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Publication: Perone et al., 2026 - Aip mutation leads to significant alterations in gene expression, altered sensitivity to Ahr ligands, and early lethality in zebrafish
All Figures: Figures for Perone et al., 2026

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FIGURE 1

Morphological endpoints with significantly increased incidence in five dpf aip^wh239 larvae following exposure to Ahr ligands near their EC₅₀ concentrations (A) 0.2 µM PCB126 (B) 11 µM 5-NAN (C) 40 μM BkF, and (D) 0.75 µM leflunomide. Affected endpoints are displayed on the x-axis, while the percent incidence of the endpoint is displayed on the y-axis. Significant differences between each genotype are denoted by an asterisk, * (p-value ≤0.05, Kruskal–Wallis test followed by Dunn’s post hoc tests with Holm correction, error bars = standard error). Each experiment demonstrated that aip^wh239−/− larvae had differential susceptibility to Ahr ligands, with reduced sensitivity to all exposures except leflunomide, for which sensitivity was greater.

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