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Fig. 8 Effects of cell compression on AP and resting potential in current-clamped adult zebrafish skeletal muscle fibers. (A) Changes of AP induced by cell compression. The two first and the two last AP in a 0.5-s 50-Hz train of AP are presented before and during cell compression in the same fiber after re-establishing the resting potential at −100 mV during cell compression. (B) Depolarization of the resting membrane potential and reduction in the voltage change induced by a 50-ms current step of −2 nA before and during cell compression in the same fiber before re-establishing the resting potential at −100 mV during cell compression (Left). Histogram showing mean voltage change induced by the negative current step (Left axis) and mean resting membrane potential (Right axis) before and during cell compression in six fibers (Right). (C) Superimposition of the first AP of the train shown in A before and during cell compression on an expanded scale (Left). Histogram showing mean change in AP amplitude and mean elapsed time between AP peak and 50% or 75% repolarization induced by cell compression in the same fibers (n = 6) (Right).