ZFIN Person: Scholpp, Steffen

ZFIN ID: ZDB-PERS-990226-24

ZFIN ID: ZDB-PERS-990226-24

Scholpp, Steffen

Email:	s.scholpp@exeter.ac.uk
URL:	https://www.exeter.ac.uk/livingsystems/team/faculty/scholpp/
Affiliation:	Scholpp Lab
Address:	Associate Professor of Cell and Developmental Biology Living System Institute Biosciences, College of Life and Environmental Science University of Exeter Exeter, UK EX4 4QD
Country:	United Kingdom
Phone:
Fax:
ORCID ID:

BIOGRAPHY AND RESEARCH INTERESTS

1. Characterisation of the zona limitans intrathalamica (zli) in development of the forebrain.

2. Transport mechanism of signalling factors.

3. Advanced 2D & 3D cell culture systems and Neuroenigneering.

PUBLICATIONS

Zhang, C., Brunt, L., Ono, Y., Rogers, S., Scholpp, S. (2023) Cytoneme-mediated transport of active Wnt5b-Ror2 complexes in zebrafish. Nature. 625(7993):126-133

Rogers, S., Zhang, C., Anagnostidis, V., Liddle, C., Fishel, M.L., Gielen, F., Scholpp, S. (2023) Cancer-associated fibroblasts influence Wnt/PCP signaling in gastric cancer cells by cytoneme-based dissemination of ROR2. Proceedings of the National Academy of Sciences of the United States of America. 120:e2217612120e2217612120

Routledge, D., Rogers, S., Ono, Y., Brunt, L., Meniel, V., Tornillo, G., Ashktorab, H., Phesse, T., Scholpp, S. (2022) The scaffolding protein Flot2 promotes cytoneme-based transport of Wnt3 in gastric cancer. eLIFE. 11:

Winter, M.J., Ono, Y., Ball, J.S., Walentinsson, A., Michaelsson, E., Tochwin, A., Scholpp, S., Tyler, C.R., Rees, S., Hetheridge, M.J., Bohlooly-Y, M. (2022) A Combined Human in Silico and CRISPR/Cas9-Mediated in Vivo Zebrafish Based Approach to Provide Phenotypic Data for Supporting Early Target Validation. Frontiers in pharmacology. 13:827686

Brunt, L., Greicius, G., Rogers, S., Evans, B.D., Virshup, D.M., Wedgwood, K.C.A., Scholpp, S. (2021) Vangl2 promotes the formation of long cytonemes to enable distant Wnt/β-catenin signaling. Nature communications. 12:2058

Scholpp, S. (2020) Introduction: in vivo cell biology in zebrafish. Histochemistry and cell biology. 154(5):457-461

Dawes, M.L., Soeller, C., Scholpp, S. (2020) Studying molecular interactions in the intact organism: fluorescence correlation spectroscopy in the living zebrafish embryo. Histochemistry and cell biology. 154(5):507-519

Rosenbauer, J., Zhang, C., Mattes, B., Reinartz, I., Wedgwood, K., Schindler, S., Sinner, C., Scholpp, S., Schug, A. (2020) Modeling of Wnt-mediated tissue patterning in vertebrate embryogenesis. PLoS Computational Biology. 16:e1007417

Bosze, B., Ono, Y., Mattes, B., Sinner, C., Gourain, V., Thumberger, T., Tlili, S., Wittbrodt, J., Saunders, T.E., Strähle, U., Schug, A., Scholpp, S. (2020) Pcdh18a regulates endocytosis of E-cadherin during axial mesoderm development in zebrafish. Histochemistry and cell biology. 154(5):463-480

Mattes, B., Dang, Y., Greicius, G., Kaufmann, L.T., Prunsche, B., Rosenbauer, J., Stegmaier, J., Mikut, R., Özbek, S., Nienhaus, G.U., Schug, A., Virshup, D.M., Scholpp, S. (2018) Wnt/PCP controls spreading of Wnt/β-catenin signals by cytonemes in vertebrates. eLIFE. 7:

Liu, T.L., Upadhyayula, S., Milkie, D.E., Singh, V., Wang, K., Swinburne, I.A., Mosaliganti, K.R., Collins, Z.M., Hiscock, T.W., Shea, J., Kohrman, A.Q., Medwig, T.N., Dambournet, D., Forster, R., Cunniff, B., Ruan, Y., Yashiro, H., Scholpp, S., Meyerowitz, E.M., Hockemeyer, D., Drubin, D.G., Martin, B.L., Matus, D.Q., Koyama, M., Megason, S.G., Kirchhausen, T., Betzig, E. (2018) Observing the cell in its native state: Imaging subcellular dynamics in multicellular organisms. Science (New York, N.Y.). 360(6386):

Brunt, L., Scholpp, S. (2017) The function of endocytosis in Wnt signaling.. Cellular and molecular life sciences : CMLS. 75(5):785-795

Brinkmann, E.M., Mattes, B., Kumar, R., Hagemann, A.I., Gradl, D., Scholpp, S., Steinbeisser, H., Kaufmann, L.T., Ozbek, S. (2016) Secreted frizzled-related protein 2 (sFRP2) redirects non-canonical Wnt signaling from Fz7 to Ror2 during vertebrate gastrulation. The Journal of biological chemistry. 291(26):13730-42

Stanganello, E., Scholpp, S. (2016) Role of cytonemes in Wnt transport.. Journal of Cell Science. 129(4):665-72

Hirschbiel, A.F., Geyer, S., Yameen, B., Welle, A., Nikolov, P., Giselbrecht, S., Scholpp, S., Delaittre, G., Barner-Kowollik, C. (2015) Photolithographic patterning of 3D-formed polycarbonate films for targeted cell guiding. Advanced materials (Deerfield Beach, Fla.). 27:2621-6

Stanganello, E., Hagemann, A.I., Mattes, B., Sinner, C., Meyen, D., Weber, S., Schug, A., Raz, E., Scholpp, S. (2015) Filopodia-based Wnt transport during vertebrate tissue patterning. Nature communications. 6:5846

Hagemann, A.I., Kurz, J., Kauffeld, S., Chen, Q., Reeves, P.M., Weber, S., Schindler, S., Davidson, G., Kirchhausen, T., Scholpp, S. (2014) Correction: In vivo analysis of formation and endocytosis of the Wnt/²-Catenin signaling complex in zebrafish embryos. Journal of Cell Science. 127:5331

Hagemann, A.I., Kurz, J., Kauffeld, S., Chen, Q., Reeves, P.M., Weber, S., Schindler, S., Davidson, G., Kirchhausen, T., Scholpp, S. (2014) In vivo analysis of formation and endocytosis of the Wnt/β-Catenin signaling complex in zebrafish embryos. Journal of Cell Science. 127(Pt 18):3970-82

Chatterjee, M., Guo, Q., Weber, S., Scholpp, S., and Li, J.Y. (2014) Pax6 regulates the formation of the habenular nuclei by controlling the temporospatial expression of Shh in the diencephalon in vertebrates. BMC Biology. 12(1):13

Rengarajan, C., Matzke, A., Reiner, L., Orian-Rousseau, V., and Scholpp, S. (2014) Endocytosis of Fgf8 is a double-stage process and regulates spreading and signaling. PLoS One. 9(1):e86373

Scholpp, S., Poggi, L., and Zigman, M. (2013) Brain on the stage - spotlight on nervous system development in zebrafish: EMBO practical course, KIT, Sept. 2013. Neural Development. 8:23

Schmidt, R., Strähle, U., and Scholpp, S. (2013) Neurogenesis in zebrafish -- from embryo to adult. Neural Development. 8(1):3

Mattes, B., Weber, S., Peres, J., Chen, Q., Davidson, G., Houart, C., and Scholpp, S. (2012) Wnt3 and Wnt3a are required for induction of the mid-diencephalic organizer in the caudal forebrain. Neural Development. 7(1):12

Peukert, D., Weber, S., Lumsden, A., and Scholpp, S. (2011) Lhx2 and lhx9 determine neuronal differentiation and compartition in the caudal forebrain by regulating wnt signaling. PLoS Biology. 9(12):e1001218

Fassier, C., Hutt, J.A., Scholpp, S., Lumsden, A., Giros, B., Nothias, F., Schneider-Maunoury, S., Houart, C., and Hazan, J. (2010) Zebrafish atlastin controls motility and spinal motor axon architecture via inhibition of the BMP pathway. Nature Neuroscience. 13(11):1380-1387

Scholpp, S., and Lumsden, A. (2010) Building a bridal chamber: development of the thalamus. Trends in neurosciences. 33(8):373-380

Scholpp, S., Delogu, A., Gilthorpe, J., Peukert, D., Schindler, S., and Lumsden, A. (2009) Her6 regulates the neurogenetic gradient and neuronal identity in the thalamus. Proceedings of the National Academy of Sciences of the United States of America. 106(47):19895-19900

Yu, S.R., Burkhardt, M., Nowak, M., Ries, J., Petrášek, Z., Scholpp, S., Schwille, P., and Brand, M. (2009) Fgf8 morphogen gradient forms by a source-sink mechanism with freely diffusing molecules. Nature. 461(7263):533-536

Scholpp, S., Foucher, I., Staudt, N., Peukert, D., Lumsden, A., and Houart, C. (2007) Otx1l, Otx2 and Irx1b establish and position the ZLI in the diencephalon. Development (Cambridge, England). 134(17):3167-3176

Wendl, T., Adzic, D., Schoenebeck, J.J., Scholpp, S., Brand, M., Yelon, D., and Rohr, K.B. (2007) Early developmental specification of the thyroid gland depends on han-expressing surrounding tissue and on FGF signals. Development (Cambridge, England). 134(15):2871-2879

Erickson, T., Scholpp, S., Brand, M., Moens, C.B., and Waskiewicz, A. Jan (2007) Pbx proteins cooperate with Engrailed to pattern the midbrain-hindbrain and diencephalic-mesencephalic boundaries. Developmental Biology. 301(2):504-517

Scholpp, S., Wolf, O., Brand, M., and Lumsden, A. (2006) Hedgehog signalling from the zona limitans intrathalamica orchestrates patterning of the zebrafish diencephalon. Development (Cambridge, England). 133(5):855-864

Scholpp, S., and Brand, M. (2004) Endocytosis controls spreading and effective signaling range of fgf8 protein. Current biology : CB. 14(20):1834-1841

Scholpp, S., Groth, C., Lohs, C., Lardelli, M., and Brand, M. (2004) Zebrafish fgfr1 is a member of the fgf8 synexpression group and is required for fgf8 signalling at the midbrain-hindbrain boundary. Development genes and evolution. 214(6):285-295

Scholpp, S. and Brand, M. (2003) Integrity of the midbrain region is required to maintain the diencephalic-mesencephalic boundary in zebrafish no isthmus/pax2.1 mutants. Developmental Dynamics : an official publication of the American Association of Anatomists. 228(3):313-322

Scholpp, S., Lohs, C., and Brand, M. (2003) Engrailed and Fgf8 act synergistically to maintain the boundary between diencephalon and mesencephalon. Development (Cambridge, England). 130(20):4881-4893

Scholpp, S. (2003) Genetic and cell biological mechanisms maintaining the forebrain-midbrain territory in zebrafish. Ph.D. Thesis. :141p

Picker, A., Scholpp, S., Bohli, H., Takeda, H., and Brand, M. (2002) A novel positive transcriptional feedback loop in midbrain-hindbrain boundary development is revealed through analysis of the zebrafish pax2.1 promoter in transgenic lines. Development (Cambridge, England). 129(13):3227-3239

Scholpp, S. and Brand, M. (2001) Morpholino-induced knockdown of zebrafish engrailed genes eng2 and eng3 reveals redundant and unique functions in midbrain–hindbrain boundary development. Genesis (New York, N.Y. : 2000). 30(3):129-133

NON-ZEBRAFISH PUBLICATIONS
Scholpp, S. and Kloas, W. (1998) Retinol-binding protein (RBP)-mRNA to studying endocrine disruptors. Endicrinology and Diabetes 106, Suppl. 1.