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Fig. 1 Twenty-Four Rare (ExAC NFE MAF <0.001) TP73 Nonsynonymous Variants Were Found Across Multiple Cohorts (A) TA-p73 and ΔN-p73, which have opposing tumor suppressive/oncogenic functions, are expressed from 2 separate promoters. Alternative splicing events also give rise to a multitude of different isoforms (such as ΔN-p73α and ΔN-p73γ). (B) Primary structure of TA-p73α and ΔN-p73α. Number within the circles refers to the variant number in table 1. ExAC = Exome Aggregation Consortium; MAF = minor allele frequency; NFE = non-Finnish European.
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