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Fig. 5 Loss of tek in the Acanthomorphata lineage. (A) Phylogenetic profile of TEK and TIE1 in deuterostomes on the order level. Colour code indicates the feature architecture similarity (FAS) score of the orthologues to the human seed protein. Dot size indicates the fraction of species subsumed in an order that carries an orthologue to the respective protein. (B) Phylogeny of TEK and TIE1. The coloured ring segments represent the three main vertebrate groups. TEK/TIE1 represents the primordial protein outside the vertebrates; TEK and TIE1 are each indicated by coloured taxa. The Acanthomorphata and their sister clade, the Salmoniformes, are indicated by orange and green branches, respectively. Branch labels reflect the percent bootstrap support, where the dot size is proportional to the support value. Only branches with a minimum bootstrap support of 50 are labelled. The tree is provided in Newick format in File S1 in the supplementary information, and the protein IDs of the TEK and TIE1 orthologues together with the protein sequences are provided in File S2 in the supplementary information.