazzani, A., Mariani, F.V., Crump, J.G. (2016) Ihha induces hybrid cartilage-bone cells during zebrafish jawbone regeneration. Development (Cambridge, England). 143(12):2066-76
Stanganello, E., Scholpp, S. (2016) Role of cytonemes in Wnt transport.. Journal of Cell Science. 129(4):665-72
Brunt, L. (2016) The role of biomechanics and signalling in zebrafish joint morphogenesis. Ph.D. Thesis.
Brunt, L.H., Norton, J.L., Bright, J.A., Rayfield, E.J., Hammond, C.L. (2015) Finite element modelling predicts changes in joint shape and cell behaviour due to loss of muscle strain in jaw development. Journal of biomechanics. 48(12):3112-22
Hirschbiel, A.F., Geyer, S., Yameen, B., Welle, A., Nikolov, P., Giselbrecht, S., Scholpp, S., Delaittre, G., Barner-Kowollik, C. (2015) Photolithographic patterning of 3D-formed polycarbonate films for targeted cell guiding. Advanced materials (Deerfield Beach, Fla.). 27:2621-6
Takamiya, M., Weger, B.D., Schindler, S., Beil, T., Yang, L., Armant, O., Ferg, M., Schlunck, G., Reinhard, T., Dickmeis, T., Rastegar, S., Strähle, U. (2015) Molecular Description of Eye Defects in the Zebrafish Pax6b Mutant, sunrise, Reveals a Pax6b-Dependent Genetic Network in the Developing Anterior Chamber. PLoS One. 10:e0117645
Stanganello, E., Hagemann, A.I., Mattes, B., Sinner, C., Meyen, D., Weber, S., Schug, A., Raz, E., Scholpp, S. (2015) Filopodia-based Wnt transport during vertebrate tissue patterning. Nature communications. 6:5846
Hagemann, A.I., Kurz, J., Kauffeld, S., Chen, Q., Reeves, P.M., Weber, S., Schindler, S., Davidson, G., Kirchhausen, T., Scholpp, S. (2014) Correction: In vivo analysis of formation and endocytosis of the Wnt/²-Catenin signaling complex in zebrafish embryos. Journal of Cell Science. 127:5331
Hagemann, A.I., Kurz, J., Kauffeld, S., Chen, Q., Reeves, P.M., Weber, S., Schindler, S., Davidson, G., Kirchhausen, T., Scholpp, S. (2014) In vivo analysis of formation and endocytosis of the Wnt/β-Catenin signaling complex in zebrafish embryos. Journal of Cell Science. 127(Pt 18):3970-82
Chatterjee, M., Guo, Q., Weber, S., Scholpp, S., and Li, J.Y. (2014) Pax6 regulates the formation of the habenular nuclei by controlling the temporospatial expression of Shh in the diencephalon in vertebrates. BMC Biology. 12(1):13
Rengarajan, C., Matzke, A., Reiner, L., Orian-Rousseau, V., and Scholpp, S. (2014) Endocytosis of Fgf8 is a double-stage process and regulates spreading and signaling. PLoS One. 9(1):e86373
Scholpp, S., Poggi, L., and Zigman, M. (2013) Brain on the stage - spotlight on nervous system development in zebrafish: EMBO practical course, KIT, Sept. 2013. Neural Development. 8:23
Schmidt, R., Strähle, U., and Scholpp, S. (2013) Neurogenesis in zebrafish -- from embryo to adult. Neural Development. 8(1):3
Mitchell, R.E., Huitema, L.F., Skinner, R.H., Brunt, L.H., Severn, C., Schulte-Merker, S., and Hammond, C.L. (2013) New tools for studying osteoarthritis genetics in zebrafish. Osteoarthritis and Cartilage. 21(2):269-278
Heur, M., Jiao, S., Schindler, S., and Crump, J.G. (2013) Regenerative potential of the zebrafish corneal endothelium. Experimental Eye Research. 106:1-4
Mattes, B., Weber, S., Peres, J., Chen, Q., Davidson, G., Houart, C., and Scholpp, S. (2012) Wnt3 and Wnt3a are required for induction of the mid-diencephalic organizer in the caudal forebrain. Neural Development. 7(1):12
Peukert, D., Weber, S., Lumsden, A., and Scholpp, S. (2011) Lhx2 and lhx9 determine neuronal differentiation and compartition in the caudal forebrain by regulating wnt signaling. PLoS Biology. 9(12):e1001218
Fassier, C., Hutt, J.A., Scholpp, S., Lumsden, A., Giros, B., Nothias, F., Schneider-Maunoury, S., Houart, C., and Hazan, J. (2010) Zebrafish atlastin controls motility and spinal motor axon architecture via inhibition of the BMP pathway. Nature Neuroscience. 13(11):1380-1387
Scholpp, S., and Lumsden, A. (2010) Building a bridal chamber: development of the thalamus. Trends in neurosciences. 33(8):373-380
Gehrig, J., Reischl, M., Kalmar, E., Ferg, M., Hadzhiev, Y., Zaucker, A., Song, C., Schindler, S., Liebel, U., and Muller, F. (2009) Automated high-throughput mapping of promoter-enhancer interactions in zebrafish embryos. Nature Methods. 6(12):911-916
Scholpp, S., Delogu, A., Gilthorpe, J., Peukert, D., Schindler, S., and Lumsden, A. (2009) Her6 regulates the neurogenetic gradient and neuronal identity in the thalamus. Proceedings of the National Academy of Sciences of the United States of America. 106(47):19895-19900
Yu, S.R., Burkhardt, M., Nowak, M., Ries, J., Petrášek, Z., Scholpp, S., Schwille, P., and Brand, M. (2009) Fgf8 morphogen gradient forms by a source-sink mechanism with freely diffusing molecules. Nature. 461(7263):533-536
Scholpp, S., Foucher, I., Staudt, N., Peukert, D., Lumsden, A., and Houart, C. (2007) Otx1l, Otx2 and Irx1b establish and position the ZLI in the diencephalon. Development (Cambridge, England). 134(17):3167-3176
Wendl, T., Adzic, D., Schoenebeck, J.J., Scholpp, S., Brand, M., Yelon, D., and Rohr, K.B. (2007) Early developmental specification of the thyroid gland depends on han-expressing surrounding tissue and on FGF signals. Development (Cambridge, England). 134(15):2871-2879
Hadzhiev, Y., Lele, Z., Schindler, S., Wilson, S.W., Ahlberg, P., Straehle, U., and Mueller, F. (2007) Hedgehog signaling patterns the outgrowth of unpaired skeletal appendages in zebrafish. BMC Developmental Biology. 7(1):75
Erickson, T., Scholpp, S., Brand, M., Moens, C.B., and Waskiewicz, A. Jan (2007) Pbx proteins cooperate with Engrailed to pattern the midbrain-hindbrain and diencephalic-mesencephalic boundaries. Developmental Biology. 301(2):504-517
Scholpp, S., Wolf, O., Brand, M., and Lumsden, A. (2006) Hedgehog signalling from the zona limitans intrathalamica orchestrates patterning of the zebrafish diencephalon. Development (Cambridge, England). 133(5):855-864
Scholpp, S., and Brand, M. (2004) Endocytosis controls spreading and effective signaling range of fgf8 protein. Current biology : CB. 14(20):1834-1841
Scholpp, S., Groth, C., Lohs, C., Lardelli, M., and Brand, M. (2004) Zebrafish fgfr1 is a member of the fgf8 synexpression group and is required for fgf8 signalling at the midbrain-hindbrain boundary. Development genes and evolution. 214(6):285-295
Scholpp, S. and Brand, M. (2003) Integrity of the midbrain region is required to maintain the diencephalic-mesencephalic boundary in zebrafish no isthmus/pax2.1 mutants. Developmental dynamics : an official publication of the American Association of Anatomists. 228(3):313-322
Scholpp, S., Lohs, C., and Brand, M. (2003) Engrailed and Fgf8 act synergistically to maintain the boundary between diencephalon and mesencephalon. Development (Cambridge, England). 130(20):4881-4893
Scholpp, S. (2003) Genetic and cell biological mechanisms maintaining the forebrain-midbrain territory in zebrafish. Ph.D. Thesis. :141p
Picker, A., Scholpp, S., Bohli, H., Takeda, H., and Brand, M. (2002) A novel positive transcriptional feedback loop in midbrain-hindbrain boundary development is revealed through analysis of the zebrafish pax2.1 promoter in transgenic lines. Development (Cambridge, England). 129(13):3227-3239
Scholpp, S. and Brand, M. (2001) Morpholino-induced knockdown of zebrafish engrailed genes eng2 and eng3 reveals redundant and unique functions in midbrain–hindbrain boundary development. Genesis (New York, N.Y. : 2000). 30(3):129-133