IMAGE

Fig. 1

ID

ZDB-IMAGE-250315-49

Genes

Antibodies

Ab4-tbk1

Publication

Raas et al., 2025 - TBK1 is involved in programmed cell death and ALS-related pathways in novel zebrafish models

All Figures

Figures for Raas et al., 2025

Image

Figure Caption

Fig. 1 Motor behavior and motor neuron phenotype induced by tbk1 knockdown in zebrafish larvae.

A Western blot quantification (ratio to β-actin level) of tbk1 expression after antisense morpholino oligonucleotide (AMO)- and hTBK1 mRNA injections. B Traces representative of the touch-evoked escape response (TEER) in 48 hpf zebrafish injected with tbk1 or mismatch AMO and hTBK1 mRNA injections. C Quantitative analysis of the TEER velocity of 48 hpf zebrafish larvae injected with tbk1 or mismatch AMO and rescued with mRNA encoding human TBK1. One-way ANOVA with Tukey’s multiple comparisons test was used. *p < 0.05, **p < 0.01). D In vivo quantification of spinal motor neuron axonal length and number in 48 hpf transgenic Tg(mnx1:gal4/UAS:RFP) embryos injected with tbk1 or mismatch AMO.

Figure Data

Expression / Labeling details

Phenotype details

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Cell Death Discov