ZFIN Image: Zou et al., 2023, Fig. 7

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Figure Caption

Fig. 7 Negative feedback loop between canonical/non-canonical Wnts and Tlr4/NFκB determines the precise size of zebrafish dorsal organizer.

Model of the role of Tlr/NFκB signaling in the initiation of embryonic DV axis formation. In Drosophila, Wnt-mediated negative feedback regulation of Toll/NFκB signaling determines the embryonic DV pattern. In zebrafish, negative feedback regulation between canonical Wnt (caWnt), non-canonical Wnt (Wnt5b), and Tlr4/NFκB generates the precise size of the dorsal organizer and the consequent DV pattern.

Acknowledgments

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