Fig. 2

Fig. 2

Significant enrichment of brain-preference genes in head transcriptome compared to that in the whole embryo RNA-seq. A Overview of identification of developmental brain-preference genes by integrating datasets from this study and other publication. B Number of stage-specific expression genes. C The upset plots of up- and down-regulated DEGs between head and whole embryo developmental RNA-seq. D Significant enrichment of brain-preference and synaptosome genes in DEGs only detected from head transcriptome. E High correlation of DEGs detected both in head and whole embryo transcriptome based on log2-transformed fold-change. F Disease enrichment of developmental brain-preference genes. G RT-qPCR validation of genes with preferred expression in brain. H In situ hybridization of protein-coding genes, aldocb and dpysl5b