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Fig. 5
Predicted Protein Structures from different programs These images show (A) the AlphaFold2 structure prediction of IRF6 (residues 1–467), (B) the SWISS-MODEL structure prediction of the transactivation domain of IRF6 (residues 214–445), and (C) the I-TASSER structure prediction of IRF6 (residues 1–467) of highest confidence. Green residues were benign and red residues were pathogenic according to functional analysis. (D) The two SWISS-MODEL structures of the IRF6 transactivation and DNA-binding domains (residues 9–122) were superimposed onto the AlphaFold2 predicted structure.
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